Nature’s carriers: leveraging extracellular vesicles for targeted drug delivery
With the rapid development of drug delivery systems, extracellular vesicles (EVs) have emerged as promising stars for improving targeting abilities and realizing effective delivery. Numerous studies have shown when compared to conventional strategies in targeted drug delivery (TDD), EVs-based strate...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10717544.2024.2361165 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850138905619202048 |
|---|---|
| author | Qi Chen Yuyi Zheng Xuhong Jiang Yi Wang Zhong Chen Di Wu |
| author_facet | Qi Chen Yuyi Zheng Xuhong Jiang Yi Wang Zhong Chen Di Wu |
| author_sort | Qi Chen |
| collection | DOAJ |
| description | With the rapid development of drug delivery systems, extracellular vesicles (EVs) have emerged as promising stars for improving targeting abilities and realizing effective delivery. Numerous studies have shown when compared to conventional strategies in targeted drug delivery (TDD), EVs-based strategies have several distinguished advantages besides targeting, such as participating in cell-to-cell communications and immune response, showing high biocompatibility and stability, penetrating through biological barriers, etc. In this review, we mainly focus on the mass production of EVs including the challenges and strategies for scaling up EVs production in a cost-effective and reproducible manner, the loading and active targeting methods, and examples of EVs as vehicles for TDD in consideration of potential safety and regulatory issues associated. We also conclude and discuss the rigor and reproducibility of EVs production, the current research status of the application of EVs-based strategies to targeted drug delivery, clinical conversion prospects, and existing chances and challenges. |
| format | Article |
| id | doaj-art-c74728d1acb046fda1665bd94e77ff4e |
| institution | OA Journals |
| issn | 1071-7544 1521-0464 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj-art-c74728d1acb046fda1665bd94e77ff4e2025-08-20T02:30:28ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642024-12-0131110.1080/10717544.2024.2361165Nature’s carriers: leveraging extracellular vesicles for targeted drug deliveryQi Chen0Yuyi Zheng1Xuhong Jiang2Yi Wang3Zhong Chen4Di Wu5Interdisciplinary Institute for Medical Engineering, Fuzhou University, Fuzhou, P. R. ChinaKey Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, ChinaEpilepsy Center, Department of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, PR ChinaKey Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, ChinaWith the rapid development of drug delivery systems, extracellular vesicles (EVs) have emerged as promising stars for improving targeting abilities and realizing effective delivery. Numerous studies have shown when compared to conventional strategies in targeted drug delivery (TDD), EVs-based strategies have several distinguished advantages besides targeting, such as participating in cell-to-cell communications and immune response, showing high biocompatibility and stability, penetrating through biological barriers, etc. In this review, we mainly focus on the mass production of EVs including the challenges and strategies for scaling up EVs production in a cost-effective and reproducible manner, the loading and active targeting methods, and examples of EVs as vehicles for TDD in consideration of potential safety and regulatory issues associated. We also conclude and discuss the rigor and reproducibility of EVs production, the current research status of the application of EVs-based strategies to targeted drug delivery, clinical conversion prospects, and existing chances and challenges.https://www.tandfonline.com/doi/10.1080/10717544.2024.2361165Extracellular vesiclesdrug delivery systemnanoparticlecarrier |
| spellingShingle | Qi Chen Yuyi Zheng Xuhong Jiang Yi Wang Zhong Chen Di Wu Nature’s carriers: leveraging extracellular vesicles for targeted drug delivery Drug Delivery Extracellular vesicles drug delivery system nanoparticle carrier |
| title | Nature’s carriers: leveraging extracellular vesicles for targeted drug delivery |
| title_full | Nature’s carriers: leveraging extracellular vesicles for targeted drug delivery |
| title_fullStr | Nature’s carriers: leveraging extracellular vesicles for targeted drug delivery |
| title_full_unstemmed | Nature’s carriers: leveraging extracellular vesicles for targeted drug delivery |
| title_short | Nature’s carriers: leveraging extracellular vesicles for targeted drug delivery |
| title_sort | nature s carriers leveraging extracellular vesicles for targeted drug delivery |
| topic | Extracellular vesicles drug delivery system nanoparticle carrier |
| url | https://www.tandfonline.com/doi/10.1080/10717544.2024.2361165 |
| work_keys_str_mv | AT qichen naturescarriersleveragingextracellularvesiclesfortargeteddrugdelivery AT yuyizheng naturescarriersleveragingextracellularvesiclesfortargeteddrugdelivery AT xuhongjiang naturescarriersleveragingextracellularvesiclesfortargeteddrugdelivery AT yiwang naturescarriersleveragingextracellularvesiclesfortargeteddrugdelivery AT zhongchen naturescarriersleveragingextracellularvesiclesfortargeteddrugdelivery AT diwu naturescarriersleveragingextracellularvesiclesfortargeteddrugdelivery |