Pregabalin dependence: Experiences from liaison psychiatric settings in Kashmir, North India: A case series

Pregabalin, a gamma-aminobutyric acid (GABA) analog, is a new-generation antiepileptic that is approved for the treatment of neuropathic pain, fibromyalgia, partial seizures, and generalized anxiety disorder. There is a rising concern regarding its abuse potential, and a handful of case reports have...

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Main Authors: Aaliya Khanam, Rajnish Raj, Zaid A. Wani, Yasir H. Rather, Iqra Arshad
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-01-01
Series:Industrial Psychiatry Journal
Subjects:
Online Access:https://journals.lww.com/10.4103/ipj.ipj_474_24
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author Aaliya Khanam
Rajnish Raj
Zaid A. Wani
Yasir H. Rather
Iqra Arshad
author_facet Aaliya Khanam
Rajnish Raj
Zaid A. Wani
Yasir H. Rather
Iqra Arshad
author_sort Aaliya Khanam
collection DOAJ
description Pregabalin, a gamma-aminobutyric acid (GABA) analog, is a new-generation antiepileptic that is approved for the treatment of neuropathic pain, fibromyalgia, partial seizures, and generalized anxiety disorder. There is a rising concern regarding its abuse potential, and a handful of case reports have highlighted the same. We present a case series on pregabalin dependence. In contrast to previous case reports, which focused on patients with a history of illicit drug abuse, we present cases of drug-naïve individuals for whom pregabalin was the first substance of abuse. The highlight of the study is that we describe cases of pregabalin intoxication and a rare case of pregabalin withdrawal, which presented as a lethal suicidal attempt to liaison psychiatric settings.
format Article
id doaj-art-c751e8ffe2f44b62a9691f8fcb3e9bca
institution OA Journals
issn 0972-6748
0976-2795
language English
publishDate 2025-01-01
publisher Wolters Kluwer Medknow Publications
record_format Article
series Industrial Psychiatry Journal
spelling doaj-art-c751e8ffe2f44b62a9691f8fcb3e9bca2025-08-20T02:11:20ZengWolters Kluwer Medknow PublicationsIndustrial Psychiatry Journal0972-67480976-27952025-01-0134111411610.4103/ipj.ipj_474_24Pregabalin dependence: Experiences from liaison psychiatric settings in Kashmir, North India: A case seriesAaliya KhanamRajnish RajZaid A. WaniYasir H. RatherIqra ArshadPregabalin, a gamma-aminobutyric acid (GABA) analog, is a new-generation antiepileptic that is approved for the treatment of neuropathic pain, fibromyalgia, partial seizures, and generalized anxiety disorder. There is a rising concern regarding its abuse potential, and a handful of case reports have highlighted the same. We present a case series on pregabalin dependence. In contrast to previous case reports, which focused on patients with a history of illicit drug abuse, we present cases of drug-naïve individuals for whom pregabalin was the first substance of abuse. The highlight of the study is that we describe cases of pregabalin intoxication and a rare case of pregabalin withdrawal, which presented as a lethal suicidal attempt to liaison psychiatric settings.https://journals.lww.com/10.4103/ipj.ipj_474_24intoxicationpregabalinpregabalin dependencesuicidewithdrawal
spellingShingle Aaliya Khanam
Rajnish Raj
Zaid A. Wani
Yasir H. Rather
Iqra Arshad
Pregabalin dependence: Experiences from liaison psychiatric settings in Kashmir, North India: A case series
Industrial Psychiatry Journal
intoxication
pregabalin
pregabalin dependence
suicide
withdrawal
title Pregabalin dependence: Experiences from liaison psychiatric settings in Kashmir, North India: A case series
title_full Pregabalin dependence: Experiences from liaison psychiatric settings in Kashmir, North India: A case series
title_fullStr Pregabalin dependence: Experiences from liaison psychiatric settings in Kashmir, North India: A case series
title_full_unstemmed Pregabalin dependence: Experiences from liaison psychiatric settings in Kashmir, North India: A case series
title_short Pregabalin dependence: Experiences from liaison psychiatric settings in Kashmir, North India: A case series
title_sort pregabalin dependence experiences from liaison psychiatric settings in kashmir north india a case series
topic intoxication
pregabalin
pregabalin dependence
suicide
withdrawal
url https://journals.lww.com/10.4103/ipj.ipj_474_24
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AT yasirhrather pregabalindependenceexperiencesfromliaisonpsychiatricsettingsinkashmirnorthindiaacaseseries
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