Generation of the CSSi020-A (14437) iPSC line from a patient carrying a copy number variation (CNV) in the 17p11.2 chromosome region

Smith-Magenis syndrome (SMS) is a complex neurodevelopmental disorder with a birth incidence of 1:25,000. SMS is caused by haploinsufficiency of the retinoic acid-induced retinoic acid1 (RAI1) gene, determined by an interstitial deletion of ∼ 3.7 Mb (17p11.2, including the RAI1 gene) in 90 % of case...

Full description

Saved in:
Bibliographic Details
Main Authors: Angela Maria Giada Giovenale, Elisa Maria Turco, Martina Mazzoni, Ilaria Ferrone, Barbara Torres, Laura Bernardini, Edvige Vulcano, Daniela Ferrari, Roberta Onesimo, Stefano D’Arrigo, Giuseppe Zampino, Maria Pennuto, Alessandro De Luca, Angelo Luigi Vescovi, Jessica Rosati
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506124002423
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1850245045625552896
author Angela Maria Giada Giovenale
Elisa Maria Turco
Martina Mazzoni
Ilaria Ferrone
Barbara Torres
Laura Bernardini
Edvige Vulcano
Daniela Ferrari
Roberta Onesimo
Stefano D’Arrigo
Giuseppe Zampino
Maria Pennuto
Alessandro De Luca
Angelo Luigi Vescovi
Jessica Rosati
author_facet Angela Maria Giada Giovenale
Elisa Maria Turco
Martina Mazzoni
Ilaria Ferrone
Barbara Torres
Laura Bernardini
Edvige Vulcano
Daniela Ferrari
Roberta Onesimo
Stefano D’Arrigo
Giuseppe Zampino
Maria Pennuto
Alessandro De Luca
Angelo Luigi Vescovi
Jessica Rosati
author_sort Angela Maria Giada Giovenale
collection DOAJ
description Smith-Magenis syndrome (SMS) is a complex neurodevelopmental disorder with a birth incidence of 1:25,000. SMS is caused by haploinsufficiency of the retinoic acid-induced retinoic acid1 (RAI1) gene, determined by an interstitial deletion of ∼ 3.7 Mb (17p11.2, including the RAI1 gene) in 90 % of cases and a mutation on the RAI1 gene in only 10 % of cases. We generated and characterized a human pluripotent stem cell line (hIPSCs) derived from primary fibroblasts of a 17-year-old woman carrying a 17p11.2 deletion including the RAI1 gene.
format Article
id doaj-art-c7d1741ad7fa4ba3a093621038ca309c
institution OA Journals
issn 1873-5061
language English
publishDate 2024-12-01
publisher Elsevier
record_format Article
series Stem Cell Research
spelling doaj-art-c7d1741ad7fa4ba3a093621038ca309c2025-08-20T01:59:34ZengElsevierStem Cell Research1873-50612024-12-018110354410.1016/j.scr.2024.103544Generation of the CSSi020-A (14437) iPSC line from a patient carrying a copy number variation (CNV) in the 17p11.2 chromosome regionAngela Maria Giada Giovenale0Elisa Maria Turco1Martina Mazzoni2Ilaria Ferrone3Barbara Torres4Laura Bernardini5Edvige Vulcano6Daniela Ferrari7Roberta Onesimo8Stefano D’Arrigo9Giuseppe Zampino10Maria Pennuto11Alessandro De Luca12Angelo Luigi Vescovi13Jessica Rosati14Cellular Reprogramming Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale dei Cappuccini, 71013 San Giovanni Rotondo, FG Italy; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, ItalyCellular Reprogramming Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale dei Cappuccini, 71013 San Giovanni Rotondo, FG ItalyCellular Reprogramming Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale dei Cappuccini, 71013 San Giovanni Rotondo, FG ItalyCellular Reprogramming Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale dei Cappuccini, 71013 San Giovanni Rotondo, FG ItalyMedical Genetics Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale dei Cappuccini, 71013 San Giovanni Rotondo, ItalyMedical Genetics Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale dei Cappuccini, 71013 San Giovanni Rotondo, ItalyDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, ItalyDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, ItalyRare Diseases and Birth Defects Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, ItalyDepartment of Pediatric Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Giovanni Celoria, 11, 20133 Milano, ItalyRare Diseases and Birth Defects Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy; Dipartimento di Scienze della Vita e Sanità Pubblica, Università Cattolica del S. Cuore, Largo Francesco Vito, 1, 00168 Rome, ItalyVeneto Institute of Molecular Medicine (VIMM), via Orus 2, 35129 Padova, Italy; Department of Biomedical Sciences, University of Padova, via Ugo Bassi 58/B, 35131 Padova, ItalyMedical Genetics Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale dei Cappuccini, 71013 San Giovanni Rotondo, ItalyCellular Reprogramming Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale dei Cappuccini, 71013 San Giovanni Rotondo, FG ItalyCellular Reprogramming Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale dei Cappuccini, 71013 San Giovanni Rotondo, FG Italy; Corresponding author.Smith-Magenis syndrome (SMS) is a complex neurodevelopmental disorder with a birth incidence of 1:25,000. SMS is caused by haploinsufficiency of the retinoic acid-induced retinoic acid1 (RAI1) gene, determined by an interstitial deletion of ∼ 3.7 Mb (17p11.2, including the RAI1 gene) in 90 % of cases and a mutation on the RAI1 gene in only 10 % of cases. We generated and characterized a human pluripotent stem cell line (hIPSCs) derived from primary fibroblasts of a 17-year-old woman carrying a 17p11.2 deletion including the RAI1 gene.http://www.sciencedirect.com/science/article/pii/S1873506124002423
spellingShingle Angela Maria Giada Giovenale
Elisa Maria Turco
Martina Mazzoni
Ilaria Ferrone
Barbara Torres
Laura Bernardini
Edvige Vulcano
Daniela Ferrari
Roberta Onesimo
Stefano D’Arrigo
Giuseppe Zampino
Maria Pennuto
Alessandro De Luca
Angelo Luigi Vescovi
Jessica Rosati
Generation of the CSSi020-A (14437) iPSC line from a patient carrying a copy number variation (CNV) in the 17p11.2 chromosome region
Stem Cell Research
title Generation of the CSSi020-A (14437) iPSC line from a patient carrying a copy number variation (CNV) in the 17p11.2 chromosome region
title_full Generation of the CSSi020-A (14437) iPSC line from a patient carrying a copy number variation (CNV) in the 17p11.2 chromosome region
title_fullStr Generation of the CSSi020-A (14437) iPSC line from a patient carrying a copy number variation (CNV) in the 17p11.2 chromosome region
title_full_unstemmed Generation of the CSSi020-A (14437) iPSC line from a patient carrying a copy number variation (CNV) in the 17p11.2 chromosome region
title_short Generation of the CSSi020-A (14437) iPSC line from a patient carrying a copy number variation (CNV) in the 17p11.2 chromosome region
title_sort generation of the cssi020 a 14437 ipsc line from a patient carrying a copy number variation cnv in the 17p11 2 chromosome region
url http://www.sciencedirect.com/science/article/pii/S1873506124002423
work_keys_str_mv AT angelamariagiadagiovenale generationofthecssi020a14437ipsclinefromapatientcarryingacopynumbervariationcnvinthe17p112chromosomeregion
AT elisamariaturco generationofthecssi020a14437ipsclinefromapatientcarryingacopynumbervariationcnvinthe17p112chromosomeregion
AT martinamazzoni generationofthecssi020a14437ipsclinefromapatientcarryingacopynumbervariationcnvinthe17p112chromosomeregion
AT ilariaferrone generationofthecssi020a14437ipsclinefromapatientcarryingacopynumbervariationcnvinthe17p112chromosomeregion
AT barbaratorres generationofthecssi020a14437ipsclinefromapatientcarryingacopynumbervariationcnvinthe17p112chromosomeregion
AT laurabernardini generationofthecssi020a14437ipsclinefromapatientcarryingacopynumbervariationcnvinthe17p112chromosomeregion
AT edvigevulcano generationofthecssi020a14437ipsclinefromapatientcarryingacopynumbervariationcnvinthe17p112chromosomeregion
AT danielaferrari generationofthecssi020a14437ipsclinefromapatientcarryingacopynumbervariationcnvinthe17p112chromosomeregion
AT robertaonesimo generationofthecssi020a14437ipsclinefromapatientcarryingacopynumbervariationcnvinthe17p112chromosomeregion
AT stefanodarrigo generationofthecssi020a14437ipsclinefromapatientcarryingacopynumbervariationcnvinthe17p112chromosomeregion
AT giuseppezampino generationofthecssi020a14437ipsclinefromapatientcarryingacopynumbervariationcnvinthe17p112chromosomeregion
AT mariapennuto generationofthecssi020a14437ipsclinefromapatientcarryingacopynumbervariationcnvinthe17p112chromosomeregion
AT alessandrodeluca generationofthecssi020a14437ipsclinefromapatientcarryingacopynumbervariationcnvinthe17p112chromosomeregion
AT angeloluigivescovi generationofthecssi020a14437ipsclinefromapatientcarryingacopynumbervariationcnvinthe17p112chromosomeregion
AT jessicarosati generationofthecssi020a14437ipsclinefromapatientcarryingacopynumbervariationcnvinthe17p112chromosomeregion