Aberrant METTL1-mediated tRNA m7G modification alters B-cell responses in systemic autoimmunity in humans and mice

Aberrant METTL1-mediated tRNA m7G modification alters B-cell responses in systemic autoimmunity in humans and mice

Abstract Upon activation, naive B cells exit their quiescent state and enter germinal center (GC) responses, a transition accompanied by increased protein synthesis. How protein translation efficiency is adequately adjusted to meet the increased demand requires further investigation. Here, we identi...

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Main Authors: Shuyi Wang, Hui Han, Yichao Qian, Xinyuan Ruan, Zhangmei Lin, Jin Li, Binfeng Chen, Yimei Lai, Zhaoyu Wang, Mengyuan Li, Jingping Wen, Xiaoyu Yin, Niansheng Yang, Shuibin Lin, Hui Zhang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54941-4
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