Identification of Reliable Target Brain Regions for Enhancing Object–Location Memory by Brain Stimulation
ABSTRACT Introduction Object–location memory (OLM) is essential for remembering the locations of objects within an environment and is often impaired in aging and neurodegenerative diseases. Transcranial direct current stimulation (tDCS) has shown promise for improving OLM, although study outcomes ha...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-07-01
|
| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.70658 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849245490525241344 |
|---|---|
| author | Mohamed Abdelmotaleb Filip Niemann Harun Kocataş Leonardo M. Caisachana Guevara Alireza Shahbabaie Robert Malinowski Steffen Riemann Anna Elisabeth Fromm Dayana Hayek Daria Antonenko Marcus Meinzer Agnes Flöel |
| author_facet | Mohamed Abdelmotaleb Filip Niemann Harun Kocataş Leonardo M. Caisachana Guevara Alireza Shahbabaie Robert Malinowski Steffen Riemann Anna Elisabeth Fromm Dayana Hayek Daria Antonenko Marcus Meinzer Agnes Flöel |
| author_sort | Mohamed Abdelmotaleb |
| collection | DOAJ |
| description | ABSTRACT Introduction Object–location memory (OLM) is essential for remembering the locations of objects within an environment and is often impaired in aging and neurodegenerative diseases. Transcranial direct current stimulation (tDCS) has shown promise for improving OLM, although study outcomes have varied considerably. This study aimed to identify key brain regions involved in OLM that may serve as stimulation targets for future tDCS research and to assess the test–retest reliability (TRR) of both behavioral and functional magnetic resonance imaging (fMRI) data. Methods Twenty healthy young adults (10 females; mean age = 25.0 years, standard deviation [SD] = 5.56) completed two task‐based fMRI sessions using parallel versions of an OLM task. Participants learned associations between house images and their locations on a two‐dimensional street map across four feedback‐based learning stages. Sham tDCS was administered in both sessions using a focal 3 × 1 electrode montage. TRR was assessed using intraclass correlation coefficients (ICCs) for behavioral performance and task‐related fMRI activation. Results Behavioral data showed significant improvements in response accuracy (estimate = 0.211, p < 0.001) and a reduction in response latency (estimate = −0.050, p < 0.001) across learning stages. fMRI analysis revealed predominantly right‐lateralized activation, including the right hippocampus, the fusiform gyrus, the precuneus, and the lateral temporo‐occipital areas. Behavioral measures showed moderate to good TRR (accuracy ICC = 0.801; reaction time ICC = 0.705). Task‐related fMRI activity demonstrated good‐to‐excellent TRR in key regions, including the fusiform and temporo‐occipital cortices. Conclusion These findings support the validity of our OLM paradigm for assessing brain stimulation effects and highlight potential cortical targets for future tDCS interventions. The observed reliability of behavioral and neural measures further reinforces the utility of this protocol in crossover study designs. |
| format | Article |
| id | doaj-art-c7bce1a5e21644888a8e8041138b2ffa |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-c7bce1a5e21644888a8e8041138b2ffa2025-08-20T03:58:48ZengWileyBrain and Behavior2162-32792025-07-01157n/an/a10.1002/brb3.70658Identification of Reliable Target Brain Regions for Enhancing Object–Location Memory by Brain StimulationMohamed Abdelmotaleb0Filip Niemann1Harun Kocataş2Leonardo M. Caisachana Guevara3Alireza Shahbabaie4Robert Malinowski5Steffen Riemann6Anna Elisabeth Fromm7Dayana Hayek8Daria Antonenko9Marcus Meinzer10Agnes Flöel11Department of Neurology University Medicine Greifswald Greifswald GermanyDepartment of Neurology University Medicine Greifswald Greifswald GermanyDepartment of Neurology University Medicine Greifswald Greifswald GermanyDepartment of Psychology Greifswald University Greifswald GermanyDepartment of Neurology University Medicine Greifswald Greifswald GermanyDepartment of Neurology University Medicine Greifswald Greifswald GermanyDepartment of Neurology University Medicine Greifswald Greifswald GermanyDepartment of Neurology University Medicine Greifswald Greifswald GermanyDepartment of Neurology University Medicine Greifswald Greifswald GermanyDepartment of Neurology University Medicine Greifswald Greifswald GermanyDepartment of Neurology University Medicine Greifswald Greifswald GermanyDepartment of Neurology University Medicine Greifswald Greifswald GermanyABSTRACT Introduction Object–location memory (OLM) is essential for remembering the locations of objects within an environment and is often impaired in aging and neurodegenerative diseases. Transcranial direct current stimulation (tDCS) has shown promise for improving OLM, although study outcomes have varied considerably. This study aimed to identify key brain regions involved in OLM that may serve as stimulation targets for future tDCS research and to assess the test–retest reliability (TRR) of both behavioral and functional magnetic resonance imaging (fMRI) data. Methods Twenty healthy young adults (10 females; mean age = 25.0 years, standard deviation [SD] = 5.56) completed two task‐based fMRI sessions using parallel versions of an OLM task. Participants learned associations between house images and their locations on a two‐dimensional street map across four feedback‐based learning stages. Sham tDCS was administered in both sessions using a focal 3 × 1 electrode montage. TRR was assessed using intraclass correlation coefficients (ICCs) for behavioral performance and task‐related fMRI activation. Results Behavioral data showed significant improvements in response accuracy (estimate = 0.211, p < 0.001) and a reduction in response latency (estimate = −0.050, p < 0.001) across learning stages. fMRI analysis revealed predominantly right‐lateralized activation, including the right hippocampus, the fusiform gyrus, the precuneus, and the lateral temporo‐occipital areas. Behavioral measures showed moderate to good TRR (accuracy ICC = 0.801; reaction time ICC = 0.705). Task‐related fMRI activity demonstrated good‐to‐excellent TRR in key regions, including the fusiform and temporo‐occipital cortices. Conclusion These findings support the validity of our OLM paradigm for assessing brain stimulation effects and highlight potential cortical targets for future tDCS interventions. The observed reliability of behavioral and neural measures further reinforces the utility of this protocol in crossover study designs.https://doi.org/10.1002/brb3.70658object–location memory (OLM)test–retest reliability (TRR)transcranial direct current stimulation (tDCS)functional magnetic resonance imaging (fMRI) |
| spellingShingle | Mohamed Abdelmotaleb Filip Niemann Harun Kocataş Leonardo M. Caisachana Guevara Alireza Shahbabaie Robert Malinowski Steffen Riemann Anna Elisabeth Fromm Dayana Hayek Daria Antonenko Marcus Meinzer Agnes Flöel Identification of Reliable Target Brain Regions for Enhancing Object–Location Memory by Brain Stimulation Brain and Behavior object–location memory (OLM) test–retest reliability (TRR) transcranial direct current stimulation (tDCS) functional magnetic resonance imaging (fMRI) |
| title | Identification of Reliable Target Brain Regions for Enhancing Object–Location Memory by Brain Stimulation |
| title_full | Identification of Reliable Target Brain Regions for Enhancing Object–Location Memory by Brain Stimulation |
| title_fullStr | Identification of Reliable Target Brain Regions for Enhancing Object–Location Memory by Brain Stimulation |
| title_full_unstemmed | Identification of Reliable Target Brain Regions for Enhancing Object–Location Memory by Brain Stimulation |
| title_short | Identification of Reliable Target Brain Regions for Enhancing Object–Location Memory by Brain Stimulation |
| title_sort | identification of reliable target brain regions for enhancing object location memory by brain stimulation |
| topic | object–location memory (OLM) test–retest reliability (TRR) transcranial direct current stimulation (tDCS) functional magnetic resonance imaging (fMRI) |
| url | https://doi.org/10.1002/brb3.70658 |
| work_keys_str_mv | AT mohamedabdelmotaleb identificationofreliabletargetbrainregionsforenhancingobjectlocationmemorybybrainstimulation AT filipniemann identificationofreliabletargetbrainregionsforenhancingobjectlocationmemorybybrainstimulation AT harunkocatas identificationofreliabletargetbrainregionsforenhancingobjectlocationmemorybybrainstimulation AT leonardomcaisachanaguevara identificationofreliabletargetbrainregionsforenhancingobjectlocationmemorybybrainstimulation AT alirezashahbabaie identificationofreliabletargetbrainregionsforenhancingobjectlocationmemorybybrainstimulation AT robertmalinowski identificationofreliabletargetbrainregionsforenhancingobjectlocationmemorybybrainstimulation AT steffenriemann identificationofreliabletargetbrainregionsforenhancingobjectlocationmemorybybrainstimulation AT annaelisabethfromm identificationofreliabletargetbrainregionsforenhancingobjectlocationmemorybybrainstimulation AT dayanahayek identificationofreliabletargetbrainregionsforenhancingobjectlocationmemorybybrainstimulation AT dariaantonenko identificationofreliabletargetbrainregionsforenhancingobjectlocationmemorybybrainstimulation AT marcusmeinzer identificationofreliabletargetbrainregionsforenhancingobjectlocationmemorybybrainstimulation AT agnesfloel identificationofreliabletargetbrainregionsforenhancingobjectlocationmemorybybrainstimulation |