Clinical value of inflammatory indices in predicting poor prognosis and post-hemorrhagic hydrocephalus in patients with intraventricular hemorrhage
Abstract Background Hemorrhagic stroke has a high mortality and disability rate. Among them, intraventricular hemorrhage (IVH) is an important factor leading to adverse outcomes. IVH can induce acute obstructive hydrocephalus and chronic communicating hydrocephalus. However, there are currently no e...
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2025-03-01
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| Online Access: | https://doi.org/10.1186/s12883-025-04137-0 |
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| author | Haoxiang Wang Yuanyou Li Feng Ye Ziang Deng Keru Huang Gaowei Li Yaxing Chen Yi Liu Liangxue Zhou |
| author_facet | Haoxiang Wang Yuanyou Li Feng Ye Ziang Deng Keru Huang Gaowei Li Yaxing Chen Yi Liu Liangxue Zhou |
| author_sort | Haoxiang Wang |
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| description | Abstract Background Hemorrhagic stroke has a high mortality and disability rate. Among them, intraventricular hemorrhage (IVH) is an important factor leading to adverse outcomes. IVH can induce acute obstructive hydrocephalus and chronic communicating hydrocephalus. However, there are currently no effective predictive factors for the early prediction of post-hemorrhage hydrocephalus (PHH). Objectives To assess the role of inflammatory indicators in predicting PHH and poor prognostic outcomes in patients with ventricular hemorrhage. Design Single center retrospective case-control study. Methods We retrospectively examined IVH patients treated at our institution from April 2017 to March 2022. Patient characteristics, laboratory data, imaging findings, and 3-month follow-up results were recorded and analyzed. Results Among the 145 patients included in the analysis, 102 eventually developed adverse outcomes. There were significant differences between patients with good and poor prognosis in terms of age at admission, GCS score, prevalence of hypertension, lymphocyte count, albumin level, red blood cell distribution width, neutrophil count, NLR, PLR, NAR, PIV, and SII; in addition, among the 110 surviving patients, 36 eventually developed posthemorrhagic hydrocephalus within 3 months. Multivariate logistic regression showed that age and NAR are independent predictors of poor prognosis in IVH patients, while albumin is an independent predictor of posthemorrhagic hydrocephalus within 3 months. Conclusion The NLR and NAR are independent risk factors for poor prognosis in IVH patients. Additionally, albumin is an independent predictor of chronic hydrocephalus development within 3 months in IVH patients. The NLR, NAR and albumin level could provide prognostic information about IVH patients. |
| format | Article |
| id | doaj-art-c7c377d64fec4069820e152d8dcac24b |
| institution | Kabale University |
| issn | 1471-2377 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
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| series | BMC Neurology |
| spelling | doaj-art-c7c377d64fec4069820e152d8dcac24b2025-08-20T03:41:40ZengBMCBMC Neurology1471-23772025-03-0125111110.1186/s12883-025-04137-0Clinical value of inflammatory indices in predicting poor prognosis and post-hemorrhagic hydrocephalus in patients with intraventricular hemorrhageHaoxiang Wang0Yuanyou Li1Feng Ye2Ziang Deng3Keru Huang4Gaowei Li5Yaxing Chen6Yi Liu7Liangxue Zhou8Department of Neurosurgery, West China Medical School, West China Hospital, Sichuan UniversityDepartment of Pediatric Neurosurgery, West China Second University Hospital, Sichuan UniversityDepartment of Neurosurgery, West China Medical School, West China Hospital, Sichuan UniversityDepartment of Neurosurgery, West China Medical School, West China Hospital, Sichuan UniversityDepartment of Neurosurgery, West China Medical School, West China Hospital, Sichuan UniversityDepartment of Neurosurgery, West China Medical School, West China Hospital, Sichuan UniversityDepartment of Neurosurgery, West China Medical School, West China Hospital, Sichuan UniversityDepartment of Neurosurgery, West China Medical School, West China Hospital, Sichuan UniversityDepartment of Neurosurgery, West China Medical School, West China Hospital, Sichuan UniversityAbstract Background Hemorrhagic stroke has a high mortality and disability rate. Among them, intraventricular hemorrhage (IVH) is an important factor leading to adverse outcomes. IVH can induce acute obstructive hydrocephalus and chronic communicating hydrocephalus. However, there are currently no effective predictive factors for the early prediction of post-hemorrhage hydrocephalus (PHH). Objectives To assess the role of inflammatory indicators in predicting PHH and poor prognostic outcomes in patients with ventricular hemorrhage. Design Single center retrospective case-control study. Methods We retrospectively examined IVH patients treated at our institution from April 2017 to March 2022. Patient characteristics, laboratory data, imaging findings, and 3-month follow-up results were recorded and analyzed. Results Among the 145 patients included in the analysis, 102 eventually developed adverse outcomes. There were significant differences between patients with good and poor prognosis in terms of age at admission, GCS score, prevalence of hypertension, lymphocyte count, albumin level, red blood cell distribution width, neutrophil count, NLR, PLR, NAR, PIV, and SII; in addition, among the 110 surviving patients, 36 eventually developed posthemorrhagic hydrocephalus within 3 months. Multivariate logistic regression showed that age and NAR are independent predictors of poor prognosis in IVH patients, while albumin is an independent predictor of posthemorrhagic hydrocephalus within 3 months. Conclusion The NLR and NAR are independent risk factors for poor prognosis in IVH patients. Additionally, albumin is an independent predictor of chronic hydrocephalus development within 3 months in IVH patients. The NLR, NAR and albumin level could provide prognostic information about IVH patients.https://doi.org/10.1186/s12883-025-04137-0Neutrophil-lymphocyte ratioNeutrophil-albumin ratioIntraventricular hemorrhagePost-hemorrhage hydrocephalusInflammatory markers |
| spellingShingle | Haoxiang Wang Yuanyou Li Feng Ye Ziang Deng Keru Huang Gaowei Li Yaxing Chen Yi Liu Liangxue Zhou Clinical value of inflammatory indices in predicting poor prognosis and post-hemorrhagic hydrocephalus in patients with intraventricular hemorrhage BMC Neurology Neutrophil-lymphocyte ratio Neutrophil-albumin ratio Intraventricular hemorrhage Post-hemorrhage hydrocephalus Inflammatory markers |
| title | Clinical value of inflammatory indices in predicting poor prognosis and post-hemorrhagic hydrocephalus in patients with intraventricular hemorrhage |
| title_full | Clinical value of inflammatory indices in predicting poor prognosis and post-hemorrhagic hydrocephalus in patients with intraventricular hemorrhage |
| title_fullStr | Clinical value of inflammatory indices in predicting poor prognosis and post-hemorrhagic hydrocephalus in patients with intraventricular hemorrhage |
| title_full_unstemmed | Clinical value of inflammatory indices in predicting poor prognosis and post-hemorrhagic hydrocephalus in patients with intraventricular hemorrhage |
| title_short | Clinical value of inflammatory indices in predicting poor prognosis and post-hemorrhagic hydrocephalus in patients with intraventricular hemorrhage |
| title_sort | clinical value of inflammatory indices in predicting poor prognosis and post hemorrhagic hydrocephalus in patients with intraventricular hemorrhage |
| topic | Neutrophil-lymphocyte ratio Neutrophil-albumin ratio Intraventricular hemorrhage Post-hemorrhage hydrocephalus Inflammatory markers |
| url | https://doi.org/10.1186/s12883-025-04137-0 |
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