An Activity of Flavonoid Derived Compounds from Medinilla speciosa Extract as Anti-hyperpigmentation against Tyrosinease Proteins with In Silico Methods
Parijoto (Medinilla speciosa), a typical plant from Indonesia, contains flavonoid compounds as antioxidants. It is able to depigment skin by inhibiting tyrosinase activity during melanogenesis, or melanin formation. Melanogenesis occurs through UV light exposure; it stimulates ROS production and tr...
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Universitas Nahdlatul Ulama Surabaya
2024-05-01
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| Series: | Jurnal Ilmiah Kesehatan |
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| Online Access: | https://journal2.unusa.ac.id/index.php/JHS/article/view/5107 |
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| author | elshinta riantica Awik Puji Dyah Nurhayati Noor Nailis Sa’adah |
| author_facet | elshinta riantica Awik Puji Dyah Nurhayati Noor Nailis Sa’adah |
| author_sort | elshinta riantica |
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Parijoto (Medinilla speciosa), a typical plant from Indonesia, contains flavonoid compounds as antioxidants. It is able to depigment skin by inhibiting tyrosinase activity during melanogenesis, or melanin formation. Melanogenesis occurs through UV light exposure; it stimulates ROS production and triggers the formation of free radicals and melanogenesis. If not prevented, it will have negative impacts on health. Currently, there is no further research regarding the existence of flavonoid compound derivatives found in parijoto fruit. The aim of this research is to initially identify potential flavonoid derivative compounds as tyrosinase inhibitors using in silico methods. The results can be used as an initial reference for making products based on natural ingredients with minimal side effects. This research uses a bioinformatics approach with the molecular docking method of ligands towards proteins. The stages in this research include: downloading and preparing receptors and ligands; docking with Autodock Vina; visualization of results with Biovia Discovery Studio; data analysis; and discussion. The analysis is carried out by looking at the affinity energy values and complex conformation between the receptor-ligand. The results show flavonoid derivative compounds have the potential to act as tyrosinase inhibitors, as proven by compounds interactions with the active site of tyrosinase to produce the amino acid residues phenylalanine, proline, asparagine, arginine, and histamine. Produce respective affinity energy values, namely -8.9; -7.7; -7.6; -7.5; -7.5; and 7.4 kcal/mol for chalcone, catechin, flavonol, flavanol, flavone, and flavonone compounds. Meanwhile, the comparison compound used is kojic acid, with an affinity energy of -5.5 kcal/mol.
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| format | Article |
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| institution | OA Journals |
| issn | 1978-6743 2477-3948 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Universitas Nahdlatul Ulama Surabaya |
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| series | Jurnal Ilmiah Kesehatan |
| spelling | doaj-art-c763c0f7e26b48faadccfc8a72f180402025-08-20T02:22:39ZengUniversitas Nahdlatul Ulama SurabayaJurnal Ilmiah Kesehatan1978-67432477-39482024-05-01170210.33086/jhs.v17i02.5107An Activity of Flavonoid Derived Compounds from Medinilla speciosa Extract as Anti-hyperpigmentation against Tyrosinease Proteins with In Silico Methodselshinta riantica0Awik Puji Dyah Nurhayati1Noor Nailis Sa’adah2Institut Teknologi Sepuluh NopemberBiologi Department, Faculty of Sains and Data Analitics, Institut Teknologi Sepuluh Nopember, Surabaya, Indonesia Biologi Department, Faculty of Sains and Data Analitics, Institut Teknologi Sepuluh Nopember, Surabaya, Indonesia Parijoto (Medinilla speciosa), a typical plant from Indonesia, contains flavonoid compounds as antioxidants. It is able to depigment skin by inhibiting tyrosinase activity during melanogenesis, or melanin formation. Melanogenesis occurs through UV light exposure; it stimulates ROS production and triggers the formation of free radicals and melanogenesis. If not prevented, it will have negative impacts on health. Currently, there is no further research regarding the existence of flavonoid compound derivatives found in parijoto fruit. The aim of this research is to initially identify potential flavonoid derivative compounds as tyrosinase inhibitors using in silico methods. The results can be used as an initial reference for making products based on natural ingredients with minimal side effects. This research uses a bioinformatics approach with the molecular docking method of ligands towards proteins. The stages in this research include: downloading and preparing receptors and ligands; docking with Autodock Vina; visualization of results with Biovia Discovery Studio; data analysis; and discussion. The analysis is carried out by looking at the affinity energy values and complex conformation between the receptor-ligand. The results show flavonoid derivative compounds have the potential to act as tyrosinase inhibitors, as proven by compounds interactions with the active site of tyrosinase to produce the amino acid residues phenylalanine, proline, asparagine, arginine, and histamine. Produce respective affinity energy values, namely -8.9; -7.7; -7.6; -7.5; -7.5; and 7.4 kcal/mol for chalcone, catechin, flavonol, flavanol, flavone, and flavonone compounds. Meanwhile, the comparison compound used is kojic acid, with an affinity energy of -5.5 kcal/mol. https://journal2.unusa.ac.id/index.php/JHS/article/view/5107DockingFlavonoidParijotoTyrosinase |
| spellingShingle | elshinta riantica Awik Puji Dyah Nurhayati Noor Nailis Sa’adah An Activity of Flavonoid Derived Compounds from Medinilla speciosa Extract as Anti-hyperpigmentation against Tyrosinease Proteins with In Silico Methods Jurnal Ilmiah Kesehatan Docking Flavonoid Parijoto Tyrosinase |
| title | An Activity of Flavonoid Derived Compounds from Medinilla speciosa Extract as Anti-hyperpigmentation against Tyrosinease Proteins with In Silico Methods |
| title_full | An Activity of Flavonoid Derived Compounds from Medinilla speciosa Extract as Anti-hyperpigmentation against Tyrosinease Proteins with In Silico Methods |
| title_fullStr | An Activity of Flavonoid Derived Compounds from Medinilla speciosa Extract as Anti-hyperpigmentation against Tyrosinease Proteins with In Silico Methods |
| title_full_unstemmed | An Activity of Flavonoid Derived Compounds from Medinilla speciosa Extract as Anti-hyperpigmentation against Tyrosinease Proteins with In Silico Methods |
| title_short | An Activity of Flavonoid Derived Compounds from Medinilla speciosa Extract as Anti-hyperpigmentation against Tyrosinease Proteins with In Silico Methods |
| title_sort | activity of flavonoid derived compounds from medinilla speciosa extract as anti hyperpigmentation against tyrosinease proteins with in silico methods |
| topic | Docking Flavonoid Parijoto Tyrosinase |
| url | https://journal2.unusa.ac.id/index.php/JHS/article/view/5107 |
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