Five Unreported Ketone Compounds—Penicrustones A–E—From the Endophytic Fungus <i>Penicillium crustosum</i>
Five unreported ketone compounds—penicrustones A–E—were isolated from the solid fermentation of the endophytic fungus <i>Penicillium crustosum</i>. Their structures were elucidated on the basis of extensive spectroscopic analysis. Their absolute configurations were determined via ECD cal...
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2024-10-01
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| author | Dongmei Lin Lian Yang Jin Yang Feixing Li Xiuming Cui Xiaoyan Yang |
| author_facet | Dongmei Lin Lian Yang Jin Yang Feixing Li Xiuming Cui Xiaoyan Yang |
| author_sort | Dongmei Lin |
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| description | Five unreported ketone compounds—penicrustones A–E—were isolated from the solid fermentation of the endophytic fungus <i>Penicillium crustosum</i>. Their structures were elucidated on the basis of extensive spectroscopic analysis. Their absolute configurations were determined via ECD calculations and single-crystal X-Ray crystallography. All compounds were evaluated for their antimicrobial and antitumor activities. Compounds <b>4</b> and <b>5</b> showed moderate inhibitory effects on <i>Micrococcus luteus</i>, with MIC values of 12.5 and 25.0 μg/mL, respectively. In addition to this, compound 4 also showed cytotoxicity on tumor cell lines KTC-1 and Hela, with IC<sub>50</sub> values of 4.28 and 4.64 μg/mL, respectively. |
| format | Article |
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| institution | OA Journals |
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| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
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| series | Microorganisms |
| spelling | doaj-art-c7e1be5405044a40a3daf285cd8319b32025-08-20T02:04:59ZengMDPI AGMicroorganisms2076-26072024-10-011211219510.3390/microorganisms12112195Five Unreported Ketone Compounds—Penicrustones A–E—From the Endophytic Fungus <i>Penicillium crustosum</i>Dongmei Lin0Lian Yang1Jin Yang2Feixing Li3Xiuming Cui4Xiaoyan Yang5Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaFive unreported ketone compounds—penicrustones A–E—were isolated from the solid fermentation of the endophytic fungus <i>Penicillium crustosum</i>. Their structures were elucidated on the basis of extensive spectroscopic analysis. Their absolute configurations were determined via ECD calculations and single-crystal X-Ray crystallography. All compounds were evaluated for their antimicrobial and antitumor activities. Compounds <b>4</b> and <b>5</b> showed moderate inhibitory effects on <i>Micrococcus luteus</i>, with MIC values of 12.5 and 25.0 μg/mL, respectively. In addition to this, compound 4 also showed cytotoxicity on tumor cell lines KTC-1 and Hela, with IC<sub>50</sub> values of 4.28 and 4.64 μg/mL, respectively.https://www.mdpi.com/2076-2607/12/11/2195<i>Penicillium crustosum</i>funguspenicrustoneactivityX-Ray diffraction |
| spellingShingle | Dongmei Lin Lian Yang Jin Yang Feixing Li Xiuming Cui Xiaoyan Yang Five Unreported Ketone Compounds—Penicrustones A–E—From the Endophytic Fungus <i>Penicillium crustosum</i> Microorganisms <i>Penicillium crustosum</i> fungus penicrustone activity X-Ray diffraction |
| title | Five Unreported Ketone Compounds—Penicrustones A–E—From the Endophytic Fungus <i>Penicillium crustosum</i> |
| title_full | Five Unreported Ketone Compounds—Penicrustones A–E—From the Endophytic Fungus <i>Penicillium crustosum</i> |
| title_fullStr | Five Unreported Ketone Compounds—Penicrustones A–E—From the Endophytic Fungus <i>Penicillium crustosum</i> |
| title_full_unstemmed | Five Unreported Ketone Compounds—Penicrustones A–E—From the Endophytic Fungus <i>Penicillium crustosum</i> |
| title_short | Five Unreported Ketone Compounds—Penicrustones A–E—From the Endophytic Fungus <i>Penicillium crustosum</i> |
| title_sort | five unreported ketone compounds penicrustones a e from the endophytic fungus i penicillium crustosum i |
| topic | <i>Penicillium crustosum</i> fungus penicrustone activity X-Ray diffraction |
| url | https://www.mdpi.com/2076-2607/12/11/2195 |
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