Clinical aspects of acute mesenteric ischaemia
Acute mesenteric ischaemia (AMI) is a serious disease with mortality between 50 and 80 %. Oxidative stress plays a major role in the pathophysiology of AMI. AMI should be considered for any acute abdominal pain that requires analgesia with morphine and for which no other obvious aetiology is found....
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| Format: | Article |
| Language: | English |
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Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
2024-01-01
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| Series: | Scripta Medica |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2024/2490-33292405617M.pdf |
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| author | Matković Zoran Maličević Uglješa Gajić-Bojić Milica Krivokuća Aleksandra Đukanović Đorđe Đekić-Matković Nataša Aleksić Zoran |
| author_facet | Matković Zoran Maličević Uglješa Gajić-Bojić Milica Krivokuća Aleksandra Đukanović Đorđe Đekić-Matković Nataša Aleksić Zoran |
| author_sort | Matković Zoran |
| collection | DOAJ |
| description | Acute mesenteric ischaemia (AMI) is a serious disease with mortality between 50 and 80 %. Oxidative stress plays a major role in the pathophysiology of AMI. AMI should be considered for any acute abdominal pain that requires analgesia with morphine and for which no other obvious aetiology is found. CT is the main diagnostic procedure to confirm the diagnosis of AMI. There is no specific diagnostic biomarker for AMI that can be used in routine practice. AMI is an urgent diagnostic and therapeutic situation. Treatment of AMI includes a protocol combining digestive rest, curative anticoagulant, antiplatelet, antibiotic therapy, arterial revascularisation to salvage viable bowel and resection of necrotic digestive segments. The strategy of revascularisation depends on the mechanism of arterial occlusion, the morphological appearance of the lesions and the indications for exploratory laparotomy. Endovascular and open surgical techniques can be combined and complemented. Open surgical revascularisation is indicated in case of failure or impossibility of endovascular revascularisation and in case of need for laparotomy. Early diagnosis and timely surgical intervention are the cornerstones of modern treatment to reduce the high mortality of AMI. The emergence of endovascular approaches and modern imaging techniques is developing and providing new treatment options. A multidisciplinary approach based on early diagnosis and treatment is necessary. |
| format | Article |
| id | doaj-art-c74ca97f0f44460b99e699c0a8d5ac79 |
| institution | OA Journals |
| issn | 2490-3329 2303-7954 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine |
| record_format | Article |
| series | Scripta Medica |
| spelling | doaj-art-c74ca97f0f44460b99e699c0a8d5ac792025-08-20T02:18:25ZengMedical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of MedicineScripta Medica2490-33292303-79542024-01-0155562363510.5937/scriptamed55-505142490-33292405617MClinical aspects of acute mesenteric ischaemiaMatković Zoran0https://orcid.org/0000-0002-5216-5793Maličević Uglješa1https://orcid.org/0009-0004-7649-186XGajić-Bojić Milica2https://orcid.org/0009-0006-8433-7808Krivokuća Aleksandra3https://orcid.org/0009-0004-9431-3848Đukanović Đorđe4https://orcid.org/0000-0002-9887-9695Đekić-Matković Nataša5https://orcid.org/0009-0005-9731-6320Aleksić Zoran6https://orcid.org/0009-0002-7047-3500General Hospital Doboj, Doboj, The Republic of Srpska, Bosnia and HerzegovinaUniversity of Banja Luka, Faculty of Medicine, Centre for Biomedical Research, Banja Luka, The Republic of Srpska, Bosnia and HerzegovinaUniversity of Banja Luka, Faculty of Medicine, Centre for Biomedical Research, Banja Luka, The Republic of Srpska, Bosnia and HerzegovinaUniversity of Banja Luka, Faculty of Medicine, Centre for Biomedical Research, Banja Luka, The Republic of Srpska, Bosnia and HerzegovinaUniversity of Banja Luka, Faculty of Medicine, Centre for Biomedical Research, Banja Luka, The Republic of Srpska, Bosnia and HerzegovinaGeneral Hospital Doboj, Doboj, The Republic of Srpska, Bosnia and HerzegovinaUniversity Clinical Centre of the Republic of Srpska, Banja Luka, The Republic of Srpska, Bosnia and HerzegovinaAcute mesenteric ischaemia (AMI) is a serious disease with mortality between 50 and 80 %. Oxidative stress plays a major role in the pathophysiology of AMI. AMI should be considered for any acute abdominal pain that requires analgesia with morphine and for which no other obvious aetiology is found. CT is the main diagnostic procedure to confirm the diagnosis of AMI. There is no specific diagnostic biomarker for AMI that can be used in routine practice. AMI is an urgent diagnostic and therapeutic situation. Treatment of AMI includes a protocol combining digestive rest, curative anticoagulant, antiplatelet, antibiotic therapy, arterial revascularisation to salvage viable bowel and resection of necrotic digestive segments. The strategy of revascularisation depends on the mechanism of arterial occlusion, the morphological appearance of the lesions and the indications for exploratory laparotomy. Endovascular and open surgical techniques can be combined and complemented. Open surgical revascularisation is indicated in case of failure or impossibility of endovascular revascularisation and in case of need for laparotomy. Early diagnosis and timely surgical intervention are the cornerstones of modern treatment to reduce the high mortality of AMI. The emergence of endovascular approaches and modern imaging techniques is developing and providing new treatment options. A multidisciplinary approach based on early diagnosis and treatment is necessary.https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2024/2490-33292405617M.pdfmesenteric ishaemia, acuteoxidative stressmesenteric vascular occlusiondiagnostic imagingcttreatment |
| spellingShingle | Matković Zoran Maličević Uglješa Gajić-Bojić Milica Krivokuća Aleksandra Đukanović Đorđe Đekić-Matković Nataša Aleksić Zoran Clinical aspects of acute mesenteric ischaemia Scripta Medica mesenteric ishaemia, acute oxidative stress mesenteric vascular occlusion diagnostic imaging ct treatment |
| title | Clinical aspects of acute mesenteric ischaemia |
| title_full | Clinical aspects of acute mesenteric ischaemia |
| title_fullStr | Clinical aspects of acute mesenteric ischaemia |
| title_full_unstemmed | Clinical aspects of acute mesenteric ischaemia |
| title_short | Clinical aspects of acute mesenteric ischaemia |
| title_sort | clinical aspects of acute mesenteric ischaemia |
| topic | mesenteric ishaemia, acute oxidative stress mesenteric vascular occlusion diagnostic imaging ct treatment |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2024/2490-33292405617M.pdf |
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