The PI3-kinase/mTOR-targeting drug NVP-BEZ235 inhibits growth and IgE-dependent activation of human mast cells and basophils.

The PI3-kinase/mTOR-targeting drug NVP-BEZ235 inhibits growth and IgE-dependent activation of human mast cells and basophils.

The phosphoinositide 3-kinase (PI3-kinase) and the mammalian target of rapamycin (mTOR) are two major signaling molecules involved in growth and activation of mast cells (MC) and basophils (BA). We examined the effects of the dual PI3-kinase/mTOR blocker NVP-BEZ235 on growth of normal and neoplastic...

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Main Authors: Katharina Blatt, Harald Herrmann, Irina Mirkina, Emir Hadzijusufovic, Barbara Peter, Sabine Strommer, Gregor Hoermann, Matthias Mayerhofer, Konrad Hoetzenecker, Walter Klepetko, Viviane Ghanim, Katharina Marth, Thorsten Füreder, Volker Wacheck, Rudolf Valenta, Peter Valent
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0029925&type=printable
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