Research progress of Mendelian randomization analysis for glaucoma etiology
In recent years, Mendelian randomization (MR) has been increasingly utilized, leveraging genetic variants as instrumental variables. This approach significantly mitigates confounder effects and reverse causation, precisely clarifying the causal links between exposures and outcomes. MR's unique...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2025-07-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2025/7/20250723.pdf |
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| author | Jiao-Man Wang Yin-Wei Song Jing-Jing Su Li-Cheng Fu Di Gong Ping Guo Wei-Hua Yang |
| author_facet | Jiao-Man Wang Yin-Wei Song Jing-Jing Su Li-Cheng Fu Di Gong Ping Guo Wei-Hua Yang |
| author_sort | Jiao-Man Wang |
| collection | DOAJ |
| description | In recent years, Mendelian randomization (MR) has been increasingly utilized, leveraging genetic variants as instrumental variables. This approach significantly mitigates confounder effects and reverse causation, precisely clarifying the causal links between exposures and outcomes. MR's unique advantages have made it instrumental in medicine, especially in elucidating glaucoma's etiology. It facilitates the identification of potential risk factors, laying the groundwork for developing preventative and therapeutic strategies against glaucoma. Recent MR research has delved into diverse potential glaucoma risk factors, including behavioral habits, metabolic profiles, and their causative linkage to the disease. This review encapsulates MR's analysis in glaucoma etiology, heralding new avenues for understanding underlying mechanisms and establishing causality. |
| format | Article |
| id | doaj-art-c770bc93be344a2fba53ffaed54ea979 |
| institution | OA Journals |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj-art-c770bc93be344a2fba53ffaed54ea9792025-08-20T02:09:24ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-07-011871383139710.18240/ijo.2025.07.2320250723Research progress of Mendelian randomization analysis for glaucoma etiologyJiao-Man Wang0Yin-Wei Song1Jing-Jing Su2Li-Cheng Fu3Di Gong4Ping Guo5Wei-Hua Yang6Ping Guo and Wei-Hua Yang. Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, No.18 Zetian Road, Futian District, Shenzhen 518040, Guangdong Province, China. 2607212858@qq.com; benben0606@139.comShenzhen People's Hospital (the Second Clinical Medical College, Jinan Universitythe First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong Province, ChinaShenzhen People's Hospital (the Second Clinical Medical College, Jinan Universitythe First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong Province, Chinathe First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong Province, Chinathe First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong Province, ChinaIn recent years, Mendelian randomization (MR) has been increasingly utilized, leveraging genetic variants as instrumental variables. This approach significantly mitigates confounder effects and reverse causation, precisely clarifying the causal links between exposures and outcomes. MR's unique advantages have made it instrumental in medicine, especially in elucidating glaucoma's etiology. It facilitates the identification of potential risk factors, laying the groundwork for developing preventative and therapeutic strategies against glaucoma. Recent MR research has delved into diverse potential glaucoma risk factors, including behavioral habits, metabolic profiles, and their causative linkage to the disease. This review encapsulates MR's analysis in glaucoma etiology, heralding new avenues for understanding underlying mechanisms and establishing causality.http://ies.ijo.cn/en_publish/2025/7/20250723.pdfmendelian randomizationglaucomaetiologyrisk factors |
| spellingShingle | Jiao-Man Wang Yin-Wei Song Jing-Jing Su Li-Cheng Fu Di Gong Ping Guo Wei-Hua Yang Research progress of Mendelian randomization analysis for glaucoma etiology International Journal of Ophthalmology mendelian randomization glaucoma etiology risk factors |
| title | Research progress of Mendelian randomization analysis for glaucoma etiology |
| title_full | Research progress of Mendelian randomization analysis for glaucoma etiology |
| title_fullStr | Research progress of Mendelian randomization analysis for glaucoma etiology |
| title_full_unstemmed | Research progress of Mendelian randomization analysis for glaucoma etiology |
| title_short | Research progress of Mendelian randomization analysis for glaucoma etiology |
| title_sort | research progress of mendelian randomization analysis for glaucoma etiology |
| topic | mendelian randomization glaucoma etiology risk factors |
| url | http://ies.ijo.cn/en_publish/2025/7/20250723.pdf |
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