Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney
In the past few years the understanding of the renin-angiotensin system (RAS) has improved, helping to better define the role of this system in physiological conditions and in human diseases. Besides Angiotensin (Ang) II, the biological importance of other Ang fragments was progressively evidenced....
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/414128 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549747953500160 |
|---|---|
| author | Sergio Veloso Brant Pinheiro Ana Cristina Simões e Silva |
| author_facet | Sergio Veloso Brant Pinheiro Ana Cristina Simões e Silva |
| author_sort | Sergio Veloso Brant Pinheiro |
| collection | DOAJ |
| description | In the past few years the understanding of the renin-angiotensin system (RAS) has improved, helping to better define the role of this system in physiological conditions and in human diseases. Besides Angiotensin (Ang) II, the biological importance of other Ang fragments was progressively evidenced. In this regard, Angiotensin- (Ang-) (1-7) was recognized as a biologically active product of the RAS cascade with a specific receptor, the G-protein-coupled receptor Mas, and that is mainly formed by the action of the angiotensin-converting enzyme (ACE) homolog enzyme, ACE2, which converts Ang II into Ang-(1-7). Taking into account the biological effects of these two mediators, Ang II and Ang-(1-7), the RAS can be envisioned as a dual function system in which the vasoconstrictor/proliferative or vasodilator/antiproliferative actions are primarily driven by the balance between Ang II and Ang-(1-7), respectively. In this paper, we will discuss our current understanding of the ACE2/Ang-(1-7)/Mas axis of the RAS in renal physiology and in the pathogenesis of primary hypertension and chronic kidney disease. |
| format | Article |
| id | doaj-art-c77b8e414d5e46b2828fd0971fac759c |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-c77b8e414d5e46b2828fd0971fac759c2025-02-03T06:08:48ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/414128414128Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the KidneySergio Veloso Brant Pinheiro0Ana Cristina Simões e Silva1Pediatric Nephrology Unit, Department of Pediatrics, Federal University of Minas Gerais (UFMG), 30130-100 Belo Horizonte MG, BrazilPediatric Nephrology Unit, Department of Pediatrics, Federal University of Minas Gerais (UFMG), 30130-100 Belo Horizonte MG, BrazilIn the past few years the understanding of the renin-angiotensin system (RAS) has improved, helping to better define the role of this system in physiological conditions and in human diseases. Besides Angiotensin (Ang) II, the biological importance of other Ang fragments was progressively evidenced. In this regard, Angiotensin- (Ang-) (1-7) was recognized as a biologically active product of the RAS cascade with a specific receptor, the G-protein-coupled receptor Mas, and that is mainly formed by the action of the angiotensin-converting enzyme (ACE) homolog enzyme, ACE2, which converts Ang II into Ang-(1-7). Taking into account the biological effects of these two mediators, Ang II and Ang-(1-7), the RAS can be envisioned as a dual function system in which the vasoconstrictor/proliferative or vasodilator/antiproliferative actions are primarily driven by the balance between Ang II and Ang-(1-7), respectively. In this paper, we will discuss our current understanding of the ACE2/Ang-(1-7)/Mas axis of the RAS in renal physiology and in the pathogenesis of primary hypertension and chronic kidney disease.http://dx.doi.org/10.1155/2012/414128 |
| spellingShingle | Sergio Veloso Brant Pinheiro Ana Cristina Simões e Silva Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney International Journal of Hypertension |
| title | Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney |
| title_full | Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney |
| title_fullStr | Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney |
| title_full_unstemmed | Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney |
| title_short | Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney |
| title_sort | angiotensin converting enzyme 2 angiotensin 1 7 and receptor mas axis in the kidney |
| url | http://dx.doi.org/10.1155/2012/414128 |
| work_keys_str_mv | AT sergiovelosobrantpinheiro angiotensinconvertingenzyme2angiotensin17andreceptormasaxisinthekidney AT anacristinasimoesesilva angiotensinconvertingenzyme2angiotensin17andreceptormasaxisinthekidney |