Pentraxin 3(PTX 3): An Endogenous Modulator of the Inflammatory Response
Inflammatory or anti-inflammatory? That is the question as far as the acute-phase response and its mediators, the pentraxins, are concerned. Only some ten years ago, the classical or short pentraxin C-reactive protein and the newly discovered long pentraxin PTX3 were considered to exert most of the...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/920517 |
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| author | P. Kunes Z. Holubcova M. Kolackova J. Krejsek |
| author_facet | P. Kunes Z. Holubcova M. Kolackova J. Krejsek |
| author_sort | P. Kunes |
| collection | DOAJ |
| description | Inflammatory or anti-inflammatory? That is the question as far as the acute-phase response and its mediators, the pentraxins, are concerned. Only some ten years ago, the classical or short pentraxin C-reactive protein and the newly discovered long pentraxin PTX3 were considered to exert most of the detrimental effects of acute inflammation, whether microbial or sterile in origin. However, accumulating evidence suggests an at least dichotomous, context-dependent outcome attributable to the pentraxins, if not a straightforward anti-inflammatory nature of the acute-phase response. This paper is focused on the inherent effects of pentraxin 3 in inflammatory responses, mainly in coronary artery disease and in Aspergillus fumigatus infection. Both are examples of inflammatory reactions in which PTX3 is substantially involved; the former sterile, the latter infectious in origin. Apart from different inducing noxae, similarities in the pathogenesis of the two are striking. All the same, the introductory question still persists: is the ultimate impact of PTX3 in these conditions inflammatory or anti-inflammatory, paradoxical as the latter might appear? We try to provide an answer such as it emerges in the light of recent findings. |
| format | Article |
| id | doaj-art-c7d3e2758afc4757a91a2e0c91d3a7b9 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c7d3e2758afc4757a91a2e0c91d3a7b92025-08-20T03:24:11ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/920517920517Pentraxin 3(PTX 3): An Endogenous Modulator of the Inflammatory ResponseP. Kunes0Z. Holubcova1M. Kolackova2J. Krejsek3Department of Cardiac Surgery, University Hospital and Medical School of Hradec Kralove, Charles University in Prague, 12843 Prague, Czech RepublicDepartment of Cardiac Surgery, University Hospital and Medical School of Hradec Kralove, Charles University in Prague, 12843 Prague, Czech RepublicDepartment of Clinical Immunology and Allergology, University Hospital and Medical School of Hradec Kralove, Charles University in Prague, 12843 Prague, Czech RepublicDepartment of Clinical Immunology and Allergology, University Hospital and Medical School of Hradec Kralove, Charles University in Prague, 12843 Prague, Czech RepublicInflammatory or anti-inflammatory? That is the question as far as the acute-phase response and its mediators, the pentraxins, are concerned. Only some ten years ago, the classical or short pentraxin C-reactive protein and the newly discovered long pentraxin PTX3 were considered to exert most of the detrimental effects of acute inflammation, whether microbial or sterile in origin. However, accumulating evidence suggests an at least dichotomous, context-dependent outcome attributable to the pentraxins, if not a straightforward anti-inflammatory nature of the acute-phase response. This paper is focused on the inherent effects of pentraxin 3 in inflammatory responses, mainly in coronary artery disease and in Aspergillus fumigatus infection. Both are examples of inflammatory reactions in which PTX3 is substantially involved; the former sterile, the latter infectious in origin. Apart from different inducing noxae, similarities in the pathogenesis of the two are striking. All the same, the introductory question still persists: is the ultimate impact of PTX3 in these conditions inflammatory or anti-inflammatory, paradoxical as the latter might appear? We try to provide an answer such as it emerges in the light of recent findings.http://dx.doi.org/10.1155/2012/920517 |
| spellingShingle | P. Kunes Z. Holubcova M. Kolackova J. Krejsek Pentraxin 3(PTX 3): An Endogenous Modulator of the Inflammatory Response Mediators of Inflammation |
| title | Pentraxin 3(PTX 3): An Endogenous Modulator of the Inflammatory Response |
| title_full | Pentraxin 3(PTX 3): An Endogenous Modulator of the Inflammatory Response |
| title_fullStr | Pentraxin 3(PTX 3): An Endogenous Modulator of the Inflammatory Response |
| title_full_unstemmed | Pentraxin 3(PTX 3): An Endogenous Modulator of the Inflammatory Response |
| title_short | Pentraxin 3(PTX 3): An Endogenous Modulator of the Inflammatory Response |
| title_sort | pentraxin 3 ptx 3 an endogenous modulator of the inflammatory response |
| url | http://dx.doi.org/10.1155/2012/920517 |
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