Cutaneous involvement of light chain deposition disease: A case report
Light chain deposition disease is a rare condition associated with plasma cell dyscrasia and other lymphoproliferative disorders in which there is overproduction and deposition of non-amyloid light chains in various organs, leading to organ dysfunction. It is well-established that the majority of pa...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-12-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X241307116 |
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| author | Saba Vafaei-Nodeh Hamid Masoudi |
| author_facet | Saba Vafaei-Nodeh Hamid Masoudi |
| author_sort | Saba Vafaei-Nodeh |
| collection | DOAJ |
| description | Light chain deposition disease is a rare condition associated with plasma cell dyscrasia and other lymphoproliferative disorders in which there is overproduction and deposition of non-amyloid light chains in various organs, leading to organ dysfunction. It is well-established that the majority of patients with light chain deposition disease exhibit renal involvement. Although awareness of extrarenal manifestations is increasing, cutaneous involvement has rarely been reported. Herein, we present a case of light chain deposition disease with cutaneous manifestations in the absence of any renal disease. A biopsy of the skin revealed amorphous eosinophilic material within the superficial dermis. Using special stains, immunohistochemistry, and direct immunofluorescence, the deposits were confirmed to be kappa light chains. |
| format | Article |
| id | doaj-art-c7d96a3aa38e428383ce051eecda9561 |
| institution | OA Journals |
| issn | 2050-313X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj-art-c7d96a3aa38e428383ce051eecda95612025-08-20T01:58:30ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2024-12-011210.1177/2050313X241307116Cutaneous involvement of light chain deposition disease: A case reportSaba Vafaei-Nodeh0Hamid Masoudi1Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, CanadaSt. Paul’s Hospital, Vancouver, BC, CanadaLight chain deposition disease is a rare condition associated with plasma cell dyscrasia and other lymphoproliferative disorders in which there is overproduction and deposition of non-amyloid light chains in various organs, leading to organ dysfunction. It is well-established that the majority of patients with light chain deposition disease exhibit renal involvement. Although awareness of extrarenal manifestations is increasing, cutaneous involvement has rarely been reported. Herein, we present a case of light chain deposition disease with cutaneous manifestations in the absence of any renal disease. A biopsy of the skin revealed amorphous eosinophilic material within the superficial dermis. Using special stains, immunohistochemistry, and direct immunofluorescence, the deposits were confirmed to be kappa light chains.https://doi.org/10.1177/2050313X241307116 |
| spellingShingle | Saba Vafaei-Nodeh Hamid Masoudi Cutaneous involvement of light chain deposition disease: A case report SAGE Open Medical Case Reports |
| title | Cutaneous involvement of light chain deposition disease: A case report |
| title_full | Cutaneous involvement of light chain deposition disease: A case report |
| title_fullStr | Cutaneous involvement of light chain deposition disease: A case report |
| title_full_unstemmed | Cutaneous involvement of light chain deposition disease: A case report |
| title_short | Cutaneous involvement of light chain deposition disease: A case report |
| title_sort | cutaneous involvement of light chain deposition disease a case report |
| url | https://doi.org/10.1177/2050313X241307116 |
| work_keys_str_mv | AT sabavafaeinodeh cutaneousinvolvementoflightchaindepositiondiseaseacasereport AT hamidmasoudi cutaneousinvolvementoflightchaindepositiondiseaseacasereport |