“The effect of intramuscular dexmedetomidine versus oral gabapentin premedication on the emergence agitation after rhinoplasty”. A prospective, randomized, double-blind controlled trial
Abstract Background Emergence agitation EA is a state of confusion and harmful aggressiveness during recovery. It is a common complication after rhinoplasty, with risk of trauma, bleeding, and hemodynamic instability. Dexmedetomidine and gabapentin premedication could improve the quality of recovery...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12871-025-02914-5 |
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| author | Tamer Samir Abdelsalam Abdelaziz Hatem Elsayed Mohammed Elsayed Doaa Mohammed Kamal Eldin Ismail Mohammed Ibrahim |
| author_facet | Tamer Samir Abdelsalam Abdelaziz Hatem Elsayed Mohammed Elsayed Doaa Mohammed Kamal Eldin Ismail Mohammed Ibrahim |
| author_sort | Tamer Samir Abdelsalam Abdelaziz |
| collection | DOAJ |
| description | Abstract Background Emergence agitation EA is a state of confusion and harmful aggressiveness during recovery. It is a common complication after rhinoplasty, with risk of trauma, bleeding, and hemodynamic instability. Dexmedetomidine and gabapentin premedication could improve the quality of recovery after rhinoplasty. Methods One hundred fifty-three participants (ASA I-II, both sexes and age 18–40 years) scheduled for rhinoplasty were randomized into three groups. Group C didn’t receive premedication, Group D received intramuscular (IM) dexmedetomidine, and Group G received oral gabapentin. The degree of EA by Riker sedation-agitation scale (RSAS) during recovery, pain severity, and adverse events recorded. Results The results showed statistically significant differences in EA scores with the lowest values in group D (p-value 0.002). Moreover, the incidence of EA was 17.6% (9/51) in Group D, 41.2% (21/51) in Group G, and 56.9% (29/51) in Group C with P value < 0.001 and significant differences in VAS score at 4, 8, and 12 h with the highest median (range) values in group C 4(3–6) in comparison to group D 2(1–3) and group G 2(1–3) and p-value < 0.001; no significant differences in adverse events. Conclusions IM dexmedetomidine premedication was more efficient than gabapentin in the reduction of the emergence agitation incidence, severity, and postoperative pain scores after rhinoplasty in adults. Clinical trial registration number ID NCT05626998 on 25/11/2022. |
| format | Article |
| id | doaj-art-c7955ad84133464e8588f02786da7efd |
| institution | Kabale University |
| issn | 1471-2253 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj-art-c7955ad84133464e8588f02786da7efd2025-02-02T12:40:03ZengBMCBMC Anesthesiology1471-22532025-01-012511610.1186/s12871-025-02914-5“The effect of intramuscular dexmedetomidine versus oral gabapentin premedication on the emergence agitation after rhinoplasty”. A prospective, randomized, double-blind controlled trialTamer Samir Abdelsalam Abdelaziz0Hatem Elsayed Mohammed Elsayed1Doaa Mohammed Kamal Eldin2Ismail Mohammed Ibrahim3 Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams UniversityAbstract Background Emergence agitation EA is a state of confusion and harmful aggressiveness during recovery. It is a common complication after rhinoplasty, with risk of trauma, bleeding, and hemodynamic instability. Dexmedetomidine and gabapentin premedication could improve the quality of recovery after rhinoplasty. Methods One hundred fifty-three participants (ASA I-II, both sexes and age 18–40 years) scheduled for rhinoplasty were randomized into three groups. Group C didn’t receive premedication, Group D received intramuscular (IM) dexmedetomidine, and Group G received oral gabapentin. The degree of EA by Riker sedation-agitation scale (RSAS) during recovery, pain severity, and adverse events recorded. Results The results showed statistically significant differences in EA scores with the lowest values in group D (p-value 0.002). Moreover, the incidence of EA was 17.6% (9/51) in Group D, 41.2% (21/51) in Group G, and 56.9% (29/51) in Group C with P value < 0.001 and significant differences in VAS score at 4, 8, and 12 h with the highest median (range) values in group C 4(3–6) in comparison to group D 2(1–3) and group G 2(1–3) and p-value < 0.001; no significant differences in adverse events. Conclusions IM dexmedetomidine premedication was more efficient than gabapentin in the reduction of the emergence agitation incidence, severity, and postoperative pain scores after rhinoplasty in adults. Clinical trial registration number ID NCT05626998 on 25/11/2022.https://doi.org/10.1186/s12871-025-02914-5DexmedetomidineEmergence agitationGabapentinGeneral anesthesiaPostoperative painRhinoplasty |
| spellingShingle | Tamer Samir Abdelsalam Abdelaziz Hatem Elsayed Mohammed Elsayed Doaa Mohammed Kamal Eldin Ismail Mohammed Ibrahim “The effect of intramuscular dexmedetomidine versus oral gabapentin premedication on the emergence agitation after rhinoplasty”. A prospective, randomized, double-blind controlled trial BMC Anesthesiology Dexmedetomidine Emergence agitation Gabapentin General anesthesia Postoperative pain Rhinoplasty |
| title | “The effect of intramuscular dexmedetomidine versus oral gabapentin premedication on the emergence agitation after rhinoplasty”. A prospective, randomized, double-blind controlled trial |
| title_full | “The effect of intramuscular dexmedetomidine versus oral gabapentin premedication on the emergence agitation after rhinoplasty”. A prospective, randomized, double-blind controlled trial |
| title_fullStr | “The effect of intramuscular dexmedetomidine versus oral gabapentin premedication on the emergence agitation after rhinoplasty”. A prospective, randomized, double-blind controlled trial |
| title_full_unstemmed | “The effect of intramuscular dexmedetomidine versus oral gabapentin premedication on the emergence agitation after rhinoplasty”. A prospective, randomized, double-blind controlled trial |
| title_short | “The effect of intramuscular dexmedetomidine versus oral gabapentin premedication on the emergence agitation after rhinoplasty”. A prospective, randomized, double-blind controlled trial |
| title_sort | the effect of intramuscular dexmedetomidine versus oral gabapentin premedication on the emergence agitation after rhinoplasty a prospective randomized double blind controlled trial |
| topic | Dexmedetomidine Emergence agitation Gabapentin General anesthesia Postoperative pain Rhinoplasty |
| url | https://doi.org/10.1186/s12871-025-02914-5 |
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