Identification and mitigation of blood's interference with the antimicrobial activity of AgNbO3 particles.
The detrimental impact of blood on the antimicrobial activity of AgNbO3 particles was identified and investigated. It was observed that the impact is more severe in the case of lysed blood. The same phenomenon also operates in the case of commonly used silver salt, AgNO3. The inhibition was shown to...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0313055 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849424061650698240 |
|---|---|
| author | Cyrus Talebpour Fereshteh Fani Marc Ouellette Marilynn Fairfax Houshang Alamdari Hossein Salimnia |
| author_facet | Cyrus Talebpour Fereshteh Fani Marc Ouellette Marilynn Fairfax Houshang Alamdari Hossein Salimnia |
| author_sort | Cyrus Talebpour |
| collection | DOAJ |
| description | The detrimental impact of blood on the antimicrobial activity of AgNbO3 particles was identified and investigated. It was observed that the impact is more severe in the case of lysed blood. The same phenomenon also operates in the case of commonly used silver salt, AgNO3. The inhibition was shown to be due to hemoglobin, but may be unrelated to the heme moiety. In an attempt to find additives to mitigate the inhibitory effect of hemoglobin, iron ions and the chelating agent, K2EDTA, were initially considered as potential candidates. Including ferric iron on the particles was shown to have a marginal effect, but supplying the medium with K2EDTA chelating agent, provided a better outcome for countering the deleterious impact of hemoglobin on AgNbO3 activity. These findings may be relevant for adapting the silver compounds to applications such as wound dressings, where silver's antimicrobial action would have to take place in a blood containing environment. |
| format | Article |
| id | doaj-art-c78750cc0a7c495fb54cc8ce4905ffa3 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-c78750cc0a7c495fb54cc8ce4905ffa32025-08-20T03:30:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01206e031305510.1371/journal.pone.0313055Identification and mitigation of blood's interference with the antimicrobial activity of AgNbO3 particles.Cyrus TalebpourFereshteh FaniMarc OuelletteMarilynn FairfaxHoushang AlamdariHossein SalimniaThe detrimental impact of blood on the antimicrobial activity of AgNbO3 particles was identified and investigated. It was observed that the impact is more severe in the case of lysed blood. The same phenomenon also operates in the case of commonly used silver salt, AgNO3. The inhibition was shown to be due to hemoglobin, but may be unrelated to the heme moiety. In an attempt to find additives to mitigate the inhibitory effect of hemoglobin, iron ions and the chelating agent, K2EDTA, were initially considered as potential candidates. Including ferric iron on the particles was shown to have a marginal effect, but supplying the medium with K2EDTA chelating agent, provided a better outcome for countering the deleterious impact of hemoglobin on AgNbO3 activity. These findings may be relevant for adapting the silver compounds to applications such as wound dressings, where silver's antimicrobial action would have to take place in a blood containing environment.https://doi.org/10.1371/journal.pone.0313055 |
| spellingShingle | Cyrus Talebpour Fereshteh Fani Marc Ouellette Marilynn Fairfax Houshang Alamdari Hossein Salimnia Identification and mitigation of blood's interference with the antimicrobial activity of AgNbO3 particles. PLoS ONE |
| title | Identification and mitigation of blood's interference with the antimicrobial activity of AgNbO3 particles. |
| title_full | Identification and mitigation of blood's interference with the antimicrobial activity of AgNbO3 particles. |
| title_fullStr | Identification and mitigation of blood's interference with the antimicrobial activity of AgNbO3 particles. |
| title_full_unstemmed | Identification and mitigation of blood's interference with the antimicrobial activity of AgNbO3 particles. |
| title_short | Identification and mitigation of blood's interference with the antimicrobial activity of AgNbO3 particles. |
| title_sort | identification and mitigation of blood s interference with the antimicrobial activity of agnbo3 particles |
| url | https://doi.org/10.1371/journal.pone.0313055 |
| work_keys_str_mv | AT cyrustalebpour identificationandmitigationofbloodsinterferencewiththeantimicrobialactivityofagnbo3particles AT fereshtehfani identificationandmitigationofbloodsinterferencewiththeantimicrobialactivityofagnbo3particles AT marcouellette identificationandmitigationofbloodsinterferencewiththeantimicrobialactivityofagnbo3particles AT marilynnfairfax identificationandmitigationofbloodsinterferencewiththeantimicrobialactivityofagnbo3particles AT houshangalamdari identificationandmitigationofbloodsinterferencewiththeantimicrobialactivityofagnbo3particles AT hosseinsalimnia identificationandmitigationofbloodsinterferencewiththeantimicrobialactivityofagnbo3particles |