Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids
Filoviruses, mainly consisting of the two genera of <i>Ebolavirus</i> and <i>Marburgvirus</i>, are enveloped negative-strand RNA viruses that can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates. However, we still do not have effective...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/23/1/23 |
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| author | Leah Liu Wang Javier Seravalli Brett Eaton Yi Liu Michael R. Holbrook Wen-Jian Lan Shi-Hua Xiang |
| author_facet | Leah Liu Wang Javier Seravalli Brett Eaton Yi Liu Michael R. Holbrook Wen-Jian Lan Shi-Hua Xiang |
| author_sort | Leah Liu Wang |
| collection | DOAJ |
| description | Filoviruses, mainly consisting of the two genera of <i>Ebolavirus</i> and <i>Marburgvirus</i>, are enveloped negative-strand RNA viruses that can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates. However, we still do not have effective medicines for treating these diseases. To search for effective drugs, we have identified three marine indole alkaloids that exhibit potent activities against filovirus infection. Thus, it is suggested that marine indole alkaloids can be a valuable compound source for filovirus drug screening and development. Since marine indole alkaloids comprise a large diverse group of secondary metabolites, their biological properties would be helpful for pharmaceutical drug development to treat various filovirus infections. |
| format | Article |
| id | doaj-art-c79cb1937afd4008b1f3abeb4dfeb50d |
| institution | Kabale University |
| issn | 1660-3397 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-c79cb1937afd4008b1f3abeb4dfeb50d2025-01-24T13:39:30ZengMDPI AGMarine Drugs1660-33972025-01-012312310.3390/md23010023Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole AlkaloidsLeah Liu Wang0Javier Seravalli1Brett Eaton2Yi Liu3Michael R. Holbrook4Wen-Jian Lan5Shi-Hua Xiang6Nebraska Center for Virology, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USADepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USAIntegrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, Frederick, MD 21702, USAHolland Computing Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USAIntegrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, Frederick, MD 21702, USASchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaNebraska Center for Virology, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USAFiloviruses, mainly consisting of the two genera of <i>Ebolavirus</i> and <i>Marburgvirus</i>, are enveloped negative-strand RNA viruses that can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates. However, we still do not have effective medicines for treating these diseases. To search for effective drugs, we have identified three marine indole alkaloids that exhibit potent activities against filovirus infection. Thus, it is suggested that marine indole alkaloids can be a valuable compound source for filovirus drug screening and development. Since marine indole alkaloids comprise a large diverse group of secondary metabolites, their biological properties would be helpful for pharmaceutical drug development to treat various filovirus infections.https://www.mdpi.com/1660-3397/23/1/23indole alkaloidsfilovirusentry inhibitorsmarine fungus<i>Fusarium</i> sp.secondary metabolites |
| spellingShingle | Leah Liu Wang Javier Seravalli Brett Eaton Yi Liu Michael R. Holbrook Wen-Jian Lan Shi-Hua Xiang Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids Marine Drugs indole alkaloids filovirus entry inhibitors marine fungus <i>Fusarium</i> sp. secondary metabolites |
| title | Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids |
| title_full | Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids |
| title_fullStr | Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids |
| title_full_unstemmed | Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids |
| title_short | Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids |
| title_sort | identification of filovirus entry inhibitors from marine fungus derived indole alkaloids |
| topic | indole alkaloids filovirus entry inhibitors marine fungus <i>Fusarium</i> sp. secondary metabolites |
| url | https://www.mdpi.com/1660-3397/23/1/23 |
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