18F-fluorodeoxyglucose PET/CT scans for thoracic tuberculosis: current evidence and future perspectives
The advent of positron emission tomography (PET) combined with computed tomography (CT) in the field of inflammatory/infectious diseases heralds an era of personalised disease management using these noninvasive technologies. This nuclear medicine technique can be a useful tool in tuberculosis (TB) f...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2025-06-01
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| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/content/34/176/240289.full |
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| author | Ana Paula Santos Rosana Souza Rodrigues Erik H.J.G. Aarntzen Paulo Henrique Rosado de Castro Cecile Magis-Escurra Fernanda Carvalho de Queiroz Mello |
| author_facet | Ana Paula Santos Rosana Souza Rodrigues Erik H.J.G. Aarntzen Paulo Henrique Rosado de Castro Cecile Magis-Escurra Fernanda Carvalho de Queiroz Mello |
| author_sort | Ana Paula Santos |
| collection | DOAJ |
| description | The advent of positron emission tomography (PET) combined with computed tomography (CT) in the field of inflammatory/infectious diseases heralds an era of personalised disease management using these noninvasive technologies. This nuclear medicine technique can be a useful tool in tuberculosis (TB) for assessing the extent of extrapulmonary disease, evaluating treatment response and identifying patients at higher risk of disease relapse. The fusion of functional imaging provided by PET with the anatomical and morphological details captured by CT has enabled clinicians to better understand the dynamics of the pathophysiology and natural course of Mycobacterium tuberculosis infection. Using its whole-body field of view, host responses are most commonly visualised using 18F-fluorodeoxyglucose, which reflects the glycolytic activity of cells. The strict indications for PET/CT in TB are matched by the caution required in interpreting its qualitative, quantitative and volumetric imaging patterns. In this narrative review, we aim to summarise evidence supporting the use of this molecular imaging modality in thoracic presentations of TB, particularly pulmonary and lymph node involvement, together with concepts to aid in the reporting and interpretation of the tests. We will also explore future indications for PET/CT in TB and discuss challenges to its routine use. |
| format | Article |
| id | doaj-art-c7cd740e532a4fa0b7bffda779663268 |
| institution | DOAJ |
| issn | 0905-9180 1600-0617 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj-art-c7cd740e532a4fa0b7bffda7796632682025-08-20T03:14:49ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172025-06-013417610.1183/16000617.0289-20240289-202418F-fluorodeoxyglucose PET/CT scans for thoracic tuberculosis: current evidence and future perspectivesAna Paula Santos0Rosana Souza Rodrigues1Erik H.J.G. Aarntzen2Paulo Henrique Rosado de Castro3Cecile Magis-Escurra4Fernanda Carvalho de Queiroz Mello5 Federal University of Rio de Janeiro, Thoracic Diseases Institute, Rio de Janeiro, Brazil Federal University of Rio de Janeiro, Clementino Fraga Filho University Hospital, Radiology Department, Rio de Janeiro, Brazil Groningen University, Department of Nuclear Medicine and Molecular Imaging, Groningen, The Netherlands D'Or Institute for Research and Education, Rio de Janeiro, Brazil Radboud University Medical Center, Department of Respiratory Diseases-TB Expert Center Dekkerswald, Nijmegen, The Netherlands Federal University of Rio de Janeiro, Thoracic Diseases Institute, Rio de Janeiro, Brazil The advent of positron emission tomography (PET) combined with computed tomography (CT) in the field of inflammatory/infectious diseases heralds an era of personalised disease management using these noninvasive technologies. This nuclear medicine technique can be a useful tool in tuberculosis (TB) for assessing the extent of extrapulmonary disease, evaluating treatment response and identifying patients at higher risk of disease relapse. The fusion of functional imaging provided by PET with the anatomical and morphological details captured by CT has enabled clinicians to better understand the dynamics of the pathophysiology and natural course of Mycobacterium tuberculosis infection. Using its whole-body field of view, host responses are most commonly visualised using 18F-fluorodeoxyglucose, which reflects the glycolytic activity of cells. The strict indications for PET/CT in TB are matched by the caution required in interpreting its qualitative, quantitative and volumetric imaging patterns. In this narrative review, we aim to summarise evidence supporting the use of this molecular imaging modality in thoracic presentations of TB, particularly pulmonary and lymph node involvement, together with concepts to aid in the reporting and interpretation of the tests. We will also explore future indications for PET/CT in TB and discuss challenges to its routine use.http://err.ersjournals.com/content/34/176/240289.full |
| spellingShingle | Ana Paula Santos Rosana Souza Rodrigues Erik H.J.G. Aarntzen Paulo Henrique Rosado de Castro Cecile Magis-Escurra Fernanda Carvalho de Queiroz Mello 18F-fluorodeoxyglucose PET/CT scans for thoracic tuberculosis: current evidence and future perspectives European Respiratory Review |
| title | 18F-fluorodeoxyglucose PET/CT scans for thoracic tuberculosis: current evidence and future perspectives |
| title_full | 18F-fluorodeoxyglucose PET/CT scans for thoracic tuberculosis: current evidence and future perspectives |
| title_fullStr | 18F-fluorodeoxyglucose PET/CT scans for thoracic tuberculosis: current evidence and future perspectives |
| title_full_unstemmed | 18F-fluorodeoxyglucose PET/CT scans for thoracic tuberculosis: current evidence and future perspectives |
| title_short | 18F-fluorodeoxyglucose PET/CT scans for thoracic tuberculosis: current evidence and future perspectives |
| title_sort | 18f fluorodeoxyglucose pet ct scans for thoracic tuberculosis current evidence and future perspectives |
| url | http://err.ersjournals.com/content/34/176/240289.full |
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