Aerobic Exercise Practiced Over Time Mitigates the Structural Effects on the Vascular System Caused by the Deleterious Effects of Aging
Rafael Antunes Nicoletti,1,2 Thiago Pereira de Souza,1,2 Danyelle S Miotto,3 Francine Duchatsch,3 Lidieli Pazin Tardelli,3 Vinicius Ferreira de Paula,3 Sandra Lia Amaral,1,3 Anderson Saranz Zago1,2 1Department of Physical Education, School of Sciences, Sao Paulo State University (UNESP), Bauru, Braz...
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Dove Medical Press
2025-03-01
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| Series: | Vascular Health and Risk Management |
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| author | Nicoletti RA Souza TP Miotto DS Duchatsch F Tardelli LP de Paula VF Amaral SL Zago AS |
| author_facet | Nicoletti RA Souza TP Miotto DS Duchatsch F Tardelli LP de Paula VF Amaral SL Zago AS |
| author_sort | Nicoletti RA |
| collection | DOAJ |
| description | Rafael Antunes Nicoletti,1,2 Thiago Pereira de Souza,1,2 Danyelle S Miotto,3 Francine Duchatsch,3 Lidieli Pazin Tardelli,3 Vinicius Ferreira de Paula,3 Sandra Lia Amaral,1,3 Anderson Saranz Zago1,2 1Department of Physical Education, School of Sciences, Sao Paulo State University (UNESP), Bauru, Brazil; 2Graduate Program in Movement Science, Sao Paulo State University, UNESP, SP, Brazil; 3Joint Graduate Program in Physiological SciencesPIPGCF Ufscar/UNESP, São Carlos, BrazilCorrespondence: Anderson Saranz Zago, Sao Paulo State University (UNESP) – Bauru/São Paulo/Brazil, Tel +55-14-3103-6082 - Extension-9436, Email anderson.zago@unesp.brBackground: Aerobic training has been considered beneficial for determining the detrimental alterations in blood vessels caused by aging.Objective: Evaluate the relationship between the preventive effects of aerobic exercise and time of practice on cardiovascular health, in aged Wistar rats.Methods: Wistar rats (16 months) were divided into 3 groups: (1) sedentary (AGED); (2) long-term trained\61 weeks (LTT); and (3) short-term trained\final 8 weeks of life (STT). Body weight, maximum physical capacity, systolic blood pressure (SBP), pulse wave velocity (PWV), plasma nitrite (NO), oxidative stress (TBARS), wall thickness, the wall-to-lumen ratio, and collagen of the thoracic aorta, carotid, and femoral arteries were measured.Results: Both trained groups showed an increase in physical capacity when compared to the AGED group (p=< 0.001 for LTT and p=0.011 for STT), and the LTT group demonstrated higher values when compared to the STT group (p= 0.004). The LTT group presented attenuation of PWV (p= 0.002) and a reduction in the wall thickness and wall-to-lumen ratio of the thoracic aorta (p=0.032 and 0.008, respectively) and carotid arteries (p=0.019 and 0.012, respectively) when compared to the AGED group. The STT group presented a reduction in TBARS compared to the AGED group (p=0.046). Additionally, both trained groups (LTT and STT) presented a reduction in the percentage of arterial collagen compared to the AGED group in the thoracic aorta (p=< 0.001 and p=0.001 respectively) and carotid arteries (p= < 0.008 and p= 0.041 respectively).Conclusion: This study demonstrated that long-term training decreased the level of collagen, PWV values, wall thickness, and the wall-to-lumen ratio of the aorta and carotid arteries compared to the AGED group. Moreover, short-term training reduced TBARS and collagen percentage in the aorta and carotid arteries compared to the AGED group.Keywords: aging, aerobic training, pulse wave velocity, collagen deposition, arteries |
| format | Article |
| id | doaj-art-c76ecccf51cf43f091baca307e6c9f9f |
| institution | DOAJ |
| issn | 1178-2048 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj-art-c76ecccf51cf43f091baca307e6c9f9f2025-08-20T02:51:34ZengDove Medical PressVascular Health and Risk Management1178-20482025-03-01Volume 21125138101297Aerobic Exercise Practiced Over Time Mitigates the Structural Effects on the Vascular System Caused by the Deleterious Effects of AgingNicoletti RASouza TPMiotto DSDuchatsch FTardelli LPde Paula VFAmaral SLZago ASRafael Antunes Nicoletti,1,2 Thiago Pereira de Souza,1,2 Danyelle S Miotto,3 Francine Duchatsch,3 Lidieli Pazin Tardelli,3 Vinicius Ferreira de Paula,3 Sandra Lia Amaral,1,3 Anderson Saranz Zago1,2 1Department of Physical Education, School of Sciences, Sao Paulo State University (UNESP), Bauru, Brazil; 2Graduate Program in Movement Science, Sao Paulo State University, UNESP, SP, Brazil; 3Joint Graduate Program in Physiological SciencesPIPGCF Ufscar/UNESP, São Carlos, BrazilCorrespondence: Anderson Saranz Zago, Sao Paulo State University (UNESP) – Bauru/São Paulo/Brazil, Tel +55-14-3103-6082 - Extension-9436, Email anderson.zago@unesp.brBackground: Aerobic training has been considered beneficial for determining the detrimental alterations in blood vessels caused by aging.Objective: Evaluate the relationship between the preventive effects of aerobic exercise and time of practice on cardiovascular health, in aged Wistar rats.Methods: Wistar rats (16 months) were divided into 3 groups: (1) sedentary (AGED); (2) long-term trained\61 weeks (LTT); and (3) short-term trained\final 8 weeks of life (STT). Body weight, maximum physical capacity, systolic blood pressure (SBP), pulse wave velocity (PWV), plasma nitrite (NO), oxidative stress (TBARS), wall thickness, the wall-to-lumen ratio, and collagen of the thoracic aorta, carotid, and femoral arteries were measured.Results: Both trained groups showed an increase in physical capacity when compared to the AGED group (p=< 0.001 for LTT and p=0.011 for STT), and the LTT group demonstrated higher values when compared to the STT group (p= 0.004). The LTT group presented attenuation of PWV (p= 0.002) and a reduction in the wall thickness and wall-to-lumen ratio of the thoracic aorta (p=0.032 and 0.008, respectively) and carotid arteries (p=0.019 and 0.012, respectively) when compared to the AGED group. The STT group presented a reduction in TBARS compared to the AGED group (p=0.046). Additionally, both trained groups (LTT and STT) presented a reduction in the percentage of arterial collagen compared to the AGED group in the thoracic aorta (p=< 0.001 and p=0.001 respectively) and carotid arteries (p= < 0.008 and p= 0.041 respectively).Conclusion: This study demonstrated that long-term training decreased the level of collagen, PWV values, wall thickness, and the wall-to-lumen ratio of the aorta and carotid arteries compared to the AGED group. Moreover, short-term training reduced TBARS and collagen percentage in the aorta and carotid arteries compared to the AGED group.Keywords: aging, aerobic training, pulse wave velocity, collagen deposition, arterieshttps://www.dovepress.com/aerobic-exercise-practiced-over-time-mitigates-the-structural-effects--peer-reviewed-fulltext-article-VHRMagingaerobic trainingpulse wave velocitycollagen depositionarteries. |
| spellingShingle | Nicoletti RA Souza TP Miotto DS Duchatsch F Tardelli LP de Paula VF Amaral SL Zago AS Aerobic Exercise Practiced Over Time Mitigates the Structural Effects on the Vascular System Caused by the Deleterious Effects of Aging Vascular Health and Risk Management aging aerobic training pulse wave velocity collagen deposition arteries. |
| title | Aerobic Exercise Practiced Over Time Mitigates the Structural Effects on the Vascular System Caused by the Deleterious Effects of Aging |
| title_full | Aerobic Exercise Practiced Over Time Mitigates the Structural Effects on the Vascular System Caused by the Deleterious Effects of Aging |
| title_fullStr | Aerobic Exercise Practiced Over Time Mitigates the Structural Effects on the Vascular System Caused by the Deleterious Effects of Aging |
| title_full_unstemmed | Aerobic Exercise Practiced Over Time Mitigates the Structural Effects on the Vascular System Caused by the Deleterious Effects of Aging |
| title_short | Aerobic Exercise Practiced Over Time Mitigates the Structural Effects on the Vascular System Caused by the Deleterious Effects of Aging |
| title_sort | aerobic exercise practiced over time mitigates the structural effects on the vascular system caused by the deleterious effects of aging |
| topic | aging aerobic training pulse wave velocity collagen deposition arteries. |
| url | https://www.dovepress.com/aerobic-exercise-practiced-over-time-mitigates-the-structural-effects--peer-reviewed-fulltext-article-VHRM |
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