A Photo-Controllable DNAzyme-Based Nanosensor for miRNA Imaging in Living Cells
MircroRNA (miRNA) exhibits abnormal expression in many cancer diseases, and the detection and analysis of miRNA are significant for the early diagnosis of diseases and research on miRNA functions. In this work, we construct a UV-triggered DNAzyme (UTD) nanosensor for the early detection of miRNA in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/13/4/123 |
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| author | Yanfei Zhang Yiling Zhang Runqi Ouyang Zong Dai Si-Yang Liu |
| author_facet | Yanfei Zhang Yiling Zhang Runqi Ouyang Zong Dai Si-Yang Liu |
| author_sort | Yanfei Zhang |
| collection | DOAJ |
| description | MircroRNA (miRNA) exhibits abnormal expression in many cancer diseases, and the detection and analysis of miRNA are significant for the early diagnosis of diseases and research on miRNA functions. In this work, we construct a UV-triggered DNAzyme (UTD) nanosensor for the early detection of miRNA in tumor cells. As the nanodevice was delivered into cells and irradiated by UV light, the controllable imaging of miRNA in living cells was achieved. This method effectively avoids false signal issues, providing a new strategy for high-spatiotemporal-resolution imaging of miRNA in living cells. |
| format | Article |
| id | doaj-art-c775544e724148f39b69a754f019d613 |
| institution | DOAJ |
| issn | 2227-9040 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj-art-c775544e724148f39b69a754f019d6132025-08-20T03:14:15ZengMDPI AGChemosensors2227-90402025-04-0113412310.3390/chemosensors13040123A Photo-Controllable DNAzyme-Based Nanosensor for miRNA Imaging in Living CellsYanfei Zhang0Yiling Zhang1Runqi Ouyang2Zong Dai3Si-Yang Liu4Guangdong Provincial Key Laboratory of Sensing Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-Sen University, Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, ChinaGuangdong Provincial Key Laboratory of Sensing Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-Sen University, Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, ChinaGuangdong Provincial Key Laboratory of Sensing Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-Sen University, Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, ChinaGuangdong Provincial Key Laboratory of Sensing Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-Sen University, Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, ChinaGuangdong Provincial Key Laboratory of Sensing Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-Sen University, Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, ChinaMircroRNA (miRNA) exhibits abnormal expression in many cancer diseases, and the detection and analysis of miRNA are significant for the early diagnosis of diseases and research on miRNA functions. In this work, we construct a UV-triggered DNAzyme (UTD) nanosensor for the early detection of miRNA in tumor cells. As the nanodevice was delivered into cells and irradiated by UV light, the controllable imaging of miRNA in living cells was achieved. This method effectively avoids false signal issues, providing a new strategy for high-spatiotemporal-resolution imaging of miRNA in living cells.https://www.mdpi.com/2227-9040/13/4/123DNAzymeMiRNA detectionphoto-controllablecell imaging |
| spellingShingle | Yanfei Zhang Yiling Zhang Runqi Ouyang Zong Dai Si-Yang Liu A Photo-Controllable DNAzyme-Based Nanosensor for miRNA Imaging in Living Cells Chemosensors DNAzyme MiRNA detection photo-controllable cell imaging |
| title | A Photo-Controllable DNAzyme-Based Nanosensor for miRNA Imaging in Living Cells |
| title_full | A Photo-Controllable DNAzyme-Based Nanosensor for miRNA Imaging in Living Cells |
| title_fullStr | A Photo-Controllable DNAzyme-Based Nanosensor for miRNA Imaging in Living Cells |
| title_full_unstemmed | A Photo-Controllable DNAzyme-Based Nanosensor for miRNA Imaging in Living Cells |
| title_short | A Photo-Controllable DNAzyme-Based Nanosensor for miRNA Imaging in Living Cells |
| title_sort | photo controllable dnazyme based nanosensor for mirna imaging in living cells |
| topic | DNAzyme MiRNA detection photo-controllable cell imaging |
| url | https://www.mdpi.com/2227-9040/13/4/123 |
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