Prime editor with rational design and AI-driven optimization for reverse editing window and enhanced fidelity

Prime editor with rational design and AI-driven optimization for reverse editing window and enhanced fidelity

Abstract Prime editing (PE) is a precise tool for introducing genetic mutations in eukaryotes. Extending the efficient editing scope and mitigating undesired byproducts are possible. We introduce reverse PE (rPE), a SpCas9-directed variant that enabled DNA editing at the 3′ direction of HNH-mediated...

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Bibliographic Details
Main Authors: Chao Yang, Qingxiao Fang, Mengyu Li, Jin Zhang, Rui Li, Tianxing Zhou, Keshan Wang, Jie Deng, Xiuchao Wang, Chongbiao Huang, Yukuan Feng, Xiaoping Zhang, Lei Shi, Changhao Bi, Xueli Zhang, Jun Yu, Jihui Hao
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60495-w
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