Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives
Several new 1-(4-diarylmethylpiperazine-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione derivatives were synthesized by acylation of 1-diarylmethylpiperazine with 2-(1H-indol-3-yl)-2-oxoacetyl chloride. Their structures were confirmed by 1H NMR, IR, mass spectra, and elemental analysis. These compounds were...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/4617454 |
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| author | Jun-Rong Jiang Feng Xu Han-Gui Wu |
| author_facet | Jun-Rong Jiang Feng Xu Han-Gui Wu |
| author_sort | Jun-Rong Jiang |
| collection | DOAJ |
| description | Several new 1-(4-diarylmethylpiperazine-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione derivatives were synthesized by acylation of 1-diarylmethylpiperazine with 2-(1H-indol-3-yl)-2-oxoacetyl chloride. Their structures were confirmed by 1H NMR, IR, mass spectra, and elemental analysis. These compounds were further evaluated for their anticancer activity, and most of them were found to have moderate-to-potent antiproliferative activities against Hela, A-549, and ECA-109 cancer cell lines in vitro. |
| format | Article |
| id | doaj-art-c762b52d5b444ef998e8b728e1866215 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-c762b52d5b444ef998e8b728e18662152025-02-03T01:21:54ZengWileyJournal of Chemistry2090-90632090-90712016-01-01201610.1155/2016/46174544617454Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione DerivativesJun-Rong Jiang0Feng Xu1Han-Gui Wu2Chemical Pharmaceutical Research Institute, Taizhou Vocational & Technical College, Zhejiang, Taizhou 318000, ChinaChemical Pharmaceutical Research Institute, Taizhou Vocational & Technical College, Zhejiang, Taizhou 318000, ChinaChemical Pharmaceutical Research Institute, Taizhou Vocational & Technical College, Zhejiang, Taizhou 318000, ChinaSeveral new 1-(4-diarylmethylpiperazine-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione derivatives were synthesized by acylation of 1-diarylmethylpiperazine with 2-(1H-indol-3-yl)-2-oxoacetyl chloride. Their structures were confirmed by 1H NMR, IR, mass spectra, and elemental analysis. These compounds were further evaluated for their anticancer activity, and most of them were found to have moderate-to-potent antiproliferative activities against Hela, A-549, and ECA-109 cancer cell lines in vitro.http://dx.doi.org/10.1155/2016/4617454 |
| spellingShingle | Jun-Rong Jiang Feng Xu Han-Gui Wu Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives Journal of Chemistry |
| title | Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives |
| title_full | Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives |
| title_fullStr | Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives |
| title_full_unstemmed | Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives |
| title_short | Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives |
| title_sort | synthesis and anticancer activity of 1 1h indol 3 yl 2 4 diarylmethylpiperazine 1 yl ethane 1 2 dione derivatives |
| url | http://dx.doi.org/10.1155/2016/4617454 |
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