The roles of TRPC6 in renal tubular disorders: a narrative review
The transient receptor potential canonical 6 (TRPC6) channel, a nonselective cation channel that allows the passage of Ca2+, plays an important role in renal diseases. TRPC6 is activated by Ca2+ influx, oxidative stress, and mechanical stress. Studies have shown that in addition to glomerular diseas...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2376929 |
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| author | Aiqin Sheng Fei Liu Qianhui Wang Haidong Fu Jianhua Mao |
| author_facet | Aiqin Sheng Fei Liu Qianhui Wang Haidong Fu Jianhua Mao |
| author_sort | Aiqin Sheng |
| collection | DOAJ |
| description | The transient receptor potential canonical 6 (TRPC6) channel, a nonselective cation channel that allows the passage of Ca2+, plays an important role in renal diseases. TRPC6 is activated by Ca2+ influx, oxidative stress, and mechanical stress. Studies have shown that in addition to glomerular diseases, TRPC6 can contribute to renal tubular disorders, such as acute kidney injury, renal interstitial fibrosis, and renal cell carcinoma (RCC). However, the tubule-specific physiological functions of TRPC6 have not yet been elucidated. Its pathophysiological role in ischemia/reperfusion (I/R) injury is debatable. Thus, TRPC6 may have dual roles in I/R injury. TRPC6 induces renal fibrosis and immune cell infiltration in a unilateral ureteral obstruction (UUO) mouse model. Additionally, TRPC6 overexpression may modify G2 phase transition, thus altering the DNA damage checkpoint, which can cause genomic instability and RCC tumorigenesis and can control the proliferation of RCC cells. This review highlights the importance of TRPC6 in various conditions of the renal tubular system. To better understand certain renal disorders and ultimately identify new therapeutic targets to improve patient care, the pathophysiology of TRPC6 must be clarified. |
| format | Article |
| id | doaj-art-c7b16616dfcf4d9baa62ff649b3be993 |
| institution | OA Journals |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-c7b16616dfcf4d9baa62ff649b3be9932025-08-20T02:29:59ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146210.1080/0886022X.2024.2376929The roles of TRPC6 in renal tubular disorders: a narrative reviewAiqin Sheng0Fei Liu1Qianhui Wang2Haidong Fu3Jianhua Mao4Department of Nephrology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Nephrology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Nephrology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Nephrology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Nephrology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaThe transient receptor potential canonical 6 (TRPC6) channel, a nonselective cation channel that allows the passage of Ca2+, plays an important role in renal diseases. TRPC6 is activated by Ca2+ influx, oxidative stress, and mechanical stress. Studies have shown that in addition to glomerular diseases, TRPC6 can contribute to renal tubular disorders, such as acute kidney injury, renal interstitial fibrosis, and renal cell carcinoma (RCC). However, the tubule-specific physiological functions of TRPC6 have not yet been elucidated. Its pathophysiological role in ischemia/reperfusion (I/R) injury is debatable. Thus, TRPC6 may have dual roles in I/R injury. TRPC6 induces renal fibrosis and immune cell infiltration in a unilateral ureteral obstruction (UUO) mouse model. Additionally, TRPC6 overexpression may modify G2 phase transition, thus altering the DNA damage checkpoint, which can cause genomic instability and RCC tumorigenesis and can control the proliferation of RCC cells. This review highlights the importance of TRPC6 in various conditions of the renal tubular system. To better understand certain renal disorders and ultimately identify new therapeutic targets to improve patient care, the pathophysiology of TRPC6 must be clarified.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2376929Renal tubular systemtransient receptor potential 6renal ischemia/reperfusion injuryrenal interstitial fibrosisrenal cell carcinoma |
| spellingShingle | Aiqin Sheng Fei Liu Qianhui Wang Haidong Fu Jianhua Mao The roles of TRPC6 in renal tubular disorders: a narrative review Renal Failure Renal tubular system transient receptor potential 6 renal ischemia/reperfusion injury renal interstitial fibrosis renal cell carcinoma |
| title | The roles of TRPC6 in renal tubular disorders: a narrative review |
| title_full | The roles of TRPC6 in renal tubular disorders: a narrative review |
| title_fullStr | The roles of TRPC6 in renal tubular disorders: a narrative review |
| title_full_unstemmed | The roles of TRPC6 in renal tubular disorders: a narrative review |
| title_short | The roles of TRPC6 in renal tubular disorders: a narrative review |
| title_sort | roles of trpc6 in renal tubular disorders a narrative review |
| topic | Renal tubular system transient receptor potential 6 renal ischemia/reperfusion injury renal interstitial fibrosis renal cell carcinoma |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2376929 |
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