Congenital long-QT syndrome in type 1 diabetes: a unique association
In contrast to acquired long QT syndrome (LQTS), congenital LQTS is a relatively rare channelopathy with an incidence of 1/2,500. We describe a patient found to have a prolonged QTc in the setting of newly diagnosed Type 1 DM. To the best of our knowledge, this unique association has not been previ...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2019-10-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/771 |
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| author | Erdal Kurnaz Şenay Savaş Erdeve Senem Özgür Melikşah Keskin Pınar Özbudak Semra Çetinkaya Zehra Aycan |
| author_facet | Erdal Kurnaz Şenay Savaş Erdeve Senem Özgür Melikşah Keskin Pınar Özbudak Semra Çetinkaya Zehra Aycan |
| author_sort | Erdal Kurnaz |
| collection | DOAJ |
| description |
In contrast to acquired long QT syndrome (LQTS), congenital LQTS is a relatively rare channelopathy with an incidence of 1/2,500. We describe a patient found to have a prolonged QTc in the setting of newly diagnosed Type 1 DM. To the best of our knowledge, this unique association has not been previously reported. Currently, it is shown that glucose ingestion aggravated cardiac repolarization disturbances in LQT2 patients and prolonged the cardiac repolarization phase in healthy controls. Our case presented to the hospital with syncope after increased glucose level. Therefore, it seems that increased glucose level may have prolonged QTc interval and aggravated cardiac repolarization disturbances in the presented case. By this report, we want to emphasize the importance of hyperglycaemia in congenital LQTS.
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| format | Article |
| id | doaj-art-c7c4c9bc78ff446ba20fb72104b5d2e5 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2019-10-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-c7c4c9bc78ff446ba20fb72104b5d2e52025-08-20T02:01:54ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212019-10-0161510.24953/turkjped.2019.05.022Congenital long-QT syndrome in type 1 diabetes: a unique associationErdal Kurnaz0Şenay Savaş Erdeve1Senem Özgür2Melikşah Keskin3Pınar Özbudak4Semra Çetinkaya5Zehra Aycan6Pediatric Endocrinology Clinic, Dr. Sami Ulus Obstetrics and Gynecology and Pediatrics Training and Research Hospital, Ankara, Turkey.Pediatric Endocrinology Clinic, Dr. Sami Ulus Obstetrics and Gynecology and Pediatrics Training and Research Hospital, Ankara, Turkey.Pediatric Cardiology Clinic, Dr. Sami Ulus Obstetrics and Gynecology and Pediatrics Training and Research Hospital, Ankara, Turkey.Pediatric Endocrinology Clinic, Dr. Sami Ulus Obstetrics and Gynecology and Pediatrics Training and Research Hospital, Ankara, Turkey.Pediatric Endocrinology Clinic, Dr. Sami Ulus Obstetrics and Gynecology and Pediatrics Training and Research Hospital, Ankara, Turkey.Pediatric Endocrinology Clinic, Dr. Sami Ulus Obstetrics and Gynecology and Pediatrics Training and Research Hospital, Ankara, Turkey.Pediatric Endocrinology Clinic, Dr. Sami Ulus Obstetrics and Gynecology and Pediatrics Training and Research Hospital, Ankara, Turkey. In contrast to acquired long QT syndrome (LQTS), congenital LQTS is a relatively rare channelopathy with an incidence of 1/2,500. We describe a patient found to have a prolonged QTc in the setting of newly diagnosed Type 1 DM. To the best of our knowledge, this unique association has not been previously reported. Currently, it is shown that glucose ingestion aggravated cardiac repolarization disturbances in LQT2 patients and prolonged the cardiac repolarization phase in healthy controls. Our case presented to the hospital with syncope after increased glucose level. Therefore, it seems that increased glucose level may have prolonged QTc interval and aggravated cardiac repolarization disturbances in the presented case. By this report, we want to emphasize the importance of hyperglycaemia in congenital LQTS. https://turkjpediatr.org/article/view/771cardiac arrhythmiasdiabeteslong QT |
| spellingShingle | Erdal Kurnaz Şenay Savaş Erdeve Senem Özgür Melikşah Keskin Pınar Özbudak Semra Çetinkaya Zehra Aycan Congenital long-QT syndrome in type 1 diabetes: a unique association The Turkish Journal of Pediatrics cardiac arrhythmias diabetes long QT |
| title | Congenital long-QT syndrome in type 1 diabetes: a unique association |
| title_full | Congenital long-QT syndrome in type 1 diabetes: a unique association |
| title_fullStr | Congenital long-QT syndrome in type 1 diabetes: a unique association |
| title_full_unstemmed | Congenital long-QT syndrome in type 1 diabetes: a unique association |
| title_short | Congenital long-QT syndrome in type 1 diabetes: a unique association |
| title_sort | congenital long qt syndrome in type 1 diabetes a unique association |
| topic | cardiac arrhythmias diabetes long QT |
| url | https://turkjpediatr.org/article/view/771 |
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