Guardians of the sea: molecular and biochemical adaptations in sharks and whales for atherosclerosis resistance and their potential in human cardioprotection

Guardians of the sea: molecular and biochemical adaptations in sharks and whales for atherosclerosis resistance and their potential in human cardioprotection

Abstract This review explores unique molecular and biochemical adaptations in sharks and whales that confer resistance to atherosclerosis despite high lipid concentrations, unlike atherosclerosis-prone terrestrial mammals (e.g., humans, primates) and shorter-lived marine species (e.g., seals, dolphi...

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Bibliographic Details
Main Authors: Raymond Rubianto Tjandrawinata, Isabela Caiado Caixeta Vencio, Axel Brahmantyo Maynardo Nugroho, Jonathan Hartanto, Nicolas Daniel Widjanarko, Fahrul Nurkolis
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Atherosclerosis
Cardioprotection
Lipidomics
Omega-3 PUFAs
Shark cartilage peptides
Aminosterols
Online Access:https://doi.org/10.1186/s13098-025-01868-5
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