Antibacterial, Cytotoxic Studies and Characterization of Some Newly Synthesized Symmetrical N3,N3′-Bis(disubstituted)isophthalyl-bis(thioureas) and Their Cu(II) and Ni(II) Complexes
A series of some novel N3,N3′-bis(disubstituted)isophthalyl-bis(thioureas) compounds with general formula [C6H4· {CONHCSNHR}2], where R = 2-ClC6H4S (L1), 3,5-(Cl)2C6H3 (L2), 2,4-(Cl)2C6H3 (L3), 2,5-(Cl)2C6H3 (L4), and 2-NH2C6H4 (L5), and their Cu(II) and Ni(II) complexes (C1–C10) have been synthesiz...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/789743 |
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| author | Muhammad Jamil Muhammad Zubair Muhammad Asim Farid Umer Rashid Nasir Rasool Saiful Islam |
| author_facet | Muhammad Jamil Muhammad Zubair Muhammad Asim Farid Umer Rashid Nasir Rasool Saiful Islam |
| author_sort | Muhammad Jamil |
| collection | DOAJ |
| description | A series of some novel N3,N3′-bis(disubstituted)isophthalyl-bis(thioureas) compounds with general formula [C6H4· {CONHCSNHR}2], where R = 2-ClC6H4S (L1), 3,5-(Cl)2C6H3 (L2), 2,4-(Cl)2C6H3 (L3), 2,5-(Cl)2C6H3 (L4), and 2-NH2C6H4 (L5), and their Cu(II) and Ni(II) complexes (C1–C10) have been synthesized. These compounds (L1–L5) and their metal(II) complexes (C1–C10) have been characterized by elemental analysis, infrared spectroscopy, 1H NMR and 13C NMR spectroscopy, magnetic moments, and electronic spectral measurements. The ligands are coordinated to metal atom in a bidentate pattern producing a neutral complex of the type [ML]2. These compounds (L1–L5) and their metal(II) complexes (C1–C10) were also screened for their antibacterial and cytotoxic activities. |
| format | Article |
| id | doaj-art-c7bac16b43254bf2ad0c6b0770a67aa7 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-c7bac16b43254bf2ad0c6b0770a67aa72025-02-03T01:07:25ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/789743789743Antibacterial, Cytotoxic Studies and Characterization of Some Newly Synthesized Symmetrical N3,N3′-Bis(disubstituted)isophthalyl-bis(thioureas) and Their Cu(II) and Ni(II) ComplexesMuhammad Jamil0Muhammad Zubair1Muhammad Asim Farid2Umer Rashid3Nasir Rasool4Saiful Islam5Department of Chemistry, Government College University, Faisalabad 38000, PakistanDepartment of Chemistry, Government College University, Faisalabad 38000, PakistanInstitute of Chemical Sciences, Bahauddin Zakariya University, Multan 60800, PakistanInstitute of Advanced Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Chemistry, Government College University, Faisalabad 38000, PakistanDepartment of Chemistry, Faculty of Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaA series of some novel N3,N3′-bis(disubstituted)isophthalyl-bis(thioureas) compounds with general formula [C6H4· {CONHCSNHR}2], where R = 2-ClC6H4S (L1), 3,5-(Cl)2C6H3 (L2), 2,4-(Cl)2C6H3 (L3), 2,5-(Cl)2C6H3 (L4), and 2-NH2C6H4 (L5), and their Cu(II) and Ni(II) complexes (C1–C10) have been synthesized. These compounds (L1–L5) and their metal(II) complexes (C1–C10) have been characterized by elemental analysis, infrared spectroscopy, 1H NMR and 13C NMR spectroscopy, magnetic moments, and electronic spectral measurements. The ligands are coordinated to metal atom in a bidentate pattern producing a neutral complex of the type [ML]2. These compounds (L1–L5) and their metal(II) complexes (C1–C10) were also screened for their antibacterial and cytotoxic activities.http://dx.doi.org/10.1155/2013/789743 |
| spellingShingle | Muhammad Jamil Muhammad Zubair Muhammad Asim Farid Umer Rashid Nasir Rasool Saiful Islam Antibacterial, Cytotoxic Studies and Characterization of Some Newly Synthesized Symmetrical N3,N3′-Bis(disubstituted)isophthalyl-bis(thioureas) and Their Cu(II) and Ni(II) Complexes Journal of Chemistry |
| title | Antibacterial, Cytotoxic Studies and Characterization of Some Newly Synthesized Symmetrical N3,N3′-Bis(disubstituted)isophthalyl-bis(thioureas) and Their Cu(II) and Ni(II) Complexes |
| title_full | Antibacterial, Cytotoxic Studies and Characterization of Some Newly Synthesized Symmetrical N3,N3′-Bis(disubstituted)isophthalyl-bis(thioureas) and Their Cu(II) and Ni(II) Complexes |
| title_fullStr | Antibacterial, Cytotoxic Studies and Characterization of Some Newly Synthesized Symmetrical N3,N3′-Bis(disubstituted)isophthalyl-bis(thioureas) and Their Cu(II) and Ni(II) Complexes |
| title_full_unstemmed | Antibacterial, Cytotoxic Studies and Characterization of Some Newly Synthesized Symmetrical N3,N3′-Bis(disubstituted)isophthalyl-bis(thioureas) and Their Cu(II) and Ni(II) Complexes |
| title_short | Antibacterial, Cytotoxic Studies and Characterization of Some Newly Synthesized Symmetrical N3,N3′-Bis(disubstituted)isophthalyl-bis(thioureas) and Their Cu(II) and Ni(II) Complexes |
| title_sort | antibacterial cytotoxic studies and characterization of some newly synthesized symmetrical n3 n3 bis disubstituted isophthalyl bis thioureas and their cu ii and ni ii complexes |
| url | http://dx.doi.org/10.1155/2013/789743 |
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