Variability of antimicrobial susceptibility of commensal Neisseria species supports its use as a marker of excessive antimicrobial consumption – reflections from the results of a four-country study
This perspective explores the utility of commensal Neisseria species as an early warning sign of excessive antimicrobial consumption. Little is known as to how the prevalence and antimicrobial susceptibility of various commensal Neisseria species varies between populations around the world. We compa...
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Elsevier
2025-05-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971225000931 |
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| author | Izumo Kanesaka Claudio Foschi Antonella Marangoni Paul C Adamson Jeffrey Klausner Huan Vinh Dong Thibaut Vanbaelen Irith De Baetselier Tessa de Block Sheeba Santhini Manoharan-Basil Chris Kenyon |
| author_facet | Izumo Kanesaka Claudio Foschi Antonella Marangoni Paul C Adamson Jeffrey Klausner Huan Vinh Dong Thibaut Vanbaelen Irith De Baetselier Tessa de Block Sheeba Santhini Manoharan-Basil Chris Kenyon |
| author_sort | Izumo Kanesaka |
| collection | DOAJ |
| description | This perspective explores the utility of commensal Neisseria species as an early warning sign of excessive antimicrobial consumption. Little is known as to how the prevalence and antimicrobial susceptibility of various commensal Neisseria species varies between populations around the world. We compared the prevalence and antimicrobial susceptibilities of oral commensal Neisseria species in the general population and cohorts of men who have sex with men (MSM) in four countries with available data – Belgium, Italy, Japan and Vietnam. In individuals where Neisseria spp. were detected, N. subflava was present in 70-100% of individuals in the different studies. The N. subflava azithromycin and ciprofloxacin minimum inhibitory concentrations (MICs) were higher in the MSM than in the general population. The MICs of all Neisseria spp. were very similar in the general populations of Belgium and Italy. For all Neisseria spp., azithromycin and ceftriaxone MICs were higher, whereas ciprofloxacin MICs were lower in Belgium and Italy than in Japan. The higher azithromycin and ciprofloxacin MICs observed in the cohorts of MSM compared to the general population and the higher ciprofloxacin MICs in Japan compared to Belgium and Italy are commensurate with the most commonly antimicrobial prescribed in these populations. Our results support using commensal Neisseria species as an early warning system of excessive antimicrobial consumption. |
| format | Article |
| id | doaj-art-c79f94c63ac941b3bedd8d12a44648cc |
| institution | DOAJ |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj-art-c79f94c63ac941b3bedd8d12a44648cc2025-08-20T03:06:30ZengElsevierInternational Journal of Infectious Diseases1201-97122025-05-0115410787010.1016/j.ijid.2025.107870Variability of antimicrobial susceptibility of commensal Neisseria species supports its use as a marker of excessive antimicrobial consumption – reflections from the results of a four-country studyIzumo Kanesaka0Claudio Foschi1Antonella Marangoni2Paul C Adamson3Jeffrey Klausner4Huan Vinh Dong5Thibaut Vanbaelen6Irith De Baetselier7Tessa de Block8Sheeba Santhini Manoharan-Basil9Chris Kenyon10Department of Clinical Sciences, Institute of Tropical Medicine Antwerp, Antwerp, Belgium; Department of Infection Control and Prevention, Faculty of Nursing, Toho University, JapanDepartment of Medical and Surgical Sciences, Section of Microbiology, Alma Mater Studiorum - University of Bologna, Bologna, Italy; Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDepartment of Medical and Surgical Sciences, Section of Microbiology, Alma Mater Studiorum - University of Bologna, Bologna, ItalyDivision of Infectious Diseases, David Geffen School of Medicine, University of California, Los AngelesDepartment of Medicine and Population & Public Health Sciences, University of Southern CaliforniaDepartment of Pediatric Infectious Diseases, University of California, Los Angeles, USADepartment of Clinical Sciences, Institute of Tropical Medicine Antwerp, Antwerp, BelgiumDepartment of Clinical Sciences, Institute of Tropical Medicine Antwerp, Antwerp, BelgiumDepartment of Clinical Sciences, Institute of Tropical Medicine Antwerp, Antwerp, BelgiumDepartment of Clinical Sciences, Institute of Tropical Medicine Antwerp, Antwerp, BelgiumDepartment of Clinical Sciences, Institute of Tropical Medicine Antwerp, Antwerp, Belgium; Department of Medicine, University of Cape Town, Cape Town, South Africa; Corresponding author at: Nationalestraat 155, Antwerp, 2000 BelgiumThis perspective explores the utility of commensal Neisseria species as an early warning sign of excessive antimicrobial consumption. Little is known as to how the prevalence and antimicrobial susceptibility of various commensal Neisseria species varies between populations around the world. We compared the prevalence and antimicrobial susceptibilities of oral commensal Neisseria species in the general population and cohorts of men who have sex with men (MSM) in four countries with available data – Belgium, Italy, Japan and Vietnam. In individuals where Neisseria spp. were detected, N. subflava was present in 70-100% of individuals in the different studies. The N. subflava azithromycin and ciprofloxacin minimum inhibitory concentrations (MICs) were higher in the MSM than in the general population. The MICs of all Neisseria spp. were very similar in the general populations of Belgium and Italy. For all Neisseria spp., azithromycin and ceftriaxone MICs were higher, whereas ciprofloxacin MICs were lower in Belgium and Italy than in Japan. The higher azithromycin and ciprofloxacin MICs observed in the cohorts of MSM compared to the general population and the higher ciprofloxacin MICs in Japan compared to Belgium and Italy are commensurate with the most commonly antimicrobial prescribed in these populations. Our results support using commensal Neisseria species as an early warning system of excessive antimicrobial consumption.http://www.sciencedirect.com/science/article/pii/S1201971225000931NeisseriaCommensalsOropharynxAntimicrobial resistanceBelgiumItaly |
| spellingShingle | Izumo Kanesaka Claudio Foschi Antonella Marangoni Paul C Adamson Jeffrey Klausner Huan Vinh Dong Thibaut Vanbaelen Irith De Baetselier Tessa de Block Sheeba Santhini Manoharan-Basil Chris Kenyon Variability of antimicrobial susceptibility of commensal Neisseria species supports its use as a marker of excessive antimicrobial consumption – reflections from the results of a four-country study International Journal of Infectious Diseases Neisseria Commensals Oropharynx Antimicrobial resistance Belgium Italy |
| title | Variability of antimicrobial susceptibility of commensal Neisseria species supports its use as a marker of excessive antimicrobial consumption – reflections from the results of a four-country study |
| title_full | Variability of antimicrobial susceptibility of commensal Neisseria species supports its use as a marker of excessive antimicrobial consumption – reflections from the results of a four-country study |
| title_fullStr | Variability of antimicrobial susceptibility of commensal Neisseria species supports its use as a marker of excessive antimicrobial consumption – reflections from the results of a four-country study |
| title_full_unstemmed | Variability of antimicrobial susceptibility of commensal Neisseria species supports its use as a marker of excessive antimicrobial consumption – reflections from the results of a four-country study |
| title_short | Variability of antimicrobial susceptibility of commensal Neisseria species supports its use as a marker of excessive antimicrobial consumption – reflections from the results of a four-country study |
| title_sort | variability of antimicrobial susceptibility of commensal neisseria species supports its use as a marker of excessive antimicrobial consumption reflections from the results of a four country study |
| topic | Neisseria Commensals Oropharynx Antimicrobial resistance Belgium Italy |
| url | http://www.sciencedirect.com/science/article/pii/S1201971225000931 |
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