Soluble human macrophage factors are able to inhibit TGF-β-induced differentiation of lung fibroblasts

Soluble human macrophage factors are able to inhibit TGF-β-induced differentiation of lung fibroblasts

Macrophages are key regulatory cells of fibrogenesis. They can have pro- or antifibrotic activity due to their plasticity and heterogeneity. Some studies have shown the antifibrotic effect of macrophages on dermal fibroblasts, but the effect of macrophages on the lung fibroblast functions remains un...

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Bibliographic Details
Main Authors: A. A. Maksimova, E. Ya. Shevela, L. V. Sakhno
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2024-07-01
Series:Медицинская иммунология
Subjects:
macrophages
fibroblasts
conditioned media
antifibrotic activity
collagen
α-smooth actin
Online Access:https://www.mimmun.ru/mimmun/article/view/3029
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