Combining polyesters of citric and azelaic acids to obtain potential topical application biomaterials with antimicrobial activity
Biomaterials with antimicrobial properties are a key research area due to the increasing threat of infections and the growing resistance of microorganisms to existing antibiotics. The aim of the study was to produce thermally cross-linked polymer films based on poly(1,5-pentanediol azelate) and poly...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1579630/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Biomaterials with antimicrobial properties are a key research area due to the increasing threat of infections and the growing resistance of microorganisms to existing antibiotics. The aim of the study was to produce thermally cross-linked polymer films based on poly(1,5-pentanediol azelate) and poly(1,4-butanediol citrate) with antimicrobial activity for medical applications. Well-formed, cross-linked, flexible materials differing in appearance depending on the conditions of the cross-linking process were obtained. In general, a lower cross-linking temperature was found to promote less brittle and more flexible films with greater structure uniformity. The polymer films had hydrophilic surfaces (water contact angle 40°–60°). All polymer films maintained integrity after immersion in PBS buffer. Most likely, the lower hydrophilicity of the polyazelate phase limited their degradation. A modified time-kill procedure (ASTM E2315-23) was performed to test the antimicrobial properties of the films against Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans. The antimicrobial activity of polycitrate-based films against P. aeruginosa has been reported with >90% reduction of the pathogen after 6 h of contact and 100% biocidal effect after 24 h. The antimicrobial activity of the film is pH-based. The biocidal effect of polycitrate film against P. aeruginosa is the most important and promising result, especially given the resistance of the pathogen to commonly used antibiotics. |
|---|---|
| ISSN: | 2296-4185 |