Prevalence and association of non-alcoholic fatty liver disease and insulin resistance among non-diabetic obese, overweight, and metabolically obese normal-weight adult patients attending at a tertiary care hospital in Eastern India
Background: Worldwide, the incidence of obesity, overweight, and metabolic syndrome is dramatically increasing. Non-alcoholic fatty liver disease (NAFLD) is associated with both obesity/overweight and metabolic syndrome. Aims and Objectives: The aim of this study is to assess non-invasively the p...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Manipal College of Medical Sciences, Pokhara
2025-02-01
|
| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://ajmsjournal.info/index.php/AJMS/article/view/4341 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832575431877853184 |
|---|---|
| author | Samik Pramanik Jimmy Barua Lokanathan V Sharmistha Roy |
| author_facet | Samik Pramanik Jimmy Barua Lokanathan V Sharmistha Roy |
| author_sort | Samik Pramanik |
| collection | DOAJ |
| description | Background: Worldwide, the incidence of obesity, overweight, and metabolic syndrome is dramatically increasing. Non-alcoholic fatty liver disease (NAFLD) is associated with both obesity/overweight and metabolic syndrome.
Aims and Objectives: The aim of this study is to assess non-invasively the prevalence and association of NAFLD and insulin resistance among non-diabetic obese, overweight, and metabolically obese normal-weight (MONW) adults.
Materials and Methods: This single-center cross-sectional study included 137 subjects aged more than 18 years, out of which 50 were obese, 22 were overweight, and 31 MONW. All subjects underwent detailed history, complete physical examination, laboratory test, and grading of hepatic fat by ultrasonography.
Results: The mean age (mean± standard deviation) of the patients was 36.91±11.01 years with a range of 18–67 years. 53 (38.7%) and 84 (61.3%) of the patients were male and female, respectively. Out of the 137 patients, 73 (53.3%) of patients had NAFLD. The prevalence of NAFLD was significantly higher in the obese group (56.2%) as compared to others (Z=5.56; P<0.0001). The prevalence of NAFLD among overweight, MONW, and normal body mass index (BMI) were 17.8%, 19.2%, and 6.8%, respectively. The proportion of Grade-1 and Grade-2 NAFLD was significantly higher than that of Grade-3 (Z=4.16; P<0.0001). There was a significant association between BMI, insulin resistance measured by homeostasis model assessment-estimated insulin resistance (HOMA-IR), and grade of fatty liver of the patients (P<0.0001).
Conclusion: NAFLD is more prevalent in obese than other groups. The grade of fatty liver has a significant association with HOMA-IR and BMI. |
| format | Article |
| id | doaj-art-c7dafe609aca48858a39f030805b57db |
| institution | Kabale University |
| issn | 2467-9100 2091-0576 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj-art-c7dafe609aca48858a39f030805b57db2025-02-01T08:33:11ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762025-02-011625256https://doi.org/10.71152/ajms.v16i2.4341Prevalence and association of non-alcoholic fatty liver disease and insulin resistance among non-diabetic obese, overweight, and metabolically obese normal-weight adult patients attending at a tertiary care hospital in Eastern IndiaSamik Pramanik 0https://orcid.org/0000-0002-1545-8597Jimmy Barua1https://orcid.org/0009-0007-5912-4656Lokanathan V 2https://orcid.org/0009-0009-5632-7049Sharmistha Roy 3https://orcid.org/0009-0004-4328-5269Assistant Professor, Department of General Medicine, Deben Mahata Government Medical College, Purulia, West Bengal, India Assistant Professor, Department of Respiratory Medicine, Deben Mahata Government Medical College, Purulia, West Bengal, India Assistant Professor, Department of Biochemistry, Deben Mahata Government Medical College, Purulia, West Bengal, India Senior Resident, Department of Radiation Oncology, Medical College, Kolkata, West Bengal, India Background: Worldwide, the incidence of obesity, overweight, and metabolic syndrome is dramatically increasing. Non-alcoholic fatty liver disease (NAFLD) is associated with both obesity/overweight and metabolic syndrome. Aims and Objectives: The aim of this study is to assess non-invasively the prevalence and association of NAFLD and insulin resistance among non-diabetic obese, overweight, and metabolically obese normal-weight (MONW) adults. Materials and Methods: This single-center cross-sectional study included 137 subjects aged more than 18 years, out of which 50 were obese, 22 were overweight, and 31 MONW. All subjects underwent detailed history, complete physical examination, laboratory test, and grading of hepatic fat by ultrasonography. Results: The mean age (mean± standard deviation) of the patients was 36.91±11.01 years with a range of 18–67 years. 53 (38.7%) and 84 (61.3%) of the patients were male and female, respectively. Out of the 137 patients, 73 (53.3%) of patients had NAFLD. The prevalence of NAFLD was significantly higher in the obese group (56.2%) as compared to others (Z=5.56; P<0.0001). The prevalence of NAFLD among overweight, MONW, and normal body mass index (BMI) were 17.8%, 19.2%, and 6.8%, respectively. The proportion of Grade-1 and Grade-2 NAFLD was significantly higher than that of Grade-3 (Z=4.16; P<0.0001). There was a significant association between BMI, insulin resistance measured by homeostasis model assessment-estimated insulin resistance (HOMA-IR), and grade of fatty liver of the patients (P<0.0001). Conclusion: NAFLD is more prevalent in obese than other groups. The grade of fatty liver has a significant association with HOMA-IR and BMI.https://ajmsjournal.info/index.php/AJMS/article/view/4341non-alcoholic fatty liver disease; insulin resistance; obese; overweight; metabolically obese normal weight |
| spellingShingle | Samik Pramanik Jimmy Barua Lokanathan V Sharmistha Roy Prevalence and association of non-alcoholic fatty liver disease and insulin resistance among non-diabetic obese, overweight, and metabolically obese normal-weight adult patients attending at a tertiary care hospital in Eastern India Asian Journal of Medical Sciences non-alcoholic fatty liver disease; insulin resistance; obese; overweight; metabolically obese normal weight |
| title | Prevalence and association of non-alcoholic fatty liver disease and insulin resistance among non-diabetic obese, overweight, and metabolically obese normal-weight adult patients attending at a tertiary care hospital in Eastern India |
| title_full | Prevalence and association of non-alcoholic fatty liver disease and insulin resistance among non-diabetic obese, overweight, and metabolically obese normal-weight adult patients attending at a tertiary care hospital in Eastern India |
| title_fullStr | Prevalence and association of non-alcoholic fatty liver disease and insulin resistance among non-diabetic obese, overweight, and metabolically obese normal-weight adult patients attending at a tertiary care hospital in Eastern India |
| title_full_unstemmed | Prevalence and association of non-alcoholic fatty liver disease and insulin resistance among non-diabetic obese, overweight, and metabolically obese normal-weight adult patients attending at a tertiary care hospital in Eastern India |
| title_short | Prevalence and association of non-alcoholic fatty liver disease and insulin resistance among non-diabetic obese, overweight, and metabolically obese normal-weight adult patients attending at a tertiary care hospital in Eastern India |
| title_sort | prevalence and association of non alcoholic fatty liver disease and insulin resistance among non diabetic obese overweight and metabolically obese normal weight adult patients attending at a tertiary care hospital in eastern india |
| topic | non-alcoholic fatty liver disease; insulin resistance; obese; overweight; metabolically obese normal weight |
| url | https://ajmsjournal.info/index.php/AJMS/article/view/4341 |
| work_keys_str_mv | AT samikpramanik prevalenceandassociationofnonalcoholicfattyliverdiseaseandinsulinresistanceamongnondiabeticobeseoverweightandmetabolicallyobesenormalweightadultpatientsattendingatatertiarycarehospitalineasternindia AT jimmybarua prevalenceandassociationofnonalcoholicfattyliverdiseaseandinsulinresistanceamongnondiabeticobeseoverweightandmetabolicallyobesenormalweightadultpatientsattendingatatertiarycarehospitalineasternindia AT lokanathanv prevalenceandassociationofnonalcoholicfattyliverdiseaseandinsulinresistanceamongnondiabeticobeseoverweightandmetabolicallyobesenormalweightadultpatientsattendingatatertiarycarehospitalineasternindia AT sharmistharoy prevalenceandassociationofnonalcoholicfattyliverdiseaseandinsulinresistanceamongnondiabeticobeseoverweightandmetabolicallyobesenormalweightadultpatientsattendingatatertiarycarehospitalineasternindia |