Microwave Synthesis and Antimicrobial Evaluation of Selected Aminophosphonates
In the search for new bioactive molecules, a series of new molecules from the phosphonate family were synthesized via the Kabachnik–Fields reaction (phosphonate ester) and the Irani–Moedritzer reaction (phosphonic acids). Their structures were characterized by various spectroscopic methods, includin...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
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| Series: | Chemistry Proceedings |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4583/16/1/50 |
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| Summary: | In the search for new bioactive molecules, a series of new molecules from the phosphonate family were synthesized via the Kabachnik–Fields reaction (phosphonate ester) and the Irani–Moedritzer reaction (phosphonic acids). Their structures were characterized by various spectroscopic methods, including IR and UV-vis. The synthesized compounds were screened for in vitro antimicrobial activity against Gram-positive (<i>Bacillus subtilis</i> and <i>Staphylococcus aureus</i>) and Gram-negative (<i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i>) bacteria, using the well method. The results also showed that all the products synthesized exhibited good activity with a zone of inhibition: D > 8, except one product against <i>S. aureus</i> bacteria. The three products were tested for their antifungal effects against three pathogenic fungal strains, namely <i>Candida albicans</i>, <i>Aspergillus niger</i>, and <i>Penicillium notatum</i>. The results show that the zones of maximum inhibition were observed against <i>P. notatum</i> (35.5 mm). Therefore, the biological tests showed that all the compounds studied exhibited high antibacterial and antifungal activities. |
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| ISSN: | 2673-4583 |