Punica granatum L. Leaf Extract Attenuates Lung Inflammation in Mice with Acute Lung Injury
The hydroalcoholic extract of Punica granatum (pomegranate) leaves was previously demonstrated to be anti-inflammatory in a rat model of lipopolysaccharide- (LPS-) induced acute peritonitis. Here, we investigated the anti-inflammatory effects of the ethyl acetate fraction obtained from the pomegrana...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/6879183 |
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| author | Aruanã Joaquim Matheus Costa Rodrigues Pinheiro Jaciara Sá Gonçalves Ádylla Wilenna Alves Dourado Eduardo Martins de Sousa Natilene Mesquita Brito Lanna Karinny Silva Marisa Cristina Aranha Batista Joicy Cortez de Sá Cinara Regina Aragão Vieira Monteiro Elizabeth Soares Fernandes Valério Monteiro-Neto Lee Ann Campbell Patrícia Maria Wiziack Zago Lidio Gonçalves Lima-Neto |
| author_facet | Aruanã Joaquim Matheus Costa Rodrigues Pinheiro Jaciara Sá Gonçalves Ádylla Wilenna Alves Dourado Eduardo Martins de Sousa Natilene Mesquita Brito Lanna Karinny Silva Marisa Cristina Aranha Batista Joicy Cortez de Sá Cinara Regina Aragão Vieira Monteiro Elizabeth Soares Fernandes Valério Monteiro-Neto Lee Ann Campbell Patrícia Maria Wiziack Zago Lidio Gonçalves Lima-Neto |
| author_sort | Aruanã Joaquim Matheus Costa Rodrigues Pinheiro |
| collection | DOAJ |
| description | The hydroalcoholic extract of Punica granatum (pomegranate) leaves was previously demonstrated to be anti-inflammatory in a rat model of lipopolysaccharide- (LPS-) induced acute peritonitis. Here, we investigated the anti-inflammatory effects of the ethyl acetate fraction obtained from the pomegranate leaf hydroalcoholic extract (EAFPg) on the LPS-induced acute lung injury (ALI) mouse model. Male Swiss mice received either EAFPg at different doses or dexamethasone (per os) prior to LPS intranasal instillation. Vehicle-treated mice were used as controls. Animals were culled at 4 h after LPS challenge, and the bronchoalveolar lavage fluid (BALF) and lung samples were collected for analysis. EAFPg and kaempferol effects on NO and cytokine production by LPS-stimulated RAW 264.7 macrophages were also investigated. Pretreatment with EAFPg (100–300 mg/kg) markedly reduced cell accumulation (specially neutrophils) and collagen deposition in the lungs of ALI mice. The same animals presented with reduced lung and BALF TNF-α and IL-1β expression in comparison with vehicle controls (p<0.05). Additionally, incubation with either EAFPg or kaempferol (100 μg/ml) reduced NO production and cytokine gene expression in cultured LPS-treated RAW 264.7 macrophages. Overall, these results demonstrate that the prophylactic treatment with EAFPg attenuates acute lung inflammation. We suggest this fraction may be useful in treating ALI. |
| format | Article |
| id | doaj-art-c7c4b0ccc1d6418ca8f19731d013e8fb |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c7c4b0ccc1d6418ca8f19731d013e8fb2025-08-20T03:24:11ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/68791836879183Punica granatum L. Leaf Extract Attenuates Lung Inflammation in Mice with Acute Lung InjuryAruanã Joaquim Matheus Costa Rodrigues Pinheiro0Jaciara Sá Gonçalves1Ádylla Wilenna Alves Dourado2Eduardo Martins de Sousa3Natilene Mesquita Brito4Lanna Karinny Silva5Marisa Cristina Aranha Batista6Joicy Cortez de Sá7Cinara Regina Aragão Vieira Monteiro8Elizabeth Soares Fernandes9Valério Monteiro-Neto10Lee Ann Campbell11Patrícia Maria Wiziack Zago12Lidio Gonçalves Lima-Neto13Programa de Pós-Graduação, Universidade CEUMA, São Luís, MA, BrazilPrograma de Pós-Graduação, Universidade CEUMA, São Luís, MA, BrazilPrograma de Pós-Graduação, Universidade CEUMA, São Luís, MA, BrazilPrograma de Pós-Graduação, Universidade CEUMA, São Luís, MA, BrazilLaboratório de Estudos Ambientais, Instituto Federal do Maranhão, São Luís, MA, BrazilLaboratório de Estudos Ambientais, Instituto Federal do Maranhão, São Luís, MA, BrazilLaboratório de Farmacognosia I, Universidade Federal do Maranhão, São Luís, MA, BrazilDepartamento de Medicina, Universidade CEUMA, São Luís, MA, BrazilPrograma de Pós-Graduação, Universidade CEUMA, São Luís, MA, BrazilPrograma de Pós-Graduação, Universidade CEUMA, São Luís, MA, BrazilPrograma de Pós-Graduação, Universidade CEUMA, São Luís, MA, BrazilDepartment of Global Health, University of Washington, Seattle, WA, USADepartamento de Odontologia, Universidade CEUMA, São Luís, MA, BrazilPrograma de Pós-Graduação, Universidade CEUMA, São Luís, MA, BrazilThe hydroalcoholic extract of Punica granatum (pomegranate) leaves was previously demonstrated to be anti-inflammatory in a rat model of lipopolysaccharide- (LPS-) induced acute peritonitis. Here, we investigated the anti-inflammatory effects of the ethyl acetate fraction obtained from the pomegranate leaf hydroalcoholic extract (EAFPg) on the LPS-induced acute lung injury (ALI) mouse model. Male Swiss mice received either EAFPg at different doses or dexamethasone (per os) prior to LPS intranasal instillation. Vehicle-treated mice were used as controls. Animals were culled at 4 h after LPS challenge, and the bronchoalveolar lavage fluid (BALF) and lung samples were collected for analysis. EAFPg and kaempferol effects on NO and cytokine production by LPS-stimulated RAW 264.7 macrophages were also investigated. Pretreatment with EAFPg (100–300 mg/kg) markedly reduced cell accumulation (specially neutrophils) and collagen deposition in the lungs of ALI mice. The same animals presented with reduced lung and BALF TNF-α and IL-1β expression in comparison with vehicle controls (p<0.05). Additionally, incubation with either EAFPg or kaempferol (100 μg/ml) reduced NO production and cytokine gene expression in cultured LPS-treated RAW 264.7 macrophages. Overall, these results demonstrate that the prophylactic treatment with EAFPg attenuates acute lung inflammation. We suggest this fraction may be useful in treating ALI.http://dx.doi.org/10.1155/2018/6879183 |
| spellingShingle | Aruanã Joaquim Matheus Costa Rodrigues Pinheiro Jaciara Sá Gonçalves Ádylla Wilenna Alves Dourado Eduardo Martins de Sousa Natilene Mesquita Brito Lanna Karinny Silva Marisa Cristina Aranha Batista Joicy Cortez de Sá Cinara Regina Aragão Vieira Monteiro Elizabeth Soares Fernandes Valério Monteiro-Neto Lee Ann Campbell Patrícia Maria Wiziack Zago Lidio Gonçalves Lima-Neto Punica granatum L. Leaf Extract Attenuates Lung Inflammation in Mice with Acute Lung Injury Journal of Immunology Research |
| title | Punica granatum L. Leaf Extract Attenuates Lung Inflammation in Mice with Acute Lung Injury |
| title_full | Punica granatum L. Leaf Extract Attenuates Lung Inflammation in Mice with Acute Lung Injury |
| title_fullStr | Punica granatum L. Leaf Extract Attenuates Lung Inflammation in Mice with Acute Lung Injury |
| title_full_unstemmed | Punica granatum L. Leaf Extract Attenuates Lung Inflammation in Mice with Acute Lung Injury |
| title_short | Punica granatum L. Leaf Extract Attenuates Lung Inflammation in Mice with Acute Lung Injury |
| title_sort | punica granatum l leaf extract attenuates lung inflammation in mice with acute lung injury |
| url | http://dx.doi.org/10.1155/2018/6879183 |
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