A Systematic Review and Meta-Analysis of MIP-1α and MIP-1β Chemokines in Malaria in Relation to Disease Severity
<i>Background and Objectives</i>: Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β act as signaling molecules that recruit immune cells to sites of infection and inflammation. This study aimed to synthesize evidence on blood levels of MIP-1α and MIP-1β in <i>Plasmodium</i&...
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2025-04-01
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| author | Saruda Kuraeiad Kwuntida Uthaisar Kotepui Aongart Mahittikorn Nsoh Godwin Anabire Frederick Ramirez Masangkay Polrat Wilairatana Kinley Wangdi Manas Kotepui |
| author_facet | Saruda Kuraeiad Kwuntida Uthaisar Kotepui Aongart Mahittikorn Nsoh Godwin Anabire Frederick Ramirez Masangkay Polrat Wilairatana Kinley Wangdi Manas Kotepui |
| author_sort | Saruda Kuraeiad |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β act as signaling molecules that recruit immune cells to sites of infection and inflammation. This study aimed to synthesize evidence on blood levels of MIP-1α and MIP-1β in <i>Plasmodium</i>-infected individuals and to determine whether these levels differ between severe and uncomplicated malaria cases. <i>Materials and Methods</i>: The study protocol was registered in PROSPERO (CRD42024595818). Comprehensive literature searches were conducted in six databases (EMBASE, MEDLINE, Ovid, Scopus, ProQuest, and PubMed) to identify studies reporting blood levels of MIP-1α and MIP-1β in <i>Plasmodium</i> infections and clinical malaria. A narrative synthesis was used to describe variations in MIP-1α and MIP-1β levels between malaria patients and controls and between severe and non-severe malaria cases. Meta-analysis was used to aggregate quantitative data utilizing a random-effects model. <i>Results</i>: A total of 1638 records were identified, with 20 studies meeting the inclusion criteria. Most studies reported significantly higher MIP-1α and MIP-1β levels in malaria patients compared to non-malarial controls. The meta-analysis showed a significant elevation in MIP-1α levels in malaria patients (<i>n</i> = 352) compared to uninfected individuals (<i>n</i> = 274) (<i>p</i> = 0.0112, random effects model, standardized mean difference [SMD]: 1.69, 95% confidence interval [CI]: 0.38 to 3.00, <i>I</i><sup>2</sup>: 96.0%, five studies, 626 individuals). The meta-analysis showed no difference in MIP-1α levels between severe malaria cases (<i>n</i> = 203) and uncomplicated cases (<i>n</i> = 106) (<i>p</i> = 0.51, SMD: −0.48, 95% CI: −1.93 to 0.96, <i>I</i><sup>2</sup>: 97.3%, three studies, 309 individuals). <i>Conclusions</i>: This study suggests that while MIP-1α and MIP-1β levels are elevated in malaria patients compared to uninfected individuals, these chemokines show a limited ability to differentiate between severe and uncomplicated malaria or predict severe outcomes. Further research is needed to clarify their role in malaria pathogenesis and explore potential clinical applications. |
| format | Article |
| id | doaj-art-c7d57dfa1b324584a5c2cc69c9bb73f1 |
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| publishDate | 2025-04-01 |
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| spelling | doaj-art-c7d57dfa1b324584a5c2cc69c9bb73f12025-08-20T02:18:09ZengMDPI AGMedicina1010-660X1648-91442025-04-0161467610.3390/medicina61040676A Systematic Review and Meta-Analysis of MIP-1α and MIP-1β Chemokines in Malaria in Relation to Disease SeveritySaruda Kuraeiad0Kwuntida Uthaisar Kotepui1Aongart Mahittikorn2Nsoh Godwin Anabire3Frederick Ramirez Masangkay4Polrat Wilairatana5Kinley Wangdi6Manas Kotepui7Medical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat 80160, ThailandMedical Technology, Faculty of Science, Nakhon Phanom University, Nakhon Phanom 48000, ThailandDepartment of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, ThailandDepartment of Biochemistry & Molecular Medicine, School of Medicine, University for Development Studies, Tamale P.O. Box TL 1882, GhanaDepartment of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, Manila 1008, PhilippinesDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, ThailandHEAL Global Research Centre, Health Research Centre, Faculty of Health, University of Canberra, Canberra, ACT 2617, AustraliaMedical Technology, Faculty of Science, Nakhon Phanom University, Nakhon Phanom 48000, Thailand<i>Background and Objectives</i>: Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β act as signaling molecules that recruit immune cells to sites of infection and inflammation. This study aimed to synthesize evidence on blood levels of MIP-1α and MIP-1β in <i>Plasmodium</i>-infected individuals and to determine whether these levels differ between severe and uncomplicated malaria cases. <i>Materials and Methods</i>: The study protocol was registered in PROSPERO (CRD42024595818). Comprehensive literature searches were conducted in six databases (EMBASE, MEDLINE, Ovid, Scopus, ProQuest, and PubMed) to identify studies reporting blood levels of MIP-1α and MIP-1β in <i>Plasmodium</i> infections and clinical malaria. A narrative synthesis was used to describe variations in MIP-1α and MIP-1β levels between malaria patients and controls and between severe and non-severe malaria cases. Meta-analysis was used to aggregate quantitative data utilizing a random-effects model. <i>Results</i>: A total of 1638 records were identified, with 20 studies meeting the inclusion criteria. Most studies reported significantly higher MIP-1α and MIP-1β levels in malaria patients compared to non-malarial controls. The meta-analysis showed a significant elevation in MIP-1α levels in malaria patients (<i>n</i> = 352) compared to uninfected individuals (<i>n</i> = 274) (<i>p</i> = 0.0112, random effects model, standardized mean difference [SMD]: 1.69, 95% confidence interval [CI]: 0.38 to 3.00, <i>I</i><sup>2</sup>: 96.0%, five studies, 626 individuals). The meta-analysis showed no difference in MIP-1α levels between severe malaria cases (<i>n</i> = 203) and uncomplicated cases (<i>n</i> = 106) (<i>p</i> = 0.51, SMD: −0.48, 95% CI: −1.93 to 0.96, <i>I</i><sup>2</sup>: 97.3%, three studies, 309 individuals). <i>Conclusions</i>: This study suggests that while MIP-1α and MIP-1β levels are elevated in malaria patients compared to uninfected individuals, these chemokines show a limited ability to differentiate between severe and uncomplicated malaria or predict severe outcomes. Further research is needed to clarify their role in malaria pathogenesis and explore potential clinical applications.https://www.mdpi.com/1648-9144/61/4/676systematic reviewmeta-analysismacrophage inflammatory proteinMIP-1αMIP-1βmalaria |
| spellingShingle | Saruda Kuraeiad Kwuntida Uthaisar Kotepui Aongart Mahittikorn Nsoh Godwin Anabire Frederick Ramirez Masangkay Polrat Wilairatana Kinley Wangdi Manas Kotepui A Systematic Review and Meta-Analysis of MIP-1α and MIP-1β Chemokines in Malaria in Relation to Disease Severity Medicina systematic review meta-analysis macrophage inflammatory protein MIP-1α MIP-1β malaria |
| title | A Systematic Review and Meta-Analysis of MIP-1α and MIP-1β Chemokines in Malaria in Relation to Disease Severity |
| title_full | A Systematic Review and Meta-Analysis of MIP-1α and MIP-1β Chemokines in Malaria in Relation to Disease Severity |
| title_fullStr | A Systematic Review and Meta-Analysis of MIP-1α and MIP-1β Chemokines in Malaria in Relation to Disease Severity |
| title_full_unstemmed | A Systematic Review and Meta-Analysis of MIP-1α and MIP-1β Chemokines in Malaria in Relation to Disease Severity |
| title_short | A Systematic Review and Meta-Analysis of MIP-1α and MIP-1β Chemokines in Malaria in Relation to Disease Severity |
| title_sort | systematic review and meta analysis of mip 1α and mip 1β chemokines in malaria in relation to disease severity |
| topic | systematic review meta-analysis macrophage inflammatory protein MIP-1α MIP-1β malaria |
| url | https://www.mdpi.com/1648-9144/61/4/676 |
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