The Edinburgh human metabolic network reconstruction and its functional analysis
Abstract A better understanding of human metabolism and its relationship with diseases is an important task in human systems biology studies. In this paper, we present a high‐quality human metabolic network manually reconstructed by integrating genome annotation information from different databases...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2007-09-01
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| Series: | Molecular Systems Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/msb4100177 |
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| _version_ | 1849225795494477824 |
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| author | Hongwu Ma Anatoly Sorokin Alexander Mazein Alex Selkov Evgeni Selkov Oleg Demin Igor Goryanin |
| author_facet | Hongwu Ma Anatoly Sorokin Alexander Mazein Alex Selkov Evgeni Selkov Oleg Demin Igor Goryanin |
| author_sort | Hongwu Ma |
| collection | DOAJ |
| description | Abstract A better understanding of human metabolism and its relationship with diseases is an important task in human systems biology studies. In this paper, we present a high‐quality human metabolic network manually reconstructed by integrating genome annotation information from different databases and metabolic reaction information from literature. The network contains nearly 3000 metabolic reactions, which were reorganized into about 70 human‐specific metabolic pathways according to their functional relationships. By analysis of the functional connectivity of the metabolites in the network, the bow‐tie structure, which was found previously by structure analysis, is reconfirmed. Furthermore, the distribution of the disease related genes in the network suggests that the IN (substrates) subset of the bow‐tie structure has more flexibility than other parts. |
| format | Article |
| id | doaj-art-c7cdc449f7194a83aed778e264fd4e6b |
| institution | Kabale University |
| issn | 1744-4292 |
| language | English |
| publishDate | 2007-09-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | Molecular Systems Biology |
| spelling | doaj-art-c7cdc449f7194a83aed778e264fd4e6b2025-08-24T12:02:03ZengSpringer NatureMolecular Systems Biology1744-42922007-09-01311810.1038/msb4100177The Edinburgh human metabolic network reconstruction and its functional analysisHongwu Ma0Anatoly Sorokin1Alexander Mazein2Alex Selkov3Evgeni Selkov4Oleg Demin5Igor Goryanin6Computational Systems Biology, School of Informatics, The University of EdinburghComputational Systems Biology, School of Informatics, The University of EdinburghComputational Systems Biology, School of Informatics, The University of EdinburghEMP Project Inc.EMP Project Inc.Institute for Systems Biology SPb, Leninskie Gory, Moscow State UniversityComputational Systems Biology, School of Informatics, The University of EdinburghAbstract A better understanding of human metabolism and its relationship with diseases is an important task in human systems biology studies. In this paper, we present a high‐quality human metabolic network manually reconstructed by integrating genome annotation information from different databases and metabolic reaction information from literature. The network contains nearly 3000 metabolic reactions, which were reorganized into about 70 human‐specific metabolic pathways according to their functional relationships. By analysis of the functional connectivity of the metabolites in the network, the bow‐tie structure, which was found previously by structure analysis, is reconfirmed. Furthermore, the distribution of the disease related genes in the network suggests that the IN (substrates) subset of the bow‐tie structure has more flexibility than other parts.https://doi.org/10.1038/msb4100177bow‐tiehumanmetabolic networkpathway |
| spellingShingle | Hongwu Ma Anatoly Sorokin Alexander Mazein Alex Selkov Evgeni Selkov Oleg Demin Igor Goryanin The Edinburgh human metabolic network reconstruction and its functional analysis Molecular Systems Biology bow‐tie human metabolic network pathway |
| title | The Edinburgh human metabolic network reconstruction and its functional analysis |
| title_full | The Edinburgh human metabolic network reconstruction and its functional analysis |
| title_fullStr | The Edinburgh human metabolic network reconstruction and its functional analysis |
| title_full_unstemmed | The Edinburgh human metabolic network reconstruction and its functional analysis |
| title_short | The Edinburgh human metabolic network reconstruction and its functional analysis |
| title_sort | edinburgh human metabolic network reconstruction and its functional analysis |
| topic | bow‐tie human metabolic network pathway |
| url | https://doi.org/10.1038/msb4100177 |
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