A rare case of acute liver failure due to disseminated Varicella-Zoster Virus (VZV) infection
Varicella zoster virus (VZV) is a human alpha herpes virus that typically manifests in humans with two distinct cutaneous phenotypes: primary varicella, or chickenpox, and secondary reactivation, or Shingles, after establishing latency in the cranial and dorsal root ganglia. VZV infection can presen...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | IDCases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250925000794 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850136279783571456 |
|---|---|
| author | Harris T. Feldman Matthew Neale Ajay Batra Mark Mangano Michael C. Newstein |
| author_facet | Harris T. Feldman Matthew Neale Ajay Batra Mark Mangano Michael C. Newstein |
| author_sort | Harris T. Feldman |
| collection | DOAJ |
| description | Varicella zoster virus (VZV) is a human alpha herpes virus that typically manifests in humans with two distinct cutaneous phenotypes: primary varicella, or chickenpox, and secondary reactivation, or Shingles, after establishing latency in the cranial and dorsal root ganglia. VZV infection can present with rarer manifestations including encephalitis, pneumonia, hepatitis, myocarditis, and nephritis. Immunocompromised populations are at the greatest risk for cutaneous and visceral dissemination. The progression of VZV hepatitis to acute liver failure is exceedingly rare, with very few published cases in the literature. In the following case, we report the initial presentation and clinical manifestations of an immunocompromised patient who presented with vesicular skin findings and elevated transaminases, who quickly progressed to acute liver failure, and had postmortem findings of disseminated VZV infection. |
| format | Article |
| id | doaj-art-c7d93291dbb948e8b53a1fef4548778d |
| institution | OA Journals |
| issn | 2214-2509 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj-art-c7d93291dbb948e8b53a1fef4548778d2025-08-20T02:31:11ZengElsevierIDCases2214-25092025-01-0140e0222410.1016/j.idcr.2025.e02224A rare case of acute liver failure due to disseminated Varicella-Zoster Virus (VZV) infectionHarris T. Feldman0Matthew Neale1Ajay Batra2Mark Mangano3Michael C. Newstein4University of Massachusetts T.H. Chan Medical School, Worcester, MA, USA; Corresponding authors.University of Massachusetts T.H. Chan Medical School, Worcester, MA, USA; Corresponding authors.University of Massachusetts T.H. Chan Medical School, Worcester, MA, USA; Milford Regional Medical Center, Milford, MA, USAUniversity of Massachusetts T.H. Chan Medical School, Worcester, MA, USA; Mass General Brigham, Boston, MA, USAUniversity of Massachusetts T.H. Chan Medical School, Worcester, MA, USA; Milford Regional Medical Center, Milford, MA, USAVaricella zoster virus (VZV) is a human alpha herpes virus that typically manifests in humans with two distinct cutaneous phenotypes: primary varicella, or chickenpox, and secondary reactivation, or Shingles, after establishing latency in the cranial and dorsal root ganglia. VZV infection can present with rarer manifestations including encephalitis, pneumonia, hepatitis, myocarditis, and nephritis. Immunocompromised populations are at the greatest risk for cutaneous and visceral dissemination. The progression of VZV hepatitis to acute liver failure is exceedingly rare, with very few published cases in the literature. In the following case, we report the initial presentation and clinical manifestations of an immunocompromised patient who presented with vesicular skin findings and elevated transaminases, who quickly progressed to acute liver failure, and had postmortem findings of disseminated VZV infection.http://www.sciencedirect.com/science/article/pii/S2214250925000794Varicella zoster virus (VZV)HepatitisLiver failureImmunocompromised |
| spellingShingle | Harris T. Feldman Matthew Neale Ajay Batra Mark Mangano Michael C. Newstein A rare case of acute liver failure due to disseminated Varicella-Zoster Virus (VZV) infection IDCases Varicella zoster virus (VZV) Hepatitis Liver failure Immunocompromised |
| title | A rare case of acute liver failure due to disseminated Varicella-Zoster Virus (VZV) infection |
| title_full | A rare case of acute liver failure due to disseminated Varicella-Zoster Virus (VZV) infection |
| title_fullStr | A rare case of acute liver failure due to disseminated Varicella-Zoster Virus (VZV) infection |
| title_full_unstemmed | A rare case of acute liver failure due to disseminated Varicella-Zoster Virus (VZV) infection |
| title_short | A rare case of acute liver failure due to disseminated Varicella-Zoster Virus (VZV) infection |
| title_sort | rare case of acute liver failure due to disseminated varicella zoster virus vzv infection |
| topic | Varicella zoster virus (VZV) Hepatitis Liver failure Immunocompromised |
| url | http://www.sciencedirect.com/science/article/pii/S2214250925000794 |
| work_keys_str_mv | AT harristfeldman ararecaseofacuteliverfailureduetodisseminatedvaricellazostervirusvzvinfection AT matthewneale ararecaseofacuteliverfailureduetodisseminatedvaricellazostervirusvzvinfection AT ajaybatra ararecaseofacuteliverfailureduetodisseminatedvaricellazostervirusvzvinfection AT markmangano ararecaseofacuteliverfailureduetodisseminatedvaricellazostervirusvzvinfection AT michaelcnewstein ararecaseofacuteliverfailureduetodisseminatedvaricellazostervirusvzvinfection AT harristfeldman rarecaseofacuteliverfailureduetodisseminatedvaricellazostervirusvzvinfection AT matthewneale rarecaseofacuteliverfailureduetodisseminatedvaricellazostervirusvzvinfection AT ajaybatra rarecaseofacuteliverfailureduetodisseminatedvaricellazostervirusvzvinfection AT markmangano rarecaseofacuteliverfailureduetodisseminatedvaricellazostervirusvzvinfection AT michaelcnewstein rarecaseofacuteliverfailureduetodisseminatedvaricellazostervirusvzvinfection |