Direct measurement of the male germline mutation rate in individuals using sequential sperm samples

Direct measurement of the male germline mutation rate in individuals using sequential sperm samples

Abstract Mutations that accumulate in the human male germline with age are a major driver of genetic diversity and contribute to genetic diseases. However, aging-related male germline mutation rates have not been measured directly in germline cells (sperm) at the level of individuals. We developed a...

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Bibliographic Details
Main Authors: Jonathan E. Shoag, Amoolya Srinivasa, Caitlin A. Loh, Mei Hong Liu, Emilie Lassen, Shana Melanaphy, Benjamin M. Costa, Marta Grońska-Pęski, Nisrine T. Jabara, Shany Picciotto, Una Choi, Anyull D. Bohorquez, Christopher E. Barbieri, Pamela Callum, Anne-Bine Skytte, Gilad D. Evrony
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57507-0
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