Decoding per- and polyfluoroalkyl substances (PFAS) in hepatocellular carcinoma: a multi-omics and computational toxicology approach

Decoding per- and polyfluoroalkyl substances (PFAS) in hepatocellular carcinoma: a multi-omics and computational toxicology approach

Abstract Background Per- and polyfluoroalkyl substances (PFAS), particularly perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), are synthetic chemicals known for their widespread use and environmental persistence. These compounds have been increasingly linked to hepatotoxicity and t...

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Bibliographic Details
Main Authors: Yanggang Hong, Deqi Wang, Zeyu Liu, Yuxin Chen, Yi Wang, Jiajun Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
PFAS
Network toxicology
Hepatocellular carcinoma
Machine learning
Single-cell sequencing
Molecular docking
Online Access:https://doi.org/10.1186/s12967-025-06517-z
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