Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance
Ovarian cancer is a highly deadly disease, which is often diagnosed at a late stage with metastases. However, most ovarian cancers relapse after surgery combined with platinum-based chemotherapy. Cancer stem cells (CSCs) are stem-like cells that possess high tumorigenic capability and display higher...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/8860185 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850172432805003264 |
|---|---|
| author | Guo-Qing Chen Ping Ye Rong-Song Ling Fa Zeng Xiong-Shan Zhu Lu Chen Yan Huang Ling Xu Xiao-Ying Xie |
| author_facet | Guo-Qing Chen Ping Ye Rong-Song Ling Fa Zeng Xiong-Shan Zhu Lu Chen Yan Huang Ling Xu Xiao-Ying Xie |
| author_sort | Guo-Qing Chen |
| collection | DOAJ |
| description | Ovarian cancer is a highly deadly disease, which is often diagnosed at a late stage with metastases. However, most ovarian cancers relapse after surgery combined with platinum-based chemotherapy. Cancer stem cells (CSCs) are stem-like cells that possess high tumorigenic capability and display higher resistant capability against current therapies. However, our knowledge of ovarian CSCs and their molecular mechanism remains sparse. In the current study, we found that KDM4C, a histone demethylase, was required for ovarian cancer stem cell (CSC) maintenance. Depletion of KDM4C significantly reduced the CSC population and sphere formation in vitro. Moreover, we found that KDM4C can regulate the expression of stem cell factor OCT-4 via binding to its promoter. These data indicate that KDM4C is relevant for ovarian CSC maintenance and underscore its importance as a potential therapeutic target. |
| format | Article |
| id | doaj-art-c7656a3944a74be19df79ec39ad5e8df |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-c7656a3944a74be19df79ec39ad5e8df2025-08-20T02:20:06ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/88601858860185Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell MaintenanceGuo-Qing Chen0Ping Ye1Rong-Song Ling2Fa Zeng3Xiong-Shan Zhu4Lu Chen5Yan Huang6Ling Xu7Xiao-Ying Xie8Department of Obstetrics, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Guangdong, ChinaDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Gannan Medical University, Jiangxi, ChinaInstitute for Advanced Study, Shenzhen University, Shenzhen, ChinaDepartment of Obstetrics, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Guangdong, ChinaDepartment of Obstetrics, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Guangdong, ChinaDepartment of Obstetrics, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Guangdong, ChinaDepartment of Obstetrics, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Guangdong, ChinaDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Gannan Medical University, Jiangxi, ChinaDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Gannan Medical University, Jiangxi, ChinaOvarian cancer is a highly deadly disease, which is often diagnosed at a late stage with metastases. However, most ovarian cancers relapse after surgery combined with platinum-based chemotherapy. Cancer stem cells (CSCs) are stem-like cells that possess high tumorigenic capability and display higher resistant capability against current therapies. However, our knowledge of ovarian CSCs and their molecular mechanism remains sparse. In the current study, we found that KDM4C, a histone demethylase, was required for ovarian cancer stem cell (CSC) maintenance. Depletion of KDM4C significantly reduced the CSC population and sphere formation in vitro. Moreover, we found that KDM4C can regulate the expression of stem cell factor OCT-4 via binding to its promoter. These data indicate that KDM4C is relevant for ovarian CSC maintenance and underscore its importance as a potential therapeutic target.http://dx.doi.org/10.1155/2020/8860185 |
| spellingShingle | Guo-Qing Chen Ping Ye Rong-Song Ling Fa Zeng Xiong-Shan Zhu Lu Chen Yan Huang Ling Xu Xiao-Ying Xie Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance Stem Cells International |
| title | Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance |
| title_full | Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance |
| title_fullStr | Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance |
| title_full_unstemmed | Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance |
| title_short | Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance |
| title_sort | histone demethylase kdm4c is required for ovarian cancer stem cell maintenance |
| url | http://dx.doi.org/10.1155/2020/8860185 |
| work_keys_str_mv | AT guoqingchen histonedemethylasekdm4cisrequiredforovariancancerstemcellmaintenance AT pingye histonedemethylasekdm4cisrequiredforovariancancerstemcellmaintenance AT rongsongling histonedemethylasekdm4cisrequiredforovariancancerstemcellmaintenance AT fazeng histonedemethylasekdm4cisrequiredforovariancancerstemcellmaintenance AT xiongshanzhu histonedemethylasekdm4cisrequiredforovariancancerstemcellmaintenance AT luchen histonedemethylasekdm4cisrequiredforovariancancerstemcellmaintenance AT yanhuang histonedemethylasekdm4cisrequiredforovariancancerstemcellmaintenance AT lingxu histonedemethylasekdm4cisrequiredforovariancancerstemcellmaintenance AT xiaoyingxie histonedemethylasekdm4cisrequiredforovariancancerstemcellmaintenance |