Combining polyesters of citric and azelaic acids to obtain potential topical application biomaterials with antimicrobial activity
Biomaterials with antimicrobial properties are a key research area due to the increasing threat of infections and the growing resistance of microorganisms to existing antibiotics. The aim of the study was to produce thermally cross-linked polymer films based on poly(1,5-pentanediol azelate) and poly...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1579630/full |
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| author | Aleksandra Bandzerewicz Anna Herman Ewa Dutkowska Klara Niebuda Paweł Ruśkowski Agnieszka Gadomska-Gajadhur |
| author_facet | Aleksandra Bandzerewicz Anna Herman Ewa Dutkowska Klara Niebuda Paweł Ruśkowski Agnieszka Gadomska-Gajadhur |
| author_sort | Aleksandra Bandzerewicz |
| collection | DOAJ |
| description | Biomaterials with antimicrobial properties are a key research area due to the increasing threat of infections and the growing resistance of microorganisms to existing antibiotics. The aim of the study was to produce thermally cross-linked polymer films based on poly(1,5-pentanediol azelate) and poly(1,4-butanediol citrate) with antimicrobial activity for medical applications. Well-formed, cross-linked, flexible materials differing in appearance depending on the conditions of the cross-linking process were obtained. In general, a lower cross-linking temperature was found to promote less brittle and more flexible films with greater structure uniformity. The polymer films had hydrophilic surfaces (water contact angle 40°–60°). All polymer films maintained integrity after immersion in PBS buffer. Most likely, the lower hydrophilicity of the polyazelate phase limited their degradation. A modified time-kill procedure (ASTM E2315-23) was performed to test the antimicrobial properties of the films against Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans. The antimicrobial activity of polycitrate-based films against P. aeruginosa has been reported with >90% reduction of the pathogen after 6 h of contact and 100% biocidal effect after 24 h. The antimicrobial activity of the film is pH-based. The biocidal effect of polycitrate film against P. aeruginosa is the most important and promising result, especially given the resistance of the pathogen to commonly used antibiotics. |
| format | Article |
| id | doaj-art-c7c052ffada04265aba4380a1dbc968d |
| institution | OA Journals |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-c7c052ffada04265aba4380a1dbc968d2025-08-20T02:23:00ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-06-011310.3389/fbioe.2025.15796301579630Combining polyesters of citric and azelaic acids to obtain potential topical application biomaterials with antimicrobial activityAleksandra BandzerewiczAnna HermanEwa DutkowskaKlara NiebudaPaweł RuśkowskiAgnieszka Gadomska-GajadhurBiomaterials with antimicrobial properties are a key research area due to the increasing threat of infections and the growing resistance of microorganisms to existing antibiotics. The aim of the study was to produce thermally cross-linked polymer films based on poly(1,5-pentanediol azelate) and poly(1,4-butanediol citrate) with antimicrobial activity for medical applications. Well-formed, cross-linked, flexible materials differing in appearance depending on the conditions of the cross-linking process were obtained. In general, a lower cross-linking temperature was found to promote less brittle and more flexible films with greater structure uniformity. The polymer films had hydrophilic surfaces (water contact angle 40°–60°). All polymer films maintained integrity after immersion in PBS buffer. Most likely, the lower hydrophilicity of the polyazelate phase limited their degradation. A modified time-kill procedure (ASTM E2315-23) was performed to test the antimicrobial properties of the films against Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans. The antimicrobial activity of polycitrate-based films against P. aeruginosa has been reported with >90% reduction of the pathogen after 6 h of contact and 100% biocidal effect after 24 h. The antimicrobial activity of the film is pH-based. The biocidal effect of polycitrate film against P. aeruginosa is the most important and promising result, especially given the resistance of the pathogen to commonly used antibiotics.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1579630/fullpolycitratepolyazelatepolymer filmswound dressingsPseudomonas aeruginosaantimicrobial |
| spellingShingle | Aleksandra Bandzerewicz Anna Herman Ewa Dutkowska Klara Niebuda Paweł Ruśkowski Agnieszka Gadomska-Gajadhur Combining polyesters of citric and azelaic acids to obtain potential topical application biomaterials with antimicrobial activity Frontiers in Bioengineering and Biotechnology polycitrate polyazelate polymer films wound dressings Pseudomonas aeruginosa antimicrobial |
| title | Combining polyesters of citric and azelaic acids to obtain potential topical application biomaterials with antimicrobial activity |
| title_full | Combining polyesters of citric and azelaic acids to obtain potential topical application biomaterials with antimicrobial activity |
| title_fullStr | Combining polyesters of citric and azelaic acids to obtain potential topical application biomaterials with antimicrobial activity |
| title_full_unstemmed | Combining polyesters of citric and azelaic acids to obtain potential topical application biomaterials with antimicrobial activity |
| title_short | Combining polyesters of citric and azelaic acids to obtain potential topical application biomaterials with antimicrobial activity |
| title_sort | combining polyesters of citric and azelaic acids to obtain potential topical application biomaterials with antimicrobial activity |
| topic | polycitrate polyazelate polymer films wound dressings Pseudomonas aeruginosa antimicrobial |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1579630/full |
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