Maxillary Sinus Inflammatory Myofibroblastic Tumors: A Review and Case Report
An inflammatory myofibroblastic tumor (IMT) is an immunohistochemically diverse entity demonstrating neoplastic and nonneoplastic qualities. Although IMTs can arise in any area of the body, lesions arising in certain sites, namely, the nasal cavity, paranasal sinuses, and pterygopalatine fossa, demo...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/953857 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850172434140889088 |
|---|---|
| author | Chase C. Hansen Colby Eisenbach Carlos Torres Suzanne Graham Fred Hardwicke |
| author_facet | Chase C. Hansen Colby Eisenbach Carlos Torres Suzanne Graham Fred Hardwicke |
| author_sort | Chase C. Hansen |
| collection | DOAJ |
| description | An inflammatory myofibroblastic tumor (IMT) is an immunohistochemically diverse entity demonstrating neoplastic and nonneoplastic qualities. Although IMTs can arise in any area of the body, lesions arising in certain sites, namely, the nasal cavity, paranasal sinuses, and pterygopalatine fossa, demonstrate a heightened neoplastic and invasive potential. Despite case specific complete tumor regression and disease remission in response to pharmacotherapeutics, a subset of IMTs remain resistant to all forms of therapy. We present such a case, a 34-year-old female patient, with a highly resistant, maxillary sinus IMT. Her refractory, ALK-1 negative IMT has not responded well to novel therapies reported in current literature. This case suggests the role of zonal expressivity within a single lesion as a probable mechanism for its highly resistant nature and should promote determination of each IMT’s cytogenetic profile to provide more effective targeted therapy. Paper includes a literature review of all maxillary sinus IMTs from 1985 to 2014 along with their immunohistochemical staining, treatments, and outcomes. |
| format | Article |
| id | doaj-art-c76cf928c57a498f972bd4ea56fffca2 |
| institution | OA Journals |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-c76cf928c57a498f972bd4ea56fffca22025-08-20T02:20:06ZengWileyCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/953857953857Maxillary Sinus Inflammatory Myofibroblastic Tumors: A Review and Case ReportChase C. Hansen0Colby Eisenbach1Carlos Torres2Suzanne Graham3Fred Hardwicke4Department of Radiation Oncology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USADepartment of Radiation Oncology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USADepartment of Radiation Oncology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USADepartment of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USADepartment of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USAAn inflammatory myofibroblastic tumor (IMT) is an immunohistochemically diverse entity demonstrating neoplastic and nonneoplastic qualities. Although IMTs can arise in any area of the body, lesions arising in certain sites, namely, the nasal cavity, paranasal sinuses, and pterygopalatine fossa, demonstrate a heightened neoplastic and invasive potential. Despite case specific complete tumor regression and disease remission in response to pharmacotherapeutics, a subset of IMTs remain resistant to all forms of therapy. We present such a case, a 34-year-old female patient, with a highly resistant, maxillary sinus IMT. Her refractory, ALK-1 negative IMT has not responded well to novel therapies reported in current literature. This case suggests the role of zonal expressivity within a single lesion as a probable mechanism for its highly resistant nature and should promote determination of each IMT’s cytogenetic profile to provide more effective targeted therapy. Paper includes a literature review of all maxillary sinus IMTs from 1985 to 2014 along with their immunohistochemical staining, treatments, and outcomes.http://dx.doi.org/10.1155/2015/953857 |
| spellingShingle | Chase C. Hansen Colby Eisenbach Carlos Torres Suzanne Graham Fred Hardwicke Maxillary Sinus Inflammatory Myofibroblastic Tumors: A Review and Case Report Case Reports in Oncological Medicine |
| title | Maxillary Sinus Inflammatory Myofibroblastic Tumors: A Review and Case Report |
| title_full | Maxillary Sinus Inflammatory Myofibroblastic Tumors: A Review and Case Report |
| title_fullStr | Maxillary Sinus Inflammatory Myofibroblastic Tumors: A Review and Case Report |
| title_full_unstemmed | Maxillary Sinus Inflammatory Myofibroblastic Tumors: A Review and Case Report |
| title_short | Maxillary Sinus Inflammatory Myofibroblastic Tumors: A Review and Case Report |
| title_sort | maxillary sinus inflammatory myofibroblastic tumors a review and case report |
| url | http://dx.doi.org/10.1155/2015/953857 |
| work_keys_str_mv | AT chasechansen maxillarysinusinflammatorymyofibroblastictumorsareviewandcasereport AT colbyeisenbach maxillarysinusinflammatorymyofibroblastictumorsareviewandcasereport AT carlostorres maxillarysinusinflammatorymyofibroblastictumorsareviewandcasereport AT suzannegraham maxillarysinusinflammatorymyofibroblastictumorsareviewandcasereport AT fredhardwicke maxillarysinusinflammatorymyofibroblastictumorsareviewandcasereport |