The Genetics of Parkinson’s Disease
Parkinson's disease (PD) is one of the most common neurodegenerative diseases worldwide. Approximately 15% of PD patients have a family history of the disease in one or more first-degree relatives, and 5-10% of PD cases exhibit a classical Mendelian inheritance pattern. In 1997, the heritable t...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2024-02-01
|
| Series: | Genel Tıp Dergisi |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/3307075 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841562271207129088 |
|---|---|
| author | Levent Şimşek Emine Berrin Yüksel Zeliha Yücel |
| author_facet | Levent Şimşek Emine Berrin Yüksel Zeliha Yücel |
| author_sort | Levent Şimşek |
| collection | DOAJ |
| description | Parkinson's disease (PD) is one of the most common neurodegenerative diseases worldwide. Approximately 15% of PD patients have a family history of the disease in one or more first-degree relatives, and 5-10% of PD cases exhibit a classical Mendelian inheritance pattern. In 1997, the heritable transmission of PD was first documented. Recent studies have found 90 independent genome-wide signals at 78 loci that may be associated with PD. The identification of genes linked to PD and their functions has uncovered novel biological pathways and treatment options that play a role in the development of PD. In this article, it is aimed to review up-to-date information on the genetics of PD. |
| format | Article |
| id | doaj-art-c798d66b5b574be383309e2bb9665881 |
| institution | Kabale University |
| issn | 2602-3741 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Genel Tıp Dergisi |
| spelling | doaj-art-c798d66b5b574be383309e2bb96658812025-01-03T01:05:26ZengSelcuk University PressGenel Tıp Dergisi2602-37412024-02-0134113614310.54005/geneltip.1337447154The Genetics of Parkinson’s DiseaseLevent Şimşek0Emine Berrin Yüksel1Zeliha Yücel2KONYA ŞEHİR HASTANESİ, TIBBİ GENETİK BİRİMİKARAMANOĞLU MEHMETBEY ÜNİVERSİTESİ,TIP FAKÜLTESİ,TIBBİ GENETİK ANA BİLİM DALIKARAMAN EĞİTİM VE ARAŞTIRMA HASTANESİParkinson's disease (PD) is one of the most common neurodegenerative diseases worldwide. Approximately 15% of PD patients have a family history of the disease in one or more first-degree relatives, and 5-10% of PD cases exhibit a classical Mendelian inheritance pattern. In 1997, the heritable transmission of PD was first documented. Recent studies have found 90 independent genome-wide signals at 78 loci that may be associated with PD. The identification of genes linked to PD and their functions has uncovered novel biological pathways and treatment options that play a role in the development of PD. In this article, it is aimed to review up-to-date information on the genetics of PD.https://dergipark.org.tr/tr/download/article-file/3307075parkinson’s diseaseinheritanceautosomal dominantautosomal recessiveparkinson hastalığıkalıtımotozomal dominantotozomal resesif |
| spellingShingle | Levent Şimşek Emine Berrin Yüksel Zeliha Yücel The Genetics of Parkinson’s Disease Genel Tıp Dergisi parkinson’s disease inheritance autosomal dominant autosomal recessive parkinson hastalığı kalıtım otozomal dominant otozomal resesif |
| title | The Genetics of Parkinson’s Disease |
| title_full | The Genetics of Parkinson’s Disease |
| title_fullStr | The Genetics of Parkinson’s Disease |
| title_full_unstemmed | The Genetics of Parkinson’s Disease |
| title_short | The Genetics of Parkinson’s Disease |
| title_sort | genetics of parkinson s disease |
| topic | parkinson’s disease inheritance autosomal dominant autosomal recessive parkinson hastalığı kalıtım otozomal dominant otozomal resesif |
| url | https://dergipark.org.tr/tr/download/article-file/3307075 |
| work_keys_str_mv | AT leventsimsek thegeneticsofparkinsonsdisease AT emineberrinyuksel thegeneticsofparkinsonsdisease AT zelihayucel thegeneticsofparkinsonsdisease AT leventsimsek geneticsofparkinsonsdisease AT emineberrinyuksel geneticsofparkinsonsdisease AT zelihayucel geneticsofparkinsonsdisease |