HOXC6 promotes the metastasis of MSI-H CRC by interacting with M2 macrophages and inducing effector T cell exhaustion

HOXC6 promotes the metastasis of MSI-H CRC by interacting with M2 macrophages and inducing effector T cell exhaustion

Abstract We previously discovered that HOXC6 was the most significantly upregulated gene in right-sided colon cancer compared to left-sided colon cancer according to our previous study; however, the role of HOXC6 in microsatellite instability-high (MSI-H) tumors remains poorly understood. Here, mult...

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Bibliographic Details
Main Authors: Lina Qi, Biting Zhou, Jiani Chen, Kailun Xu, Kailai Wang, Shu Zheng, Wangxiong Hu, Yanmei Yang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cell Communication and Signaling
Subjects:
Colorectal cancer
MSI-H
4-1BB
HOXC6
M2 macrophages
Online Access:https://doi.org/10.1186/s12964-025-02167-2
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