Metformin reverses 5-FU resistance induced by radiotherapy through mediating folate metabolism in colorectal cancer

Metformin reverses 5-FU resistance induced by radiotherapy through mediating folate metabolism in colorectal cancer

Abstract Purpose Radiation therapy has revolutionized the treatment of primary or liver metastases in colorectal cancer (CRC). In colorectal cancer, conventional fractionation (1.8 ~ 2.0 Gy daily) is typically used for treatment. Nevertheless, there is a paucity of research investigating the potenti...

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Bibliographic Details
Main Authors: Shuxuan Wang, Yanyan Lin, Qianqian Zhao, Huanliang Chen, Shisuo Du, Zhaochong Zeng
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Medicine
Subjects:
Irradiation
5-FU
Histocompatibility minor 13
Metformin
Folate metabolism
Online Access:https://doi.org/10.1186/s10020-025-01206-5
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