Hepatocyte Rho-associated kinase signaling is required for mice to survive experimental porphyria-associated liver injury

Hepatocyte Rho-associated kinase signaling is required for mice to survive experimental porphyria-associated liver injury

Background:. Rho-associated kinases 1 and 2 (ROCK1 and ROCK2) regulate critical cell functions, including actomyosin contractility, apoptosis, and proliferation. Some studies suggest that ROCK inhibition may serve as a treatment for liver fibrosis. More investigation is needed to understand the role...

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Bibliographic Details
Main Authors: Jessica M. Herrera, Yun Weng, Tyler J. Lieberthal, Marcus Paoletti, Tammy T. Chang
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2025-02-01
Series:Hepatology Communications
Online Access:http://journals.lww.com/10.1097/HC9.0000000000000636
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