Platelets associated antibodies pre and post splenectomy in Hepatitis C patients with thrombocytopenia
Back ground: The presence of platelet antibodies in inducing thrombocytopenia in patients with HCV infection is a matter of great debate. Subjects and methods: The present study was conducted on 123 subjects categorized as follows: Group 1: included 23 cases diagnosed as patients with HCV liver...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1713 |
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| Summary: | Back ground: The presence of platelet antibodies in inducing thrombocytopenia in patients with HCV infection is a matter of great debate.
Subjects and methods:
The present study was conducted on 123 subjects categorized as follows:
Group 1: included 23 cases diagnosed as patients with HCV liver cirrhosis splenectomy. Group 2: included the same 23 cases after splenectomy. For all subjects included in this study platelets counts was evaluated as well as platelets associated antibodies (IgM, IgG, IgA)
Results
All patients were thrombocytopenic before undergone splenectomy (Platelet counts (median 68.5; range 44-95). After splenectomy all patients were of normal platelet counts (median 180; range 108- 235). The mean ±SD of platelets associated immunoglobulin were 64.2±9.6 for total IgG, 53.6±8.1 for IgG, 3.8±2.1 for IgM, 6.7±4.7 presplenectomy versus postsplenectomy for total Ig 13.4± 19.3, for IgG 5.4± 1.8 , for IgM 1.9± 1.06, for IgA 2.1± 0.9 and the differences was statistically significant ( P<0.001). The Correlation studies between platelet count and PAIgs level in patients with chronic HCV infection presplenectomy revealed that there is significant correlation between platelets counts and total Ig (r -0.804 P= 0.000, r -0.907 P= 0.000, r - 0.467 , P = 0.002, r - 0.519, P 0.000).
Conclusion: Platelets associated antibodies might plays an important additive role in the aetiology of HCV associated thrombocytopenia and spleen is a major source of these antibodies. |
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| ISSN: | 2035-3006 |