Porphyromonas gingivalis-induced periodontitis promotes neuroinflammation and neuronal loss associated with dysfunction of the brain barrier

Porphyromonas gingivalis-induced periodontitis promotes neuroinflammation and neuronal loss associated with dysfunction of the brain barrier

BackgroundIn our previous study, Porphyromonas gingivalis (P. gingivalis)-induced periodontitis caused cognitive impairment which was associated with abnormal amyloid β (Aβ) metabolite in the brain. The brain barrier is critical in maintaining homeostasis, controlling influx and efflux transport and...

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Bibliographic Details
Main Authors: Yiting Jiang, Lina Xu, Xuri Zhao, Hui Shen, Che Qiu, Zhiyan He, Zhongchen Song, Wei Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
periodontitis
P. gingivalis
tau hyperphosphorylation
brain barrier
cognitive impairment
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1559182/full
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