Morphological Changes in the Aortic Wall after Blood Loss (An experimental Study)
Objective: to reveal aortic structural changes in the recovery period after longterm hemorrhagic hypotension and further blood reinfusion.Material and methods. Two (control and experimental) series of eexperiments were carried out on 10 out bred albino male rats in each. The animals were anesthetize...
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2014-08-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1410 |
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| author | A. A. Slavnov V. T. Dolgikh |
| author_facet | A. A. Slavnov V. T. Dolgikh |
| author_sort | A. A. Slavnov |
| collection | DOAJ |
| description | Objective: to reveal aortic structural changes in the recovery period after longterm hemorrhagic hypotension and further blood reinfusion.Material and methods. Two (control and experimental) series of eexperiments were carried out on 10 out bred albino male rats in each. The animals were anesthetized with sodium thiopental (25 mg/kg). Sixtyminute hemorrhagic hypotension (40 mm Hg) was induced by left common carotid artery catheterization, followed by blood reinfusion and wound closure. The animals were observed for 60 days, thereafter thoracic and abdominal aortic fragments were taken. The histological sections were stained with hematoxylin and eosin by the methods of Van Gieson, Verhoeff, and Veigert. Morphometric and histometric parameters, including the percentage of layers in the vascular wall and transmission capac ity coefficients, were determined.Results. The thoracic and abdominal aortic sections have been found to differ in morphometric parameters, which determined their different hemodynamic conditions in critical conditions. Hypertrophy of the media of the abdominal aorta due to thickening of the smooth muscle layers suggests that there are remodeling processes in its wall, which is accompanied by a smaller number of elastic membranes and by the expression of сollagencontaining structures after massive blood loss. For the thoracic aortic segment, such changes are manifested by a decreased medial area, a considerable advential thickening, and a drastic fall in transmission capacity coefficients.Conclusion. The found morphometric characteristics of different aortic segments should be considered as the basis for longlasting adaptation, which can supply blood to the vital organs as efficiently as possible in late recovery periods. |
| format | Article |
| id | doaj-art-c7734698a7e04c2aa1984c709dedd1cd |
| institution | Kabale University |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2014-08-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-c7734698a7e04c2aa1984c709dedd1cd2025-08-20T03:35:08ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102014-08-01104374310.15360/1813-9779-2014-4-37-431408Morphological Changes in the Aortic Wall after Blood Loss (An experimental Study)A. A. Slavnov0V. T. Dolgikh1Clinical Pathophysiology, Omsk State Medical Academy, Ministry of Health of the Russian Federation, OmskClinical Pathophysiology, Omsk State Medical Academy, Ministry of Health of the Russian Federation, OmskObjective: to reveal aortic structural changes in the recovery period after longterm hemorrhagic hypotension and further blood reinfusion.Material and methods. Two (control and experimental) series of eexperiments were carried out on 10 out bred albino male rats in each. The animals were anesthetized with sodium thiopental (25 mg/kg). Sixtyminute hemorrhagic hypotension (40 mm Hg) was induced by left common carotid artery catheterization, followed by blood reinfusion and wound closure. The animals were observed for 60 days, thereafter thoracic and abdominal aortic fragments were taken. The histological sections were stained with hematoxylin and eosin by the methods of Van Gieson, Verhoeff, and Veigert. Morphometric and histometric parameters, including the percentage of layers in the vascular wall and transmission capac ity coefficients, were determined.Results. The thoracic and abdominal aortic sections have been found to differ in morphometric parameters, which determined their different hemodynamic conditions in critical conditions. Hypertrophy of the media of the abdominal aorta due to thickening of the smooth muscle layers suggests that there are remodeling processes in its wall, which is accompanied by a smaller number of elastic membranes and by the expression of сollagencontaining structures after massive blood loss. For the thoracic aortic segment, such changes are manifested by a decreased medial area, a considerable advential thickening, and a drastic fall in transmission capacity coefficients.Conclusion. The found morphometric characteristics of different aortic segments should be considered as the basis for longlasting adaptation, which can supply blood to the vital organs as efficiently as possible in late recovery periods.https://www.reanimatology.com/rmt/article/view/1410hemorrhagic hypotensionblood reinfusionaortic structural changes |
| spellingShingle | A. A. Slavnov V. T. Dolgikh Morphological Changes in the Aortic Wall after Blood Loss (An experimental Study) Общая реаниматология hemorrhagic hypotension blood reinfusion aortic structural changes |
| title | Morphological Changes in the Aortic Wall after Blood Loss (An experimental Study) |
| title_full | Morphological Changes in the Aortic Wall after Blood Loss (An experimental Study) |
| title_fullStr | Morphological Changes in the Aortic Wall after Blood Loss (An experimental Study) |
| title_full_unstemmed | Morphological Changes in the Aortic Wall after Blood Loss (An experimental Study) |
| title_short | Morphological Changes in the Aortic Wall after Blood Loss (An experimental Study) |
| title_sort | morphological changes in the aortic wall after blood loss an experimental study |
| topic | hemorrhagic hypotension blood reinfusion aortic structural changes |
| url | https://www.reanimatology.com/rmt/article/view/1410 |
| work_keys_str_mv | AT aaslavnov morphologicalchangesintheaorticwallafterbloodlossanexperimentalstudy AT vtdolgikh morphologicalchangesintheaorticwallafterbloodlossanexperimentalstudy |