Luteolin attenuates inflammation and apoptosis in LPS-induced ALI mice by activating the HGF/c-Met pathway

Luteolin attenuates inflammation and apoptosis in LPS-induced ALI mice by activating the HGF/c-Met pathway

ObjectiveTo investigate the protective effects of luteolin on ALI induced by lipopolysaccharide (LPS) in male mice and to explore the underlying mechanisms.MethodsA two-sample Mendelian randomization (MR) analysis was conducted to assess the causal relationship between hepatocyte growth factor (HGF)...

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Bibliographic Details
Main Authors: Jihong Bi, Yan Li, Lin Lu, Tingting Yin, Shaohua Mao, Run Zhang, Juan He, Xing Ni, Kai Wang, Jirui Bi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
luteolin
hepatocyte growth factor
acute lung injury
acute respiratory distress syndrome
inflammation
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1641486/full
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