Clinical Effectiveness and Safety of Vericiguat in Worsening Heart Failure with Reduced Ejection Fraction: A Single-center, Retrospective Analysis in Indian Patients
Background and Objective: In a tertiary care hospital in India, investigators evaluated the efficacy and safety of vericiguat, a new oral soluble guanylate cyclase stimulator in patients with worsening symptoms of heart failure and reduced ejection fraction (HFrEF). Methods: A retrospective assessme...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of the Practice of Cardiovascular Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpcs.jpcs_63_24 |
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| author | Pankaj Jariwala Avvaru Guru Prakash Poondru Rohith Reddy Dilip Gude Gururaj Pramod Kulkarni Arshad Punjani Harikishan Boorugu Dilip Babu Madhawar Anusha Jariwala |
| author_facet | Pankaj Jariwala Avvaru Guru Prakash Poondru Rohith Reddy Dilip Gude Gururaj Pramod Kulkarni Arshad Punjani Harikishan Boorugu Dilip Babu Madhawar Anusha Jariwala |
| author_sort | Pankaj Jariwala |
| collection | DOAJ |
| description | Background and Objective:
In a tertiary care hospital in India, investigators evaluated the efficacy and safety of vericiguat, a new oral soluble guanylate cyclase stimulator in patients with worsening symptoms of heart failure and reduced ejection fraction (HFrEF).
Methods:
A retrospective assessment was conducted on patients with HFrEF and deteriorating symptoms who received either guideline-directed medical therapy (GDMT) or vericiguat, in addition to GDMT. The main result was a combination of death and hospitalization for heart failure (HF). Other measured results included systolic and diastolic blood pressure (DBP), left ventricular ejection fraction (LVEF), levels of N-terminal probrain natriuretic peptide (NT-pro BNP), kidney function, and sodium and potassium levels in the body.
Results:
After 6 months, 11 patients in the vericiguat group (22%) and 25 patients in the GDMT group (50%) experienced a primary composite event of death or hospitalization for HF. The administration of vericiguat resulted in a notable enhancement of the clinical indicators of HF, such as LVEF and NT-proBNP levels (P < 0.001). Administration of vericiguat at a dosage of 10 mg once a day, in conjunction with GDMT, did not have any negative effects on systolic or DBP, renal function, or electrolyte balance compared to GDMT alone.
Conclusion:
In patients experiencing deteriorating HF, the administration of vericiguat resulted in a notable decrease in cardiovascular mortality or hospitalization for HF compared with those who only received GDMT. This study emphasizes the efficacy and safety of vericiguat therapy in Indian patients with deteriorating HF. |
| format | Article |
| id | doaj-art-c7798a7441c347e99b514b3ccbe4315e |
| institution | Kabale University |
| issn | 2395-5414 2454-2830 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Practice of Cardiovascular Sciences |
| spelling | doaj-art-c7798a7441c347e99b514b3ccbe4315e2025-08-20T03:48:52ZengWolters Kluwer Medknow PublicationsJournal of the Practice of Cardiovascular Sciences2395-54142454-28302025-01-01111626910.4103/jpcs.jpcs_63_24Clinical Effectiveness and Safety of Vericiguat in Worsening Heart Failure with Reduced Ejection Fraction: A Single-center, Retrospective Analysis in Indian PatientsPankaj JariwalaAvvaru Guru PrakashPoondru Rohith ReddyDilip GudeGururaj Pramod KulkarniArshad PunjaniHarikishan BooruguDilip Babu MadhawarAnusha JariwalaBackground and Objective: In a tertiary care hospital in India, investigators evaluated the efficacy and safety of vericiguat, a new oral soluble guanylate cyclase stimulator in patients with worsening symptoms of heart failure and reduced ejection fraction (HFrEF). Methods: A retrospective assessment was conducted on patients with HFrEF and deteriorating symptoms who received either guideline-directed medical therapy (GDMT) or vericiguat, in addition to GDMT. The main result was a combination of death and hospitalization for heart failure (HF). Other measured results included systolic and diastolic blood pressure (DBP), left ventricular ejection fraction (LVEF), levels of N-terminal probrain natriuretic peptide (NT-pro BNP), kidney function, and sodium and potassium levels in the body. Results: After 6 months, 11 patients in the vericiguat group (22%) and 25 patients in the GDMT group (50%) experienced a primary composite event of death or hospitalization for HF. The administration of vericiguat resulted in a notable enhancement of the clinical indicators of HF, such as LVEF and NT-proBNP levels (P < 0.001). Administration of vericiguat at a dosage of 10 mg once a day, in conjunction with GDMT, did not have any negative effects on systolic or DBP, renal function, or electrolyte balance compared to GDMT alone. Conclusion: In patients experiencing deteriorating HF, the administration of vericiguat resulted in a notable decrease in cardiovascular mortality or hospitalization for HF compared with those who only received GDMT. This study emphasizes the efficacy and safety of vericiguat therapy in Indian patients with deteriorating HF.https://journals.lww.com/10.4103/jpcs.jpcs_63_24cardiovascular mortalityhospitalization for heart failuresoluble guanylyl cyclasevericiguatworsening heart failure |
| spellingShingle | Pankaj Jariwala Avvaru Guru Prakash Poondru Rohith Reddy Dilip Gude Gururaj Pramod Kulkarni Arshad Punjani Harikishan Boorugu Dilip Babu Madhawar Anusha Jariwala Clinical Effectiveness and Safety of Vericiguat in Worsening Heart Failure with Reduced Ejection Fraction: A Single-center, Retrospective Analysis in Indian Patients Journal of the Practice of Cardiovascular Sciences cardiovascular mortality hospitalization for heart failure soluble guanylyl cyclase vericiguat worsening heart failure |
| title | Clinical Effectiveness and Safety of Vericiguat in Worsening Heart Failure with Reduced Ejection Fraction: A Single-center, Retrospective Analysis in Indian Patients |
| title_full | Clinical Effectiveness and Safety of Vericiguat in Worsening Heart Failure with Reduced Ejection Fraction: A Single-center, Retrospective Analysis in Indian Patients |
| title_fullStr | Clinical Effectiveness and Safety of Vericiguat in Worsening Heart Failure with Reduced Ejection Fraction: A Single-center, Retrospective Analysis in Indian Patients |
| title_full_unstemmed | Clinical Effectiveness and Safety of Vericiguat in Worsening Heart Failure with Reduced Ejection Fraction: A Single-center, Retrospective Analysis in Indian Patients |
| title_short | Clinical Effectiveness and Safety of Vericiguat in Worsening Heart Failure with Reduced Ejection Fraction: A Single-center, Retrospective Analysis in Indian Patients |
| title_sort | clinical effectiveness and safety of vericiguat in worsening heart failure with reduced ejection fraction a single center retrospective analysis in indian patients |
| topic | cardiovascular mortality hospitalization for heart failure soluble guanylyl cyclase vericiguat worsening heart failure |
| url | https://journals.lww.com/10.4103/jpcs.jpcs_63_24 |
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