From gut to brain: exploring the impact of microbiota, dysbiosis, and neuroinflammation in neurodegenerative disorders
Abstract Neurodegenerative disorders, a group of diseases such as Alzheimer’s and Parkinson’s diseases, are identified by gradual memory and motor impairment, thus, seriously affecting aging populations. New research brings a paradigm shift in the pathogenesis of these conditions by identifying gut...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-08-01
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| Series: | Future Journal of Pharmaceutical Sciences |
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| Online Access: | https://doi.org/10.1186/s43094-025-00857-9 |
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| author | A. Deevan Paul Harsini Natarajan |
| author_facet | A. Deevan Paul Harsini Natarajan |
| author_sort | A. Deevan Paul |
| collection | DOAJ |
| description | Abstract Neurodegenerative disorders, a group of diseases such as Alzheimer’s and Parkinson’s diseases, are identified by gradual memory and motor impairment, thus, seriously affecting aging populations. New research brings a paradigm shift in the pathogenesis of these conditions by identifying gut microbiota as a fundamental factor owing to dysbiosis through microbiota-induced neuroinflammation. Besides, the gut microbiome, referred to as dysbiosis, is exclusively responsible for activating the immune system thereby causing neuroinflammation, something that leads to breakdown of the blood–brain barrier and accumulation of toxic protein aggregates, such as amyloid-beta and alpha-synuclein. The gut-brain axis stays in the way of the advancement of such diseases, provided it allows for the necessary biochemical and immunity links. Microbial short-chain fatty acids (SCFA) and other metabolic by-products that are produced by these microbes either increase or decrease the stability of the central nervous system, while reduced SCFA production caused by dysbiosis, however, brings about neuroinflammation. From this perspective, the microbiota-gut-brain connection serves as a novel source for innovation in disease cure, including probiotics, prebiotics, dietary modifications, as well as the microbiota fecal transplant, restoring the microbial balance and thus, alleviating the disease progression. This examination establishes the current role of the microbiota in neurodegeneration and potential microbiome-focused treatments for neuroprotection. |
| format | Article |
| id | doaj-art-c7bb3f44298e4bc5924e09dadc50ecbf |
| institution | DOAJ |
| issn | 2314-7253 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj-art-c7bb3f44298e4bc5924e09dadc50ecbf2025-08-20T03:04:26ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72532025-08-0111111910.1186/s43094-025-00857-9From gut to brain: exploring the impact of microbiota, dysbiosis, and neuroinflammation in neurodegenerative disordersA. Deevan Paul0Harsini Natarajan1Sri Ramachandra Institute of Higher Education and Research, Ramachandra Medical CollegeSri Ramachandra Institute of Higher Education and Research, Ramachandra Medical CollegeAbstract Neurodegenerative disorders, a group of diseases such as Alzheimer’s and Parkinson’s diseases, are identified by gradual memory and motor impairment, thus, seriously affecting aging populations. New research brings a paradigm shift in the pathogenesis of these conditions by identifying gut microbiota as a fundamental factor owing to dysbiosis through microbiota-induced neuroinflammation. Besides, the gut microbiome, referred to as dysbiosis, is exclusively responsible for activating the immune system thereby causing neuroinflammation, something that leads to breakdown of the blood–brain barrier and accumulation of toxic protein aggregates, such as amyloid-beta and alpha-synuclein. The gut-brain axis stays in the way of the advancement of such diseases, provided it allows for the necessary biochemical and immunity links. Microbial short-chain fatty acids (SCFA) and other metabolic by-products that are produced by these microbes either increase or decrease the stability of the central nervous system, while reduced SCFA production caused by dysbiosis, however, brings about neuroinflammation. From this perspective, the microbiota-gut-brain connection serves as a novel source for innovation in disease cure, including probiotics, prebiotics, dietary modifications, as well as the microbiota fecal transplant, restoring the microbial balance and thus, alleviating the disease progression. This examination establishes the current role of the microbiota in neurodegeneration and potential microbiome-focused treatments for neuroprotection.https://doi.org/10.1186/s43094-025-00857-9Gut-brain axisMicrobiotaDysbiosisNeuroinflammationNeurodegenerative disordersAlzheimer’s disease |
| spellingShingle | A. Deevan Paul Harsini Natarajan From gut to brain: exploring the impact of microbiota, dysbiosis, and neuroinflammation in neurodegenerative disorders Future Journal of Pharmaceutical Sciences Gut-brain axis Microbiota Dysbiosis Neuroinflammation Neurodegenerative disorders Alzheimer’s disease |
| title | From gut to brain: exploring the impact of microbiota, dysbiosis, and neuroinflammation in neurodegenerative disorders |
| title_full | From gut to brain: exploring the impact of microbiota, dysbiosis, and neuroinflammation in neurodegenerative disorders |
| title_fullStr | From gut to brain: exploring the impact of microbiota, dysbiosis, and neuroinflammation in neurodegenerative disorders |
| title_full_unstemmed | From gut to brain: exploring the impact of microbiota, dysbiosis, and neuroinflammation in neurodegenerative disorders |
| title_short | From gut to brain: exploring the impact of microbiota, dysbiosis, and neuroinflammation in neurodegenerative disorders |
| title_sort | from gut to brain exploring the impact of microbiota dysbiosis and neuroinflammation in neurodegenerative disorders |
| topic | Gut-brain axis Microbiota Dysbiosis Neuroinflammation Neurodegenerative disorders Alzheimer’s disease |
| url | https://doi.org/10.1186/s43094-025-00857-9 |
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